arrow_backBack to Issue

A Comparative Review on Medicinal Plants Used For The Treatment of Liver Disorders As In Ayurved, Siddha And Unani [Asu] Systems of Medicine- Part I- Contextual And Clinical Aspects

Published:13 Sept 2014
visibility0 Viewsdownload0 Downloads
Dr. Bhatt Narendra1, Dr. Deshpande Manasi2

1 Consultant- Ayurveda, Research & Industry, CRIA Consultants Pvt. Ltd

2 Professor and Head, Department of DravyagunaVigynan, Bharati Vidyapeeth [Deemed to be

subjectAbstract

In recent times the liver dysfunction has gained significant importance as a precursor and for a broad range of metabolic disorders. Both, chronic and acute liver diseases irrespective of age, sex, region or race are the major cause of morbidity and mortality across the world. Natural products are used and examined for various types of liver disorders. Large number of compound formulations and single drugs from Ayurved, Siddha and Unani systems are commonly used without much adverse effects to manage a variety of liver disorders. Various liver diseases are described in Ayurveda, Unani and Siddha systems that are explained in the light of presently available biomedical information. This review is outcome of a systematic effort and analyses of hepatoprotective formulations and ingredients particularly in the context of contextual and clinical information and research undertaken. An attempt has been made to shortlist twenty-five (25) potential medicinal plants out of 106. The enlistment of these 25 plants with relevant updated information as compiled and categorised will provide insights to choose possible treatment approaches and to examine further potentials. This review can help enhance translational research by connecting fundamentals of traditional systems with the modern scientific parameters and thereby reducing the screening time, efforts and costs.

