Volume 1, Issue 2

The study was aimed to evaluate preliminary phytochemical screening and in vitro anti microbial activities of Grewia tiliaefolia. The literature review reveals its usage in folk medicine in the tr eatment of rheumatism, vitia ted conditions of pita and kapha, burning sensation, hyperdipsia, pharyngopathy, cough, skin diseases, pruritis, wounds, ulcers, diarrhoea, hematemesis, epistaxis, haemorrhages, seminal weakness and general debility¹. The literature review reveals that no scientific systematic evaluation has been done in alcoholic extract; so, an attempt has been made to study anti- microbial activity. The aerial parts of the selected medicinal plant was chosen for the study. Further preliminary phytochemical screening indicates the presence of flavones, steroids, glycosides, sugars, alkaloids, quinines, phenols, tannins, saponins in methanolic extract. The methanol leaf extracts of Grewia tiliaefolia., showed significant antibacterial activity against Bacillus subtilis, Escherichia coli, Pseudomonas Aurignosa, Escherichia Feacalis, Staphylococcus aureus, Salmonella Typhi A, Salmonella Typhi B, Vibrio cholera and Coagulase negative staphylococci . Signifiacant antifungal activity was seen against Aspergillus flavus, Aspergillus niger, candida albicans and Fusarium verticillioides. Grewia tiliaefolia exhibits good activity and percentage inhibition as comparable to the standard.

The aim of present study was to evaluate the anthelmintic activity of ethanolic and aqueous extracts of the whole plant of Sphaeranthus indicus Linn. against Pheretima posthuma and Ascardia galli Each extracts were studied in the bioassay at concentrations of 10, 50, 100 mg/ml, which involved determination of time of paralysis and time of death of the worms. Both extracts exhibited anthelmintic activity in a dose-dependent manner. The most significant activity was observed at the highest concentration of 100 mg/mL against both types of worms. Albendazole (10 mg/ml) and distilled water were included as standard reference and control, respectively. The present study indicates that the whole plant of Sphaeranthus indicus Linn. does possess anthelmintic activity.

The liver is the body's most important organ after the heart, performing many important functions including metabolism, detoxification and formation of important compounds including blood clotting factors. It also filters, regulates and stores blood. Stress, poor diet, and over-medication are common problems which may lead to stress and functional damage to the liver. As a result, it may affect memory, sleep, thyroid, body weight and other body functions. The human liver contains thousands of enzymes, which are special types of protein cells that help necessary chemical reactions to take place. Liver enzymes trigger activity in the body's cells, speeding up and facilitating naturally occurring biochemical reactions, and maintaining various metabolic processes within the liver. A wide range of health problems can lead to elevated liver enzymes. Some common causes include, Adrenal insufficiency (inadequate levels of hormones released by the adrenal gland), Alcohol abuse, Autoimmune disorders of the liver and bile ducts, such as autoimmune hepatitis, Celiac disease, Diabetes, Elevated triglycerides (fat tissues) and infections such as viral hepatitis and mononucleosis. Several conditions are linked with elevated liver enzyme levels, including hepatitis, cirrhosis, nonalcoholic fatty liver disease, adverse reactions to medication and obesity. Physicians can detect elevated liver enzyme levels through several liver function tests. Several causes and diseases can be at the root of elevated liver enzyme levels, so it is important to consult a physician to determine the best treatment plan. However, in some instances, elevated liver enzyme level can be lowered with natural treatments.

Current state of art is witnessing a revolution in new techniques for drug delivery. Nevertheless, convenience of manufacturing and patient compliance has maintained their significant importance in the design of drug delivery systems. The primary aim of this development was to have a stable formulation of Antihypertensive drugs of the Telmisartan and Hydrochlorothiazide immediate release Bilayer tablet, and to study the dissolution profile with the reference product. The Formulation development work was initiated with Wet granulation. Telmisartan is converted to its sodium salt by dissolving in aqueous solution of Sodium Hydroxide, in order to improve solubility and drug release. Lactose Monohydrate and Microcrystalline Cellulose are used as diluents. Starch paste is prepared in Purified Water and is used as the binder. Sodium Starch Glycolate is added as a disintegrating agent. Magnesium Stearate is used as the lubricant. The prepared granules are compressed into Double layer compression machine. The tablets thus formulated with higher proportion of sodium starch glycolate showed satisfactory physical parameters, and it was found to be stable and in-vitro release studies are shown that formulation (F-T5H5) was 101.11% and 99.89% respectively. And the formulation T5H5 is further selected and compared with the release profile of innovator product, it was found to be similar (f2 factor) to that of marketed product.

The purpose of this study was to develop stable oral nutraceutical tablets containing herbs with high nutritive value like Mushroom, Amalaki and Ashwagandha in whole powder form. Simple direct compression technique was used for formulation of immediate release tablets. Effect of various directly compressible diluents like microcrystalline cellulose, dicalcium phosphate anhydrous and mannitol was explored. Final selection of formulation was done based on evaluation of batches for various pre-compression and post-compression parameters. Herbal ingredients are susceptible to degradation in presence of moisture and hence moisture protective coating was given to optimized batch of tablets that would improve their stability and shelf life.