Phytopharmaceutical Development of A Polyherbal Spray for Topical Management of Joint Pain: A Formulation Based Study

Joint pain, which is frequently brought on by diseases like psoriatic arthritis, gout, and arthritis, has a major negative impact on both patient health and healthcare systems. The goal of this research is to create and assess a non-pressurized polyherbal spray that can be applied topically to effectively treat joint pain. Each of the four medicinal ingredients in the formulation-Nirgundi (Vitex negundo Linn.), Guggul (Commiphora wightii), Menthol (Mentha), and Bhimseni Camphor (Cinnamomum camphora)-has analgesic and anti-inflammatory qualities. Different amounts of ethanol, water, glycerin, and DMSO were used to create a range of spray formulations that served as co-solvents and permeation enhancers. A thorough physicochemical assessment of the optimized formulation was conducted, covering pH, viscosity, evaporation time, spray pattern, and average dose weight. The findings showed that the polyherbal spray was eco-friendly, stable, and easy to use. It also showed promise for treating localized pain and improving patient compliance. This study provides a promising substitute for the topical treatment of joint pain and encourages the integration of ancient herbal medicines with contemporary pharmaceutical delivery systems.