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International Journal ofAyurvedic and Herbal Medicine

Antidiabetic Potential Of Momordica Balsamina L. Fruit Pulp And Its Extracts In Streptozotocin Induced Diabetic Wistar Rats

Published:01 Sept 2012
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Faujdar S.1*, Gauttam V.2, Kalia A.N.3

1 M. Pharm., Department of Pharmacognosy, I.S.F. College of Pharmacy, Moga - 142001, Punjab

2 M. Pharm., (PhD.,)Department of Pharmacognosy, I.S.F. College of Pharmacy, Moga - 142001, Punjab

3 M. Pharm., PhD., Director Herbal Drug Research, Head of Department,Department of Pharmacognosy, I.S.F. College of Pharmacy, Moga - 142001, Punjab

Corresponding Author:Faujdar S.

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subjectAbstract

Momordica balsamina L. fruit pulp and its extracts were evaluated for antidiabetic potential. The study was carried out on whole fruit pulp powder (FPP), aqueous methanolic extract 90% (AME) and aqueous extract for 3 weeks on streptozotocin (STZ) induced diabetic Wistar rats. The biochemical parameters studied were serum glucose level, lipid profile and liver glycogen content along with this body weight was also measured. The ME showed significant (P<0.05) serum glucose lowering effect, improvement in the complete lipid profile and check on the loss of body weight in comparison to control diabetic rats. The results were comparable with glibenclamide (GLB) 500 µg/kg, standard antidiabetic drug. Phytochemical screening of the AME revealed the presence of alkaloids, flavonoids and steroids. Our findings suggest, the FPP and AME have significant (P<0.05) antidiabetic potential and can act as an effective oral hypoglycemic drug in diabetes.

