Volume 14, Issue 6

Herbal plants have long been used in traditional medicine to address and heal a wide range of health-related issues. Withania coagulans (Family; Solanaceae), a valuable medicinal plant used to evaluates bioactives by using maceration. Phytochemical analysis evaluated by qualitatively for five different extract. Methanol extract has highest phytocostitutents so further used for analysis phenolic compounds (86.67 ± 3.19 mg GAE/g) and flavonoids (60.95 ± 2.70 mg QE/g). The methanol extract demonstrated significant antioxidant activity in the DPPH and FRAP assay with IC50 value 63.02±1.08 μg/ml and 70.2±1.11 μg/ml respectively and notable antibacterial activity against Escherichia coli and Staphylococcus aureus. Additionally, the methanol extract exhibited substantial anti-diabetic potential, with IC50 value 602.6±2.98 μg/ml. This study demonstrated that the methanolic extract of Withania coagulans is a potent natural antioxidant, which could be beneficial in slowing the progression of various oxidative stress-related conditions.

Shirodhara, an integral practice in Ayurvedic medicine, involves the continuous pouring of warm, herbal-infused oil over the forehead, primarily aiming to harmonize the body's physiological systems. While traditionally known for its therapeutic benefits in stress relief and mental clarity, Shirodhara also offers a multitude of cosmetic advantages. This review explores the cosmetic benefits of Shirodhara, focusing on its role in promoting scalp health, stimulating hair growth, and enhancing overall skin appearance. The treatment’s efficacy in reducing stress and improving sleep quality plays a pivotal role in mitigating stress-induced cosmetic conditions such as acne, premature aging, and hair loss. By lowering cortisol levels, Shirodhara supports a healthier complexion and stronger hair. Enhanced blood circulation from the warm oil's continuous flow ensures that more nutrients and oxygen reach the scalp and skin, promoting cell regeneration and repairing damaged tissues. Herbal oils like Bhringraj, Amla, and Coconut oil used in Shirodhara strengthen hair follicles, deeply moisturize the scalp, and combat dryness and dandruff. These oils are rich in antioxidants and essential nutrients that fortify the hair shaft, leading to thicker, more resilient hair. The treatment’s balancing effect on hormonal levels also addresses issues like melasma, hirsutism, and cystic acne. Additionally, the deep conditioning effect of the oils enhances skin elasticity, reduces fine lines and wrinkles, and imparts a youthful glow, while improved lymphatic drainage helps detoxify the skin, reduce puffiness, and prevent dark circles. In conclusion, Shirodhara provides a holistic approach to enhancing cosmetic health by integrating stress reduction, hormonal balance, and targeted scalp and skin care, making it a valuable practice in both traditional and modern beauty therapies.

The specialized branch of Ayurved, Rasashastra is focusing on using metals, minerals, and herbs to create potent medicines. Rasaratnakara, written in the 13th century, is a key text in Indian alchemy, detailing the practice of producing gems. It offers a blend of theoretical knowledge and practical experience, explaining Dehavada and Lohavada in depth. The content of the text material is divided into five segments, referred to as Khanda, which include Rasa, Rasendra, Vadi or Riddhi, Rasayana, and Mantra. Each Khanda comprises multiple chapters known as Upadesha. It thoroughly explores the two fundamental ideas of Rasashastra in significant detail, providing an in-depth comprehension of alchemical processes.

Background: Ayurveda is not just a science of life; it is also a method for improving human health. This ancient practice from India is a special legacy utilized for health and wellness. Technology is important for spreading Ayurveda globally and helping people to accept and use it in their lives. Ais and objective: To understand the role of technology in the upliftment and standardization of Ayurveda. Material and Methods: The various primary and secondary data available in different books, journals, and internet sites are analyzed and prepared. Discussion: The addition of technology into the practice of Ayurveda does not only raise the standards of practice of Ayurveda. It aids in the dissemination of the practice of Ayurvedic medicine all over the world. To promote it as a universal system of medicine and to prepare Ayurveda for unimaginable 21st-century global healthcare requirements, it is crucial to modify the ancient practice in line with emerging science and technology. From all the above, it can be understood that restructuring of Ayurveda may be necessitated by present-day demands of a cyber society wherein information and communication technology will be applied. The present review is also concerned with some of the areas of Ayurveda where the technology can be incorporated with the help of a few examples.

