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Volume 15, Issue 4

July-August 2025

8 RESEARCH ARTICLES

Ashif Iqubal1, Sayed Abdur Rehman2, Senthil Kumar T3, Sumit Sharma4, Anu Mahajan5, Nausheen Khan6, Keshav Kumar7, Athar Ali8, Mohammad Kashif Iqubal9, Abdul Qadir*
1Research and Development Advisor, Herbified Healthcare, New Delhi-110020, India
2Research and Development Executive, Herbified Healthcare, New Delhi
3Directorate of Ayush, Ayurveda & Unani Tibbia college campus, Karol bagh, New Delhi-110005, India
4Director, Frontro Pharmaceuticals Pvt Ltd, Greater Noida, Faridabad
5Senior Research Fellow, PhD scholar, Symbiosis School of Culinary Arts and Nutritional Science (SSCANS), Pune
6Director Herbified Healthcare, New Delhi-110020, India
7Research Scholar, Amity Institute of Pharmacy, Amity University, Gurgaon, Haryana
8Associate, Hazard Communication Reckitt Benckiser (India) Pvt. Ltd. 6th & 7th Floor, Tower C, DLF Cyber Park-II, Udyog Vihar Phase-III Sector-20, Gurugram-122016 (HR)-India
9Irma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, Texas A&M University, Texas, USA

Recently, significant lifestyle changes have led to metabolic syndrome, anxiety, depression, and a decline in quality of life. Additionally, the combination of increased workload, ambitious career goals, and the desire to match or exceed others' socio-economic status often results in poor nutrition, which causes various health problems, fatigue, reduced strength, and stamina. Therefore, there is a clear need for nutritional supplements to address these issues. Shilajit and honey are two natural compounds from different sources that offer powerful nutritional benefits. Both are effective antioxidants and anti-inflammatories with considerable nutritional value. In this manuscript, we explore the chemical compositions, pharmacological activities, mechanisms of action, and health benefits of Shilajit and honey. Based on this, we suggest combining them for synergistic health effects. We also identify current gaps in regulation, safety, and toxicology studies, and emphasize the need for well-designed research. Furthermore, a clinical trial is needed to confirm the effectiveness of this formulation.

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Robin J. Thomson1, Dr. Sooraj S2, Aswathy P. Kumar3
1Principal & HOD, Dept of Shalyatantra, Mannam Ayurveda Cooperative Medical College,Pandalam
2Professor and HOD, Dept of Dravyagunavigyana, Mannam Ayurveda Cooperative Medical College, Pandalam
3Final year PG Scholar, Dept of Dravyagunavigyana, Mannam Ayurveda Cooperative Medical, Pandalam

Pain management in remains a critical challenge due to the risk of adverse effects associated with conventional analgesics. Herbal transdermal patches offer a promising, non-invasive, and targeted approach to pain relief, utilizing phytoconstituents with antiinflammatory and analgesic properties. This review explores the potential of herbal transdermal patches in managing musculoskeletal pain in athletes, analyzing their phytochemical composition, mechanism of action, and clinical efficacy through the lens of Ayurveda. Ayurvedic herbs) are known for their Vedanasthapana (analgesic) and Shothahara (anti-inflammatory) actions. A comprehensive search of scientific literature was conducted using databases such as PubMed, Scopus, and Google Scholar. Studies involving in vitro, in vivo, and clinical evaluations of herbal transdermal patches for pain management in sports-related injuries were analyzed. Ayurvedic literature and classical references were reviewed to validate the traditional use of these herbs. Several Ayurvedic herbs exhibit potent Vedanasthapana, Shothahara, and Sandhaneeya (wound-healing) properties Herbal transdermal patches based on Ayurvedic formulations provide a sustainable and effective alternative for pain management in athletes, minimizing systemic side effects while promoting faster recovery. Further clinical trials and standardization of formulations are essential to establish their widespread application in sports medicine.

