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International Journal ofAyurvedic and Herbal Medicine

The moisture content of NIPRISAN a polyherbal formulation for the management of sickle cell anaemia affects the direct compression tableting properties of silicified microcrystalline cellulose

Published:20 Sept 2012
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martins emeje1*, Frank Ohwoavworhua2, Christiana Isimi2, Olobayo Kunle2

1 National Institute for Pharmaceutical Research & Development, Abuja, Nigeria

2 Department of Pharmaceutical Technology and Raw Materials Development, National Institute for Pharmaceutical Research & Development, Abuja, Nigeria

Corresponding Author:martins emeje

picture_as_pdfDownload link10.47191/ijahm/v2i5.05

subjectAbstract

The aim of this study is to investigate the effect of the moisture content of NIPRISAN®, a herbal extract on the direct compression tableting properties of SMCC 50 and SMCC 90. NIPRISAN® extract was exposed to a saturated solution of potassium nitrate in a glass dessicator for one week. Granules were compressed at varying compression pressures and subjected to various tests. Results obtained show that, the SMCC 50-NIPRISAN® combinations had higher moisture content than SMCC 90-NIPRISAN® combination. At 18 - 25 KN compression pressure, tablet hardness decreased with addition of the herbal extract. There was no discernible difference in the effect of moisture on tablet hardness irrespective of whether SMCC 50 or 90 was used as the direct compression agent. Initial addition of the extract to SMCC had the most pronounced effect on tablet strength. At moisture level greater than 18.4 %, no suitable tablets could be produced. With tablets compressed at 26.25 KN, the initial addition of the extract did not have any appreciable effect on the hardness of the tablet, with both grades of SMCC used. Increasing the moisture content to 26 % with_SMCC_50 resulted in tablets of unsuitable hardness. Deformation characteristics of SMCC 50 were more affected by moisture than SMCC 90. Generally, there was increased tablet hardness with increase in the compression pressure irrespective of the grade of SMCC used. Friability results show that as the moisture content of the tablets increased, the tablets become more friable. Results of tablet disintegration show that, the presence of the extract in the formulation increased the disintegration time irrespective of the SMCC used and this was most pronounced at the higher compression pressures of 25 and 26.25 KN. Disintegration times with SMCC 50 was longer than those of SMCC 90. Pressure variation and moisture content also affected disintegration times. At lower pressures and increased moisture contents, there was a decreased disintegration time irrespective of SMCC grade. SMCC 50 and 90 are suitable direct compression excipients and disintegrants in herbal solid dosage formulations, the optimal moisture level was found to be 28.7 %.

sellKeywords

polyherbal formulation

format_list_numberedReferences

  1. Bolhuis GK, Chowhan ZT, (1996). Materials for direct compaction. In: Alderborn G, Nysrom C (Eds). Pharmaceutical Powder compaction Technology. Marcel Dekker, pp 419-501.
  2. Khalaf AS, Tobyn MJ, Staniforth JN. (1997). Measurement of the flow properties of silicified microcrystalline cellulose. Proceedings of the AAPS conference. PT 2583.
  3. Shewood BE, Hunter EA, Staniforth JN, (1996). Silicified microcrystalline cellulose: A new class of high functionality tablet binders for direct compression tableting. Proceedings of the AAPS conference. PT 6164.
  4. Staniforth JN, Chatrath M. (1996). Towards a new class of high functionality tablet binders. I: Quasi hornification of microcrystalline cellulose and loss of functionality. Proceedings of the AAPS conference. PT 6206.
  5. Riba MD, Segado X, Ferrer F, (1997). Silicified microcrystalline cellulose: A comparative evaluation of this new high functionality direct compression excipient. Proceedings of the AAPS conference. PT 1038.
  6. Tobyn MJ, McCarthy GP, Staniforth JN, Edge S, (1998). Physicochemical compression between MCC and SMCC. Int. J. Pharm. 169, 183 – 194
  7. Gamaniel K, Amos S, Akah P, Samuel BB, Kapu S, Olusola A, Abayomi O, Okogun JI, and Wambebe CN. (1998). Pharmacological profile of NIPRD 94/002/1-0: A novel herbal antisickling agent. J. Pharm. Res. Dev. 3 (2) 89 – 94
  8. British Pharmacopoeia 1993
  9. Teng CD, Alkan MH, Groves NO. (1986). The effect of adsorbed water on compaction properties and the dissolution of quinine HCl from compacted waters of soy pollen. Drug Dev. Ind. Pharm. 12(11-13) 2325 – 2336
  10. Nystrom Glazer (1985). Studies on direct compression of tablets. XIII. The effect of some dry binders on the tablet strength of compounds with different fragmentation propensity. Int. J. Pharm. 23 (3), 255 – 63
  11. Bangudu AB, Pipel N, (1985). Effects of interacting variables on the tensile strengths and disintegration times of paracetamol tablets. J. Pharm. Pharmacol. 37 (12), 903 – 5
  12. Lamberson RL, Raynor GE, (1976). Tableting properties of microcrystalline cellulose. Manuf. Chem. Aerosol News, 47 (6), 55 – 61
  13. Armstrong N. Cham. (1986). Changes in the particle size distribution during compaction of two pharmaceutical powders with dissimilar consolidation mechanisms. Drug Dev. Ind. Pharm. 12 (11-13) 2043-59
  14. Phuoc NH, Ho NT, Bucmann M, Kesserlring UW. (1987). Experimentally optimized determination of the partial and total cohesion parameters of the partial and total cohesion parameters of an insoluble polymer (microcrystalline cellulose) by gas-solid chromatography. Int. J. Pharm. 34 (3), 217-23
  15. Karehill PG, Nystrom C. (1990). Studies on direct compression of tablets. XXII. Investigation of strength increase upon ageing and bonding mechanisms for some plastically deforming materials. Int. J. Pharm. 64 (1), 27 – 34
  16. Okhamafe AO, Igboechi AC, Ubrufih CE, Akinyemi BO, Ighalo MO. (1992). Celluloses extracted from groundnut shell and rice husk 2: disintegrant properties. Pharmacy World Journal 9 (1), 11 -16
  17. Wan LSC, Heng PWS. (1986). Action of surfactant on disintegration and dissolution of tablets containing MCC. Pharm. Acta Helv. 6 (5), 157 – 163

How to Cite

emeje, m., Ohwoavworhua, F., Isimi, C., & Kunle, O. (2012). The moisture content of NIPRISAN a polyherbal formulation for the management of sickle cell anaemia affects the direct compression tableting properties of silicified microcrystalline cellulose. International Journal of Ayurvedic and Herbal Medicine, 2(5). https://doi.org/10.47191/ijahm/v2i5.05

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