Aim- To collect and comprehensively review information available regarding the medicinal use of Amra. Background- Amra [Mangifera indica Linn.] has been used in traditional medicine for the treatment of different disease. It contains tannins, pyrogallotannins, mangiferin and also contains vitamin A and C. It shows Anticancer, Anti-diabetic, Anti-inflammatory, laxative action. In various nighantus properties of amra and its different part have been explained. Though there are few review articles available on this plant but no review has comprehensively covered all aspects of Amra. Materials And Methods- This review is in a narrative format and done from literature and publications relevant to Amra that were identified through a systematic search of major computerized medical databases. Review Results- Amra [Mangifera indica Linn.], was reviewed from all samhitas and Nighantu’s and from more than 55 research articles for medicinal uses and other important aspects. Conclusion- Amra is concluded to have more than 20 Samhita based indications Rakta-rodhaka, Vranaropaka, Stambhana, Garbhashay-ashothahara (Bark); Rakta-rodhaka, Vrana-ropaka, Chhardi-nigrahana (Leaf); Vrana-ropaka, Mootra-sangrahaniya, Stambhana (Flower); Rakta-rodhaka, Stambhana, Krimi-ghna, Vrana-ropaka Garbhashaya-shothahara (Seed kernel); Snehana, Anulomana, Saraka, Balya, Varnya, Brinhana, Vrishya, Hridya, Shonita-sthapana (Ripe fruit); Daha-prashamana (Unripe fruit- Roasted); Rochana, Deepana, Pachana, Raktapitta- prakopaka (Unripe fruit Unroasted). Amra also possesses anticancer, anti-diabetic, anti-inflammatory properties, hepatoprotective, anti-hemorrhagic, anti-tetanus, analgesics and antipyretic, kidney damage, anti-ulcer, lipid profile, anti-bone-resorption, anti-diarrheal, antibacterial, anti-fungal, anti-viral, anti-amoebic, anthelmintic, anti-malarial, radio-protective, immunomodulation, cardio-protective, osteoporosis prevention, recognition of memory, broncho-dilatory and laxative effects. Clinical Significance- Samhita based indications of Amra are compared with Article concluded effect and then areas of further research are identified in drug Amra . KEYWORD : Ayurveda, Amra, Mangifera indica.

Anjana is an Ayurvedic medicinal formulation that is used in “Sampakvadosha” condition.1 Anjana also known as collyrium is a topical application of drug in the form of smooth paste into the conjunctival fornices with an applicator. Although Anjanas are meant for eye diseases yet it has wide application in systemic diseases too. Anjana is used when the acute inflammatory features subside and the clinical feature of each dosha become manifested and localized in the eye. Anjana preparation are compound drugs prepared out of metal, minerals, herbs and animal materials. Generally Arsenic, Antimony, Lead and Tin compounds are frequently prescribed. Dosage and duration are aptly prescribed to avoid noncompliance. Disposal of the drug is very minimal so the tissue contact time is more; absorption is maximum thus bioavailability is naturally more. Probably, it acts as subconjunctival injection, permeability is also possible through the sclera and enters into the systemic circulation and may act on posterior segmental disorders of the eye. The metals in Anjana preparation having larger molecular weight do not cross the blood aqueous barrier when administered systematically. The treatment plan of Praklinna Vartma mentioned in Sushruta Samhita includes Yoganjana along with other ocular therapeutic procedures. Yoganjana is an Ayurvedic formulation mentioned in Sushruta Samhita used to treat Vartmagata disease namely Praklinna Vartma. Keeping all the points, this study has been undertaken with the aim to modify Yoganjana in ointment form. The Anjana was prepared through “Ghana Satva Kalpana”. KEYWORD : Yoganjana, Analytical Study, Praklinna Vartma, Seborrhoeic Blepharitis.