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Dr. Komal Sharma1, Dr. Rakesh Kumar Sharma2
1Senior Medical Officer, MMM Govt Ayurved College Campus Hospital, Udaipur & P.hd Scholar, P. G. Department of Rachana Sharir, Post Graduate Institute of Ayurveda, Jodhpur (Rajasthan)
2Supervisor & Director, centre for Human Resource Development, Dr. SR. Rajasthan Ayurved University, Jodhpur (Rajasthan)

According to the World Health Organization (WHO), mental illness has become increasingly prevalent over the last decade, with one in eight adults experiencing mental health issues each year. This rise has led to greater interest in the relationship between diet and mental health, giving rise to the emerging field of nutritional psychiatry. This discipline emphasizes how dietary choices, and nutritional intake can significantly impact mental well-being and aims to support the treatment of mental health conditions through specific dietary and lifestyle changes. In this way, Ayurvedic dietary guidelines can hold great relevance today for promoting mental health and overall well-being. In Ayurveda, Ahara is recognized as a crucial aspect of health and is one of the three foundational pillars of the practice (Trayo-Upasthamba). The preventive and therapeutic principles of Ayurveda focus on Pathya Ahara and Vihara, which refer to a conducive diet and lifestyle regimen. Ayurveda provides comprehensive dietary guidelines, covering suitable food choices, compatible combinations, cooking methods, storage practices, dining environments, hygiene, and etiquette. A significant concept within Ayurveda is Viruddha Ahara, or food incompatibility, which is often cited as a primary cause of various mental disorders. The guidelines surrounding Pathya Ahara and Vihara address preventive, curative, and rehabilitative health aspects.

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Dr. Kalpana S. Wakode1*, Dr. Swetha Laxminarayana Vemula2
1Associate Professor, Shalakyatantra Department. Government Ayurved College, Nanded
2P. G. Scholar, Shalakyatantra Department, Government Ayurved College, Nanded

Ayurveda is the science that deals with different kinds of treatment modalities/Karmas. The importance of eye was emphasized in ayurveda by quoting eye as the most important of all the sense organs: “Sarvendriyanam madhye nayanasya pradhanatvath” [1]- eyes hold special status among all the sense organs. Of all the others, Netra, must be treated with great care. On the basis of Sadhyasadhyata, Acharya Sushruta divided the Netra Rogas into Aushadha Sadhya Vyadhis, Shastra Sadhya Vyadhis, and Asadhya Vyadhis. Nasya is very important in the Aushadha Sadhya Vyadhis. Nasya ‟being prime therapy for maintaining the health of Urdhvajatru”, because the only Karma, which finds a place in simple references like “Dinacharya” and the most sophisticated places like Panchakarma. The therapy of Netra Roga is decided using the Ama-Nirama principle of Sthanika Dosha. Nasya Karma is one of the Shodhana Karmas that can be used for this. Nasya is the noninvasive method that bypass the blood brain barrier and targets drugs to the central nervous system to treat neurodegenerative disorder as eye resides in head, thus Nasya can be one of the prime procedure to treat eye health and eye disorder.

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Dr. Ravinder Singh Khattra1
1Professor, Department of Shalya Tantra, Shaheed Kartar Singh Sarabha Ayurvedic Medical, College and Hospital, Sarabha, Ludhiana, Punjab, India

Nadi Vrana, a chronic and deep-seated sinus condition characterized by pus discharge and tract formation, closely resembles modern clinical conditions like fistula-in-ano and pilonidal sinus. In Ayurveda, the treatment of such disorders is described in detail, with KST emerging as a highly effective, minimally invasive and scientifically validated technique. This review aims to explore the role of KST in managing Nadi Vrana, highlighting its principles, pharmacological basis, clinical effectiveness and integration into modern surgical practice. Several clinical studies and randomized trials have demonstrated its superiority over conventional surgical interventions in terms of recurrence rate, patient comfort and postoperative recovery. The review also discusses contributions from the Central Council for Research in Ayurvedic Sciences and the scope of integrating this traditional technique into modern evidence-based medicine. Despite challenges in standardization and global acceptance, KST remains a promising and sustainable approach for managing chronic sinus conditions like Nadi Vrana.

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Ashif Iqubal1, Sayed Abdur Rehman2, Ferooz Ahmad3, Anu Mahajan4, BDS Bedi, Tanuja Singh5, Abdul Qadir*
1Research and Development Advisor, Herbified Healthcare, New Delhi-110020, India
2Research and Development Executive, Herbified Healthcare, New Delhi
3Director, Kashmir Food & Wellness Products, Village Gundbal, near Cricket Ground, Pampore, Jammu and Kashmir
4Senior Research Fellow, PhD scholar, Symbiosis School of Culinary Arts and Nutritional Science (SSCANS), Pune
5Centre for Interdisciplinary Research for Basic Science (CIRBSc), Ramanjun Block, Jamia Millia Islamia, New Delhi