sellKeywords

Liver disordersAyurvedSiddhaUnaniMedicinal plants

format_list_numberedReferences

  1. Murray CJ, Lopez AD. Evidence-based health policy – lessons from the Burden of Disease Study. Science 1996; 274: 740-743.
  2. Abdulrahman K. et al. A Review of Hepatoprotective Plants Used in Saudi Traditional Medicine, Evidence-Based Complementary and Alternative Medicine, vol. 2014, https://doi.org/10.1155/2014/890842
  3. https://timesofindia.indiatimes.com/life-style/health-fitness/health-news/is-liver-disease-the-next-major-lifestyle-disease-of-india-after-diabetes-and-bp/articleshow/58122706.cms, April 11 2017, accessed April 2021
  4. Mukherjee PS, Vishnubhatla S, Amarapurkar DN, Das K, Sood A, Chawla YK, et al. (2017) Etiology and mode of presentation of chronic liver diseases in India: A multi centric study. PLoS ONE 12(10): e0187033. https://doi.org/10.1371/journal.pone.0187033
  5. Dienstag JL, Isselbacher KJ, Toxic and drug induced hepatitis, 15th edn. Chapter 296, In Harrison’s Principles of Internal Medicine. Braunwald E, et al, The McGraw-Hill Companies, 2007; 2:737-1742
  6. Bhatt AD, Bhatt NS. Indigenous drugs and liver disease. Indian J Gastroenterol.1996; 15: 63-67
  7. Valvi AR, Mouriya N, Athawale RB, Bhatt NS. Hepatoprotective Ayurvedic plants - a review. J Complement Integr Med. 2016 Sep 1;13(3):207-215. doi: 10.1515/jcim-2015-0110. PMID: 27310002.
  8. Bhatt N. & Deshpande M. (2018). Int J Ayu Pharm Chem Liver Disorders and Potential Medicinal plants: A Review Study. 2018; 9 (10).10.13140/RG.2.2.15990.45120
  9. Bhatt N, Deshpande M, Namewar P and Pawar S: A review of classical, proprietary and patented Ayurved products and their ingredients in liver/sleen diseases. Int J Pharm Sci & Res.2018; 910: 4056-70. doi: 10.13040/IJPSR.0975-8232.910.4056-70
  10. Narendra Bhatt, Dr. Sudha Revathy, Dr. Manasi Deshpande A Review of Siddha Traditional System Products and Their Ingredients in Liver Diseases, International Journal of AYUSH; 2020: 9 (2);55-74
  11. http://ayush.gov.in/sites/default/files/Introduction_2.pdf, assessed on 10 April 2021
  12. Sangeeta Rongson, Niten Barman. A Conceptual Study of Raktavaha Srotas and its Disease. International Journal of Ayurveda and Pharma Research.2017; 5(6):89-95.
  13. Panda AK, Bhuyan GC, Rao MM. Ayurvedic Intervention for Hepatobiliary Disorders: Current Scenario and Future Prospect. J Tradit Med Clin Natur. 2017; 6:210.
  14. Kashinath Pandey, Dr. Gorakhnath Chaturvedi, edited by Pt. Rajeshwardutt Shashtri, Charak Samhita- SavimarshVidyotini Hindivyakhyopeta, Chaukhambha Bharati Academy, Varanasi, Reprint 2008, Vimansthan, chapter 5, verse 7, page 711
  15. Sushruta, Sushrut Samhita, with commentary of Dalhana, Edited by Vaidya Jadavaji Trikamji, Chaukhambha Orientalia, Varanasi, 8th Edition, 2005, Sutrasthana, Chapter 14, verse 4,page 59
  16. Lad, Vasant, M.A.Sc., Textbook of Ayurveda Fundamental Principles. 2002; p. 57-58
  17. https://www.nhp.gov.in/ayurvedic-perspective-of-liver_mtl, assessed on 21 April 2121
  18. Balachandran P., Govindrajan R. Cancer – an ayurvedic perspective. Pharmacol Res 51(2005)19-30
  19. Deka D. Cirrhosis of liver: Review from Ayurvedic literature. J Ayu Herb Med 2017; 3(2):98-101.
  20. S. Mohamed Saleem, C. Madhusudhana Chetty, S. Ramkanth, V.S.T. Rajan, K. Mahesh Kumar, & Gauthaman K. Hepatoprotective Herbs – A Review. International Journal of Research in Pharmaceutical Sciences, 2010;1(1), 1-5. Retrieved from https://pharmascope.org/ijrps/article/view/78.
  21. Rane Jesika, Jadhao Rajesh, Bakal R. L. Liver diseases and herbal drugs: -A review Journal of Innovations in Pharmaceuticals and Biological Sciences. 2016; Vol 3 (2), 24-36.
  22. Kasar NV, Deole YS, Tiwari S, Systematic review of the concept of Yakrutotpatti (embryology of liver), 2014 Jan;35(1):5-8
  23. Yan Li and Robert C. G. Martin, II, Herbal Medicine and Hepatocellular Carcinoma: Applications and Challenges, Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 541209, 14 pages, 201
  24. nhp.gov.in/kalleeral-noi-liver-disease_mtl, assessed on 30 april 2021
  25. Ponniahsamy G , Shree Devi M S, Vasudevan R and Muralidass S D, Hepatoprotective medicinal plants of Siddha – A review, World J Pharm Sci 2015; 3(9): 1921-1924
  26. S Hepato-protective herbs and medicines in siddha system of medicine-a review. Journal of Pharmacognosy and Phytochemistry 2017. 6(5):2246-2251
