Formulation and Evaluation of Immediate Release Bilayer Tablets of Telmisartan and Hydrochlorothiazide
1 Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengode, Tamil Nadu state, India.
Corresponding Author:R.Natarajan
Current state of art is witnessing a revolution in new techniques for drug delivery. Nevertheless, convenience of manufacturing and patient compliance has maintained their significant importance in the design of drug delivery systems. The primary aim of this development was to have a stable formulation of Antihypertensive drugs of the Telmisartan and Hydrochlorothiazide immediate release Bilayer tablet, and to study the dissolution profile with the reference product. The Formulation development work was initiated with Wet granulation. Telmisartan is converted to its sodium salt by dissolving in aqueous solution of Sodium Hydroxide, in order to improve solubility and drug release. Lactose Monohydrate and Microcrystalline Cellulose are used as diluents. Starch paste is prepared in Purified Water and is used as the binder. Sodium Starch Glycolate is added as a disintegrating agent. Magnesium Stearate is used as the lubricant. The prepared granules are compressed into Double layer compression machine. The tablets thus formulated with higher proportion of sodium starch glycolate showed satisfactory physical parameters, and it was found to be stable and in-vitro release studies are shown that formulation (F-T5H5) was 101.11% and 99.89% respectively. And the formulation T5H5 is further selected and compared with the release profile of innovator product, it was found to be similar (f2 factor) to that of marketed product.
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- AR Mullaicharam, Ph. Maisa Shumo, P.Muthuprasanna., Susained Release Matrix Metoprolol Tartrate with Inlay Hydrochlorothiazide Tablet., International Journal of Pharma and Bio Sciences, 2010, 1(2), 1-10.
- Bhavesh Shiyani, Suresh Gattani, Sanjay Sharana., Formulation and Evaluation of Bilayer Tablet of Metoclopramide Hydrochloride and Ibuprofen., AAPS PharmaSci Tech, 2008, 9(3), 818-827.
- Nagaraju.R, Rajesh kaza., Formulation and Evaluation of Bilayer Sustained Release Tablets of Sulbutamol and Theophylline., International Journal of Pharmaceutical Science and Nanotechnology., 2009,2(3),638-946.\
- Peter. A.Heredith., Angiotensin II Receptor Antagonist alone and combined with Hydrochlorothiazide.,Potential Benefits Beyond the Anti-hypertensive effect,2005,5(3),171-183.
- S.Ashutoshkumar, A.Arunachalam, M.Karthikeyan, S.Mandipa, V. Ravishankar, R.Senthilaraj., Design and Evaluation of Sustained Release Tablet of Telmisartan., An International Journal of Pharmaceutical Sciences, (2010) 0976-7908,595-603.
- S.B. Wankhede, M.R.Tajne, K.R.Gupta, S.G. Wadodkar., RP-HPLC Method for Simultaneous Estimation Of Telmisartan and Hydrochlorothiazide in Tablet Dosage Form., Indian Journal of Pharmaceutical Sciences, 2007, 298-300.
- Sharma Shailesh, Singh Gurjeet, Gupta GD, Formulation Design and Optimization of Mouth Dissolving Tablets of Domperidone using Sublimation Technique., International Journal of Pharmaceutical sciences.,2010,1(1),128-136.
- Uday S Rangole, PS Kawtikwar, DM Sakarkar.,Formulation and In- Vitro Evaluation of Rapidly Disintegrating Tablets Using Hydrochlorothiazide as a Model Drug. Reseach J. Pharma and Tech,2008,1(4),349-352.
How to Cite
R.Natarajan, Patel, N., & N.N.Rajendran (2011). Formulation and Evaluation of Immediate Release Bilayer Tablets of Telmisartan and Hydrochlorothiazide. International Journal of Ayurvedic and Herbal Medicine, 1(2). https://doi.org/10.47191/ijahm/v1i2.01
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