Shilajit is an ancient herbomineral compound with rich traditional uses. However, recently, extensive scientific research has been conducted to validate its health benefits, confirming its efficacy and safety. Shilajit contains fulvic acid, along with various other compounds, such as polyphenols, trace elements, minerals, and more. The combination of these natural components makes this herbo-mineral compound a powerful antioxidant and anti-inflammatory agent. It is also important to note that the current use of Shilajit is mostly limited to men for overall well-being, immune boosting, and enhancing endurance, strength, and stamina. Additionally, different formulations of Shilajit are available to promote calming effects, aid with insomnia, sexual dysfunction, and more. Notably, women still face barriers in using Shilajit due to its explicit claims related to men's sexual health. As a result, many women do not benefit from this remarkable natural compound. In this manuscript, we discuss the scientific evidence supporting the use of Shilajit for women. We have compiled data from both preclinical and clinical studies to explore its potential benefits for females.

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Maneesha KS1, Reeshma CR2, Sreedevi AP3, Shari Sankar4, Veena K5
1Jr. Officer, R & D Department, Sitaram Ayurveda Pvt. Ltd., Kerala, India
2Jr. Chemist, R & D Department, Sitaram Ayurveda Pvt. Ltd., Kerala, India
3Research Officer, R & D Department, Sitaram Ayurveda Pvt. Ltd., Kerala, India
4Chief chemist, QC Department, Sitaram Ayurveda Pvt. Ltd., Kerala, India
5Senior Microbiologist, QC Department, Sitaram Ayurveda Pvt. Ltd., Kerala, India, Corresponding Auhtor: Dr. Sreedevi. A P, Research Officer, R& D Department Sitaram Ayurveda Pvt. Ltd., Kerala, India

Introduction: Inflasap, an Ayurvedic tablet with 17 herbal ingredients comprising of Alpinia galanga and Boswellia serrata, etc. targets inflammation using traditional principles. This study assesses its quality, safety, and efficacy as per Ayurvedic Pharmacopeia standards. Materials and Methods: Herbal raw materials,were processed into tablets and evaluated for organoleptic, physicochemical, microbial, heavy metal, and GC-MS properties. Results: Inflasap showed, stable physicochemical properties (1000 mg ± 5%, friability ≤1%), no pathogens, safe heavy metal levels (lead: 0.22 ppm, arsenic: 0.45 ppm), and 15 anti-inflammatory phytoconstituents (e.g., Oxirane: 69.844%). Discussion: The results collectively validate Inflasap’s quality, safety, and therapeutic potential. Its sensory and physicochemical properties ensure consumer acceptability and product stability, while microbial and heavy metal analyses confirm safety for oral administration. The GC-MS findings support the anti-inflammatory efficacy of its herbal ingredients, aligning with traditional Ayurvedic claims. Conclusion: Inflasap adheres to Ayurvedic Pharmacopeia standards, demonstrating robust quality, safety, and potential as an anti-inflammatory formulation. Its rich phytoconstituent profile underscores its therapeutic promise.

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Dr. Himani Sharman1, Dr. Shakshi2, Dr Anjali Rai3
1Associate professor, Department of Agada Tantra and vidhi vaidyak, Babe ke ayurvedic medical college and hospital, Moga, Punjab
2Assistant professor, Department of PTSR, Patanjali bhartiya Ayurvigyan evum Anusandhan Sansthan, Haridwar
3Assistant professor, Department of Kriya Sharir, Babe ke ayurvedic medical college and hospital, Moga, Punjab

Cancer therapies such as chemotherapy and radiotherapy are effective in treating malignancies but are associated with a wide range of adverse effects, including hematological, gastrointestinal, dermatological, neurological, and immunological toxicities. These side effects significantly affect patients' quality of life and may lead to treatment discontinuation. Ayurveda, the traditional Indian system of medicine, offers holistic, individualized approaches that can support recovery and mitigate treatment-induced toxicity. This article explores the toxicities caused by cancer therapies and presents Ayurvedic interventions such as Rasayana therapy, herbal support, Panchakarma procedures, and lifestyle modifications as potential complementary therapies. Evidence-based research supporting the use of Ayurvedic herbs like Ashwagandha, Guduchi, and Triphala is also reviewed. Integrating Ayurveda into conventional oncology may improve therapeutic tolerance, enhance recovery, and promote overall well-being.

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