Volume 11, Issue 4

- The large intestine is called as Pakwashaya. The large intestine extends from the ileoceal junction to anus. It is about 1.5 metres long, 6.5 cm in diameter. It is divided into caecum, appendix, rectum, ascending colon, descending colon, transverse colon, and anus. It is the one of the site of Vaat dosha in our body. The Gut Brain Axis describes the two-way connection and communication between gut and the brain. The gut has its own nervous system called as enteric nervous system (ENS) which is located in sheath of tissue lining the oesophagus, stomach, small intestine and colon. Hundreds (100) trillions off neurons in gut which is present it is more than brain and spinal cord. Therefore, what is happening in the Gut can directly influence our brain function and behaviour. During embryonic system, the chunk of tissue from which CNS is formed this tissue is called as neural crest. Any miscommunication between this two-way system can bring about a range of health conditions such as irritable bowel syndrome (IBS), depression, anxiety, and obesity. Correlations of concept of Pakwashaya and Gut-Brain Axis have positive answer and will help in diagnosis, prognosis and treatment. Keyword – Pakwashaya, Gut Brain Axis, Enteric Nervous System