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International Journal ofAyurvedic and Herbal Medicine
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Hepatoprotactive activity of Aqueous Extract of Syzygium cumini Seed on Streptozotocin Induced Diabetes in Rats

Published:25 Apr 2014
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Swadhin Ranjan Behera1*, Sekkizhar M2, Sarath Babu. K3

1 Assistant Professor, Department of Pharmacology, Rajah Muthiah Medical College and Hospital, Annamalai University, Annamalainagar, Tamil Nadu.

2 Professoor, Department of Pharmacology, Rajah Muthiah Medical College, Annamalai University, Tamil Nadu.

3 Assistant Professor, Department of Pharmacology, Sree Mookambika Institute of Medical Sciences, Kulasekharam, Kanyakumari, Tamil Nadu.

Corresponding Author:Swadhin Ranjan Behera

picture_as_pdfDownload link10.47191/ijahm/v4i2.04

subjectAbstract

The effects of aqueous seed extract of Syzygium cumini (S.C) on hepatoprotection in streptozotocin (STZ) - induced diabetic rats were investigated. G-A serves as control, G-B serves diabetic control, G-C administered standard oral hypoglycemic drug, G-D and E administered two graded doses of seed extract. STZ was administered to rats after 72 hours blood glucose was estimated. Rats showed more than 200mg/dl glucose level considered in to diabetic rats. The selected diabetic rats were divided in to G-B, C, D and E. The G-B considered diabetic control group and G-C, D and E groups given their respective drugs for 120 days. On 120th day blood was collected from the all the groups and liver enzymes like AST, ALT, ALP, GGT were estimated by using auto-analyzer. Study results showed increased liver enzymes in G-B compared to all the groups. Standard and S.C_500mg/kg groups showed significant decrease in liver enzymes compared to other groups. Low dose of seed extract had less protective effect compared to high dose. From the study results, it can conclude that administration aqueous extract of S.C seed powder showed liver protective effect. There is requirement of more studies to isolate active compound form the seed powder.

sellKeywords

DiabetesGlibenclamidehepatoprotectiveInsulinStreptozotocinSyzygium cumini

format_list_numberedReferences

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How to Cite

Behera, S. R., M, S., & K, S. B. (2014). Hepatoprotactive activity of Aqueous Extract of Syzygium cumini Seed on Streptozotocin Induced Diabetes in Rats. International Journal of Ayurvedic and Herbal Medicine, 4(2). https://doi.org/10.47191/ijahm/v4i2.04

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