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International Journal ofAyurvedic and Herbal Medicine

Hypoglycaemic Activity Of Cedrela Toona Roxb. Leaves In Alloxan – Induced Diabetic Rats.

Published:23 Sept 2012
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Shah Kinjal H1*, Dr. Patel Piyush M2

1 Research Scholar, Singhania University, Pacheri Bari, Jhunjunu, Rajasthan, India

2 Professor, Shri B. M. Shah College Of Pharmaceutical Education And Research, Modasa, Gujarat, India

Corresponding Author:Shah Kinjal H

picture_as_pdfDownload link10.47191/ijahm/v2i5.06

subjectAbstract

Leaf extracts of Cedrela toona Roxb. were evaluated for their antidiabetic activity in Alloxan induced diabetic rats. Diabetes was induced in experimental rats by a single intraperitoneal injection of alloxan monohydrate (150 mg/kg body wt). Ethanol, Chloroform, and Aqueous extracts of Cedrela toona fruits were administered orally at a dose of 250 mg/kg body wt to diabetic rats. Blood glucose was analysed using glucose oxidase - peroxidase reactive strips. Significant antidiabetic activity was observed in ethanolic extract in terms of reduction of fasting blood glucose level in diabetic rats. After 7 hour blood glucose was depressed by 8.2% (P < 0.05) and 10.06% (P < 0.01) in alloxan - induced diabetic rats. The effect of ethanolic extract particularly at 250 mg/kg was comparable to that of standard drug Glibenclamide (1 mg/kg body wt.)