  27. Shanmugapriya P , Sivaraman D , Christian GJ , Rajalakshmi K , Jeeva Gladys R,Hepatoprotective Potential of Novel Siddha Formulation Santha Santhrodhaya Mathirai against Paracetamol and Methotrexate Induced Hepatotoxicity in Chang liver Cell line Model , J. Pharm. Sci. & Res. 2019; Vol. 11(6), , 2379-2384
  28. Prakash, G. Anitha , J. Nisha , N. J. Muthu kumar and V. Banumathi, A Role Of Siddha Medicines in The Management Of Hepatic Disease - A Systematic Review, European Journal of Biomedical and Pharmaceutical sciences, 2018, Volume 5, Issue 3 265-267.
  29. P, Ramalingam.S, Saranya.K, Thangaraj.K, Kanakavalli.K and Thillaivanan.S, A Review on Hepatoprotective Herbs In Siddha System of Medicine, International Journal of Pharmaceutical Archive. 2014 - 3 (9), Sept. - 2014
  30. Ehsan et al. Clinical Study on Warm-E-Kabid. M.D thesis, Faculty Of Medicine, Jamia Hamdard, New Delhi, 2005;10-20.
  31. Tabri ABR. Al-Moalejaat Buqratiya. 3rd volume. New Delhi, Central Council for Research In Unani Medicine, 1997;197-217.
  32. Tabri R. Firdausul Hikmat (Urdu). Volume 1 & 2. Lahore, Sheikh Mohammad Bashir & Sons, 1997; 206-210.
  33. Shabnam Ansari, Mohammad A Siddiqui, Therapeutic Effect Of A Unani Formulation On Hepatitis B Surface Antigen In Chronic Hepatitis B: A Case Series, Asian J Pharm Clin Res. 2015; Vol 8, Issue 5, 76-78
  34. Shabnam Ansari1, Mohammad Akhtar Siddiqui, Fasihuz , Zaman. Therapeutic Principles of Liver Diseases In Unani Medicine, J Res Educ Indian Med. 2015; Vol. XXI,101-105. doi:10.5455/JREIM.82-1420026640
  35. Hoosen M, Temperament – an important principle for health preservation in Tibb an-Nabawi and Unani-Tibb, Bangladesh Journal of Medical Science Vol. 16 No. 04 October’17
  36. Mohammad Akhtar Siddiqui, Shabnam Ansari. Unani treatment improved fibrosis in decompensated cirrhosis of liver: A case series. Journal of Advances in Internal Medicine 2015;04(02):61-66
  37. AFI: Ayurvedic Formulary Of India, Vol I-III, 1st Edition Delhi (IN): Government Of India, Ministry Of Health And Family Welfare, Department Of Ayurveda, Yoga & Naturopathy, Unani, Siddha And Homoeopathy.2000, 2003, 2011
  38. SFI, Siddha Formulary of India, 1st Edition Delhi (IN): Government Of India, Ministry Of Health And Family Welfare, Department of Indian Systems Of Medicine & Homoeopathy. 1992
  39. UFI: The Unani Pharmacopoeia of India, Part II (Formulations) , Vol I-IV, 1st Edition Delhi (IN): Government Of India, Ministry of Health And Family Welfare, Department Of Ayurveda, Yoga & Naturopathy, Unani, Siddha And Homoeopathy.2009,2010,2016,2019
  40. NFUM: National Formulary of Unani Medicine, Part I-VI, 1st edition Delhi (IN): Government of India, Ministry of Health and Family Welfare, Department of Indian Systems of Medicine & Homoeopathy. 1984,1994, 2001, 2006, 2008, 2011
  41. API: The Ayurvedic Pharmacopoeia of India, 1st Edition, Part I, Delhi (IN): Government of India, Ministry of Health And Family Welfare, Department of Ayurveda, Yoga & Naturopathy, Unani, Siddha and Homoeopathy.1986, 1999, 2001, 2004; Volume I-VI. doi:10.5455/JREIM.82-142002664006
  42. API:: The Ayurvedic Pharmacopoeia of India, 1st Edition Part II (Formulations) Delhi (IN): Government of India, Ministry of Health and Family Welfare, Department of Ayurveda, Yoga & Naturopathy, Unani, Siddha and Homoeopathy. 2007,2008,2010,2017; Vol- I-IV
  43. SPI: Siddha Pharmacopoeia of India, Part I, 1st Edition Delhi (IN): Government of India, Ministry of Health And Family Welfare, Department of Ayurveda, Yoga & Naturopathy, Unani, Siddha and Homoeopathy. 2008,2011; Vol I-II,
  44. UPI: The Unani Pharmacopoeia of India Part-I. 1st Edition Delhi (IN): Government of India, Ministry of Health And Family Welfare, Department of Ayurveda, Yoga & Naturopathy, Unani, Siddha and Homoeopathy. 2007, 2008, 2009; Vol I-IV
  45. Essential drug list [EDL], Ayurved, Delhi (IN): Government of India Department of AYUSH, Drug control cell, Ministry of Health and Family Welfare, Department of AYUSH;
  46. Essential drug list [EDL], Unani Medicine, Delhi (IN): Government of India Department of AYUSH, Drug control cell, Ministry of Health and Family Welfare, Department of AYUSH;
  47. Essential drug list [EDL], Siddha Medicine, Delhi (IN): Government of India Department of AYUSH, Drug control cell, Ministry of Health and Family Welfare, Department of AYUSH;