sellKeywords

CucurbitaceaeDiabetesMomordicinStreptozotocinGlibenclamide

format_list_numberedReferences

  1. Settin D Jr, Boxer GE. Studies in carbohydrate metabolism III. Metabolic defects in alloxan diabetes. J Biol Chem 1944;156:217.
  2. Brandy RO, Gurin S. Biosynthesis of labelled fatty acids and cholesterol in experimerimental diabetes. J Biol Chem 1950;187:589.
  3. Randle PJ, Garland PB, Hales CN, Newsholme EA. The glucose fatty acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes. The Lancet 2006;1:785.
  4. Taskinen MR. Lipoproteins and apoproteins in diabetes. In: Belfiore F., Bergman, R.N., Molinatti, G.M (Eds.). Current Topics in Diabetes Research 1993;12:122-134.
  5. Huse DM, Oster G, Killen AR, Lacey MJ, Goldtitz GA. The economic costs of noninsulin dependent diabetes mellitus. JAMA 1988;262:2708-2713.
  6. Bayne JW. Role of oxidative stress in development of complications in diabetes. Diabetes 1991;40:405-412.
  7. Chattopadhyay RR, Medd CS, Das S, Basu TK, Podder G. Hypoglycaemic and anti-hyperglycaemic effect of Gymnema sylvestre leaf extract in rats. Fitoterapia 1993;64:450-454.
  8. Ponnachan TC, Panikkhar KK. Effect of leaf extract of Aegle marmelos in diabetic rats. Indian J Exp Biol 1993;31:345-347.
  9. Subramonium A, Pushangadan P, Rajasekaran S. Effects of Artemisia pallens wall on blood glucose levels in normal and alloxan induced diabetic rats. J Ethnopharmacol 1996;50:13–17.
  10. Li WL, Zheng HC, Bukuru J, De Kimpe N. Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. J Ethnopharmacol 2004;92:1–21.
  11. Kalia AN, Saini Sushila, Yadav JP. Hypoglycaemic activity of S. persica and S. oleoides in Diabetic albino rats. J Med Aromat Plant Sci 2006;28: 1-14.
  12. Atta-ur-Rahman, Zaman K. Medicinal plants with hypoglycemic activity. J Ethnopharmacol 1989;20:553-564.
  13. Otimenyin O Sunday, Uguru MO, Ogbonna A. Antimicrobial and hypoglycemic effects of Momordica balsamina. Linn. J Nat Prod 2008;1:03-09.
  14. Otimenyin O Sunday, Uguru MO, Akanbi BE. Anti-diarrhoeal effect of aqueous extracts of Momordica balsamina and Stachytarpheta indica in rats. J Nat Prod 2008;1:36-45.
  15. Bot YS and Mgbojinke LO. Screening of the fruit pulp extract of Momordica balsamina for its anti-HIV property. African Journal of Biotechnology 2007;6:47-52.
  16. Olabode HO, Eghafona NO, Mgbojikwe LO. The role of Momordica balsamina fruit pulp extract in development of immunity to avian Newcastle disease virus. Nigerian Veterinary Journal 2007;1:41-47.
  17. Harborne J B. Phytochemical methods. 3rd Ed. Chapman and Hall publishers. London1998.
  18. Kumar A, Ilavasaran Rc, Jayachandran T, Deccaraman M, Anvindin P, Padmanabhan N, Krishan MRV. Anti-diabetic activity of Syzygium cumini and its isolated compound against streptozotocin-induced diabetic rats. J Med Plant Res 2008;2:246-249.
  19. Yassin MM, Ashour AR, Elyazji NR. Alterations in body weight, protein profile, nonprotein nitrogen constituents and kidney structure in diabetic rats under glibenclamide treatment. Journal of the Islamic University of Gaza 2004;12:37-54.
  20. Rajasekaran S, Ravi K, Sivagnanam K, Subramanian S. Beneficial effects of Aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes. Clin Exp Pharmacol Physiol 2006;33:232–237.
  21. Trinder P 1969. Determination of blood glucose using an oxidase-peroxidase system with a non carcinogenic chromogen. JCP 1969;22:158-161.
  22. Baron AD. Postprandial hyperglycaemia and a-glucosidase inhibitors. Diabetes Research and Clinical Practice 1998;40:51-55.
  23. Roeschlau P, Bernt E, Gruber WJ. Estimation of serum cholesterol by cholesterol oxidase and peroxidase method. J Clin Chem and Biochem 1974; 12:40-43.
  24. Warnick GR, Nguyen T, Albers A. A comparison of improved precipitation methods for quantification of high density lipoprotein cholesterol. Clin Chem 1985;26:1775.
  25. Rifai N, Bachorik PS, Albers JJ. Lipids, lipoproteins and apolipoproteins. In: C.A. Burtis, E.R., Ashwood, Tietz Textbook of Clinical Chemistry.Philadelphia: W.B.Saunders Company 1999, 809-861.
  26. Kemp A, Kits van Heijiningen AJM. Free and Fixed glycogen in rat muscle. Biochem J 1955;59:487-491.
  27. Vijayalakshmi MA, Noor A, Gunasekaran S, Soosai Manickam A. Antidiabetic activity of Aloe vera and histology of organs in streptozotocin induced diabetic rats. Current Science 2008;94:1070-1076.
  28. Sharma SR, Dwivedi SK, Swarup D. Hypoglycaemic, antihyperglycemic and hypolipidemic activities of Caesalpinia bonducella seeds in rats. J Ethnopharmacol 1997;58:39-44.
  29. Brunton LL, Lazo JS, Parker KL. Goodman & Gilman's the pharmacological basis of therapeutics. McGraw Hill, USA 2006:1613-1645.
  30. Chakravarthy BK, Gupta S, Gambhir SS, Gode KD. Pancreatic ẞ-cell regeneration in rats by (-)-epicatechin. Lancet 1981; 2:759-760.
  31. Robinson CH, Lawer MR, Chenoweth WL, Lawick AE. Diabetes mellitus: Normal and therapeutic nutrition. MacMillan Publishing Co. New York: USA 1986: 504-519.
  32. Manicham M, Ramanathan M, Jahromi MA, Chansouria JP, Ray AB. Antihyperglycemic activity of phenolics from Pterocarpus marsupium. J Nat Prod 1997;60:609-610.
  33. Gross B, Stale B. PPAR agonists: Multimodel drugs for the treatment of type 2 diabetes. Best Practice and Research Clinical Endocrinology and Metabolism 2007;21:687-71.
  34. Fruchart JC. Novel peroxisome proliferator activated receptor a-agonists. Am J Cardiol 2007;100:41-46.
  35. Kedar P, Chakrabarti CH. Effect of bittergourd (Momordica charantia) seed and glibenclamide in streptozotocin induced diabetes mellitus. Ind J Exp Biol 1982;20:232-235.
  36. Sharma SB, Nasir A, Prabhu KM, Murthy PS, Dev G. Hypoglycemic and hypolipidemic effect of ethanolic extract of seeds of Eugenia jambolana in alloxan-induced diabetic rabbits. J Ethnopharmacol 2003;85:201-206.
  37. Chi MS. Effects of garlic products on lipid metabolism in cholesterol fed rats. Proc Soc Exp Biol Med 1982;171:174-178.
  38. Anandharjan R, Vishwakarma RA, Balakrishnan A, Pathmanathan K, Shankernarayana NP. Upregulation of GLU-4 and PPARy by an isoflavone from Pterocarpus marsupium on L6 myotubes: A possible mechanism of action. J Ethnopharmacol 2005;97:253-260.
  39. Kersten S, Mandard S, Stienstra R, Escher P, Tan NS, Kim I. Glycogen synthase 2 is a novel target gene of peroxisomes proliferator activated receptors. Cell Mollife Sci 2007;64:1145-1157.
  40. Rang HP, Dale MM, Ritter JM. Text book of Pharmacology. Churchill Livingstone, Edinburgh, London. 1999.
  41. Hotta N, Koh N, Sakakibara F, Nakaruma J, Hamada Y, Hara T. Effect of beraprost sodium and insulin on the electroretinogram, nerve conduction and blood flow in rats with streptozotocin induced diabetes. Diabetes 1996;45:361-366.
  42. Badr- Eldin NK, Ismael NR, Shoman SA, EL-Merzebani MM. Pre and post treatment with Panax ginseng extract on streptozotocin induced diabetes in male rats. J Egypt Ger Soc Zool 1998;25:145-167.
  43. Fernstrom MH, Fernstrom JD. Large changes in serum free tryptophan levels do not alter tryptophan levels. Studies in streptozotocin, diabetic rats. Life Sci 1993;52:907-916.
  44. Farouque HMO, Meredith LT. Effects of inhibition of ATP sensitive potassium channels on metabolic vasodilation in the human forearm. Clin Sci 2003;104:39-46.

How to Cite

S., F., V., G., & A.N., K. (2012). Antidiabetic Potential Of Momordica Balsamina L. Fruit Pulp And Its Extracts In Streptozotocin Induced Diabetic Wistar Rats. International Journal of Ayurvedic and Herbal Medicine, 2(5). https://doi.org/10.47191/ijahm/v2i5.01

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