The microbial pullulan as therapeutic tool in Medicine

In general, the body tissue is composed of cells with the local environment that plays an essential role in the attachment, proliferation, migration or differentiation of cells in the 3-dimensional organization. The cell behaviour is influenced by the surface and bulk properties of substrates like bio compatible inert material. Pullulan is one of the bio polymer which is frequently used in pharmaceutical, food and cosmetics industries. This polymer helps in fast dissolving drug delivery system which is suited for the drugs that undergoes highly first pass metabolic process and is used for enhancing the bioavailability with the reduction of dosage frequency. A glucose-based polysaccharide basically pullulan, has been shown to have a slow rate of hydrolysis in both the raw and cooked state at in vitro and in vivo conditions. The various types of inert bio-conjugates having anti-cancer and anti-inflammatory properties were synthesised by pullulan derivatisation and surface modifications. In the present review, recent advancements and literature regarding health sciences, medicine and the pharmaceutical approaches has been discussed.