  48. Perspectives of Indian Medicinal Plants in the Management of Liver Disorders, Indian Council of Medical Research; 2008 edition (April 1, 2008)
  49. Yasui S, Fujiwara K, Tawada A, Fukuda Y, Nakano M, Yokosuka O. Efficacy of intravenous glycyrrhizin in the early stage of acute onset autoimmune hepatitis. Digestive Diseases and Sciences. 2011;56(12):3638–3647
  50. Manns, Michael et al. Glycyrrhizin in patients who failed previous interferon alpha-based therapies: Biochemical and histological effects after 52 weeks. Journal of viral hepatitis. 2012; 19. 537-46. 10.1111/j.1365-2893.2011.01579.x
  51. Ikeda K. Glycyrrhizin injection therapy prevents hepatocellular carcinogenesis in patients with interferon-resistant active chronic hepatitis C. Hepatology Research. 2007;37(2):S287–S293
  52. Annie George, Jay K. Udani & Ashril Yusof . Effects of Phyllanthus amarusPHYLLPROTM leaves on hangover symptoms: a randomized, double-blind, placebo-controlled crossover study, Pharmaceutical Biology. 2019;57:1, 145-153,
  53. Xia Y, Luo H, Liu JP, Gluud C. Phyllanthus species for chronic hepatitis B virus infection. Cochrane Database Syst Rev2011;4
  54. Manish V. Patel, Kalapi B. Patel, Shivenarain Gupta, Andreas Michalsen, Elmar Stapelfeldt, and Christian S. Kessler, A Complex Multiherbal Regimen Based on Ayurveda Medicine for the Management of Hepatic Cirrhosis Complicated by Ascites: Nonrandomized, Uncontrolled, Single Group, Open-Label Observational Clinical Study. Evidence-Based Complementary and Alternative Medicine. 2015
  55. Padmaja S. Nikam, Shashikant V. Nikam, Ajit V. Sontakke, Chitra C. Khanwelka. Role of Phyllanthus amarus treatment in Hepatitis-C. Biomedical Research. 2011; Volume 22, Issue 3
  56. Tomar GS, Singh RN, Treatment of hepatocellular jaundice with Kalmegh [Andrographis paniculata Nees. , Aryavaidyam. 1990;11 , 156-162
  57. Patel, Jitendra S., Clinical Trials of Eclipta Prostrata (L.)L as Hepatoprotective and Their Market Formulations, 2009; thesis PhD, Saurashtra University
  58. Arase Y, Ikeda K, Murashima N, et al. The long term efficacy of Glycyrrhizin in chronic hepatitis C patients, Cancer. 1997;79(8):1494–1500
  59. Chturvedi GN, Tomar GS, Tiwari SK, Singh KP. Clinical studies on kalmegh (andrographis paniculata nees) in infective hepatitis Anc Sci Life.1983 Apr; 2(4):208-15.
  60. Wang H-F, Su H-B, Liu H-L, et al. Clinical research on treatment on several kinds of liver hepatitis with diammonium glycyrrhizinate. Chinese Journal of Infectious Diseases. 2004; 22(2):113–115.
  61. Dixit SP, Anchar MP, Study of Bhringraja [Eclipta alba] therapy in Jaundice in children. J. SCI Res Plant Med 1981, 2 [4], 96-100
  62. S Ganesh, Pralhad S Patki, SK Mitra, Clinical evaluation of a herbal formulation in liver disorders, Australian Journal of Medical Herbalism. 2009 21(1)
  63. Patel, H. J.et al, Clinical study of hepatoprotective drug Phyllanthus amarus.Research Journal of Pharmaceutical Biological and Chemical Sciences. 2010 Vol.1 No.2 pp.335-340
  64. Panahi Y, Kianpour P, Mohtashami R, Jafari R, Simental-Mendía LE, Sahebkar A, Efficacy and Safety of Phytosomal Curcumin in Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial. Drug Res (Stuttg). 2017 Apr; 67(4):244-251.
  65. Rahmani S, Asgary S, Askari G, Keshvari M, Hatamipour M, Feizi A, Sahebkar A Treatment of Non-alcoholic Fatty Liver Disease with Curcumin: A Randomized Placebo-controlled Trial.Phytother Res. 2016 Sep; 30(9):1540-8.
  66. Kesarwani K, Gupta R, Mukerjee A. Bioavailability enhancers of herbal origin: an overview. Asian Pac J Trop Biomed. 2013; 3(4):253–266.
  67. Abdel Salam, S Nofal, S El-Shenawy, N Shaffie. Effect of Piperine On Liver Damage And Bone Changes Caused By Bile Duct Ligation In Rats. The Internet Journal of Pharmacology. 2007; Volume 5 Number
  68. Subramani Parasuraman, GanSiaw Thing, and Sokkalingam Arumugam Dhanara. Polyherbal formulation: Concept of Ayurveda, Pharmacogn Rev. 2014 Jul-Dec; 8(16): 73–80

How to Cite

Narendra, D. B. & Manasi, D. D. (2021). A Comparative Review on Medicinal Plants Used For The Treatment of Liver Disorders As In Ayurved, Siddha And Unani [Asu] Systems of Medicine- Part I- Contextual And Clinical Aspects. International Journal of Ayurvedic and Herbal Medicine, 11(5). https://doi.org/10.47191/ijahm/v11i5.04

APA

American Psychological Association Style