sellKeywords

AlloxanCedrela toonaDiabetesLeafGlibenclamideHypoglycaemic

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  1. Khare, C.P. Indian Medicinal Plant. An Illustrated Dictionary. Published by Springer, 2006,112 - 113.
  2. Loupee D, Oteng- Amoaka A.A, Brink M. Timber 1. Voll, vol7, PROTA publishers,2008,557-559.
  3. http://en.wikipedia.org/wiki/Toon
  4. Kashyapa K, Chand R. The useful plants of India. National Institute of Sciences Communication and Information Resources, New Delhi,2006,112-113.
  5. Nadkarni A K. Indian Materia Medica. Edn 3, Vol I, Popular prakashan, 2009, 1908.
  6. Pullaiah, T. Biodiversity in India. Vol4, Published by Regency Publication ,2006,160.
  7. Warrier P.K, Nambiar V P K. Indian Medicinal Plant: a compendium of 500 species. Vol 5, Orient Langman Priceate, 1996, 294.
  8. Kiritikar K.R, Basu B.D, Indian Medicinal Plants. International Book distributors, Dehradhun 248 001,1995,562.
  9. Hodges R, McGeachin, S.G, Raphael R.A. The chemistry of cedrelone. J Chem Soc 1963;p.2515-2526.
  10. Karus W, Bauman S, Bokel M, Cramer R, Grimminger W, Handlmeir R, Keil E, Keller A, Klingele M, Pohnl H, Schwinger M. In: Proceeding of the 1st Princess Chulabhorn Sciences Congress, 1st Congress on Natural Products Bangkok Vol2, 1987,554.
  11. Gopalakrishnan G, Singh N D P, Kasinath V, Rajan S S, Malathi R. Photooxidation of cedrelone, a tetratriterpenoids from Toona ciliata. Photochem Photobio 2000;72(4):464-466.
  12. Chowdhary R, Rashid R B, Sohrab M H, Hasan C M. 12alpha – hydroxystigmast-4-en-3-one: a new bioactive steroid from Toona ciliate (Meliaceae). Pharmazie 2003;58:272-273.
  13. Chaudhary R. 5- Methylcoumarins from Toona ciliata stem bark and their chemotaxonomic significance. Biochem Sys Eco 2004;32:103-105.
  14. Lio S-G, Yang S-P, Yuan T, Zhang C-R, Chen H-D, Wu Y, Xu Y-K and Yue J-M. Limonoids from the Leaves and Stems of Toona ciliata. J Nat Prod 2007;70:1268-1273.
  15. Veiga TA, Gonzalez-Vazquez R, Neto JO, Silva MF, King-Diaz B, Lotina-Hennsen B. Siderin from Toona ciliata (Meliaceae) as photosystem II inhibitor on spinach thylakoids. Arch Biochem Biophys 2007;465(1):38-43.
  16. Karus W, Grimminger W. Toonafolin, a novel tetranortriterpenoids B- lactone from Toona ciliata M.J.Roem. Var. australis (Meliaceae). Ann. Chem. 1981;1838-1843.
  17. Ning J, Di Y-T, Li S-F, Geng Z-L, HeH-P, Wang Y-H, Wang Y-Y, Li Y, Li S-L, Hao X-L. Polyynes from Toona ciliate var. ciliata and related Cytotoxicity Activity. Helv Chim Acta 2011;94:376-381.
  18. Li J Z, Mo H N, Ning X M. Study on chemical constituents of tree of Toona ciliata. Zhong Yao Cai 2009;32(10):1539-1542.
  19. Gambo-Castro I, Das M F, Silva D, Fo E R, Fernades J B, Vieira PC, Pinheiro A L. Unusual natural 9,10-dihydrophenthrenes from roots of Toona ciliata. ARKIVOC 2004;4:45-53.
  20. Ning J, He H-P, Li S-F, Geng Z-L, Fang X, Di Y-I, Li S –L, Hao X-J. Triterpenoids from leaves of Toona ciliata. J Asian Nat Prod Res 2010;12(6):448-452.
  21. Seifried HE, Anderson DE, Fisher EI, Milner JA. A review of the interaction among dietary antioxidants and reactive oxygen species. J Nutr Biochem 2007;18:567-79.
  22. Diplock AT, Charleux JL, Crozier- Willi G, Kok FJ, Rice-Evans C, Roberfroid M, et al. Functional food science and defense against reactive oxidative species. Br J Nutr 1998;80:S77- 112.
  23. Maxwell S. Antioxidant therapy: Does it have a role in the treatment of human disease? Expert opin Investig Drug 1997; 6(2):11-36.
  24. Malairajan P, Gopalakrishnan G, Narasimhan S, Veni K JK, Kavimani S. Anti- ulcer activity of crude alcoholic extract of Toona ciliata Roemer (heart wood). J Ethanopharmacol 2007;110:348-351.
  25. Malairajan P, Gopalakrishnan G, Narasimhan S, Veni K J K. Analgesic activity of some Indian medicinal plants. J Ethanopharmacol2006;106:425-428.
  26. Govindachari T R, Suresh G, Gopalakrishnan G, Masilamani S, Banumathi B. Antifungal activity of some tetratriterpenoids. Fitoterpia 2000;71:317-320.
  27. Chowdhary R, Hasan C M, Rashid M A. Antimicrobial activity of Toona Ciliata and Amoora rohituka. Fitoterpia 2003;74:155-158.
  28. Bibi Y, Nisa N, Chaudhary FM, Zia M. Antibacterial activity of some selected medicinal plants of Pakistan. BMC Complementary and Alternative Medicine 2011, 11:52.
  29. Chowdhary R, Hasan C M, Rashid M A. Bioactivity from Toona ciliata Stem Bark. Pharmaceutical Bio 2003;41(4):281-283.
  30. Harbone JB, Phytochemical Methods: A guide to modern techniques of plant analysis, 3rd Edition, Chapman and Hall, London, 1998
  31. PHS (Public Health Service) Policy on Human Care and Use of laboratory animals, available from office for protection from research risks, Washington DC, U S Department of health Survice(Bethesda, NIII),1986.
  32. Kastumata KY, Kastumama TO and Kastumama K, potentiating effect of combined usage of three sulfonylurea drugs on the occurrence of alloxan diabetic rats, Hormone Metab Res,1999,25,125-126.
  33. Mandal SC, Mukharjee PK, Saha K,das J, Pal M and Saha BP, Hypoglycaemic effect of Ficus racemosa L. 9Moraceae) leaves in Streptozotocin induced diabetic rats, Nat Prod

How to Cite

H, S. K. & M, D. P. P. (2012). Hypoglycaemic Activity Of Cedrela Toona Roxb. Leaves In Alloxan – Induced Diabetic Rats.. International Journal of Ayurvedic and Herbal Medicine, 2(5). https://doi.org/10.47191/ijahm/v2i5.06

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