Kundur, the Indian olibanum tree, is a member of the Burseraceae family and grows best in the dry mountainous regions of the Middle East, Northern Africa, and India. This tree has small to huge branches. The tree's oleo-gum resin is removed and stored from the incision created in its trunk. Resin makes roughly 30–60% of oleo-gum resin, with organic solvent-soluble essential oils making up the remaining 5–10%. Gum-resin extracts from Boswellia serrata have long been used in traditional medicine to treat a variety of chronic inflammatory diseases. Four primary pentacyclic triterpenic acids found in the resinous component of Boswellia serrata are β-boswellic acid, acetyl-β-boswellic acid, 11-keto-β-boswellic acid, and acetyl-11-keto-β-boswellic acid. This oleo-gum resin is quite popular among traditional practitioners of traditional Chinese and Indian Systems of medicine because of its wide range of useful biological properties such as anti-inflammatory, anti-arthritic, anti-rheumatic, anti-diarrheal, anti-hyperlipidemic, anti-asthmatic, anti-cancer, anti-microbial, anti-fungal, anti-complementary, and analgesic activity etc. KEYWORD : Kundur, Boswellia serrata, Unani, oleo-gum resin, Anti-arthritic

Madya is consider as alcohol in Ayurveda. Madya is mentioned in Brihattrayi and Laghuttrayi. According to Ayurveda if Madya is taken in proper manner and dose act as nectar (Amrit). If it is taken in excess doses it produces Mada (acute alcoholism) Madatyaya or Panatyaya (chronic alcoholism) and Panavibhrama (Alcohol withdrawal syndrome). There is no single cause of Alcoholism. Alcohol withdrawal is a set of symptoms seen after the cessation of heavy usage of Alcohol lasts to 24 hours to 72 hours and need a proper care. The symptoms varies person to person like insomnia, nausea, vomiting, headache, hallucinations, tremors, seizures and even leads to death. Various treatment modalities like Shodana and Shaman explained in Ayurveda to treat Madatyaya. They need proper nutritional supplementation in proper manner and should provide immediate nourishment to control the condition. Here the combination of 7 drugs which are rich in vitamins nutrients and minerals explained in authenticate text book of Ayurveda made in to syrup form for easy administration and storage and which effective in Madatyaya. KEYWORD : Madatyaya, Alcohol Withdrawak syndrome, Kharjuradi Mantha Syrup.

Ancient acharya of ayurveda has given great emphasize on intake of aahara-ras as best source for nourishment that play prime role in growth and development of embryo/foetus during pregnancy. To achieve a healthy progeny, ayurvedic science have illuminated wholesome regimen, that should be follow by the parents before and after conception. They have also elucidate about six specific procreating factors- Shad bhav (matruja, pitruja, atmaja, rasaja, satmyaja and satwaja) which are responsible for the growth of embryo. Among six factors rasaja bhava plays an important role in providing nutrition to the foetus. The concept of Upasneha, Upasweda, Ambu, Apara and Nabhinadi are involved in nourishment of embryo/foetus at different stages of development. Anceint science have drawn attention to certain food habits (aahar ras vikriti), to be avoided by the pregnant woman to refrain from abnormalities, deformities in the offspring. The concept of nutrition (aahar ras-rasaj bhav) in garbhini explained in ancient classics KEYWORD : Aahar-ras, Shadbhav, Garbhaj-vikriti.

In Ayurveda, the treatment of Chronic Kidney Disease (CKD) is approached through a holistic lens, where the focus lies not just on alleviating symptoms but also on restoring balance to the body’s intricate systems. Pashanabhedadi Kwatha, a revered polyherbal formulation, exemplifies this Ayurvedic approach by combining a unique blend of herbs (such as Pashanabheda, Yastimadhu, Vasa, Gokshura, Eranda, Aragwadha phala majja, Pippali, Ela, Shilajit, Souvarchala lavana, and Mishri), each chosen for its specific role in supporting kidney health, also known for their diuretic, anti-inflammatory, and detoxifying properties. When combined, they work synergistically to enhance renal function, regulate fluid balance, and reduce inflammation, which are crucial factors in managing CKD. In Ayurveda, kidney dysfunction is often attributed to imbalances in the doshas, accumulation of ama and disturbances in agni and srotas. Pashanabhedadi Kwatha is formulated to address these imbalances, with its herbs targeting specific physiological processes that support renal and metabolic health. The present study aims to evaluate the effects of Pashanabhedadi Kwatha on CKD through the lens of Ayurvedic principles like Rasa Panchaka, and to explore its influence on doshic imbalances, ama, agni, srotas, and the specific phytochemical constituents responsible for its therapeutic benefits. By reviewing both classical and modern literature, this study seeks to shed light on the potential mechanisms behind its beneficial effects in CKD and offer insights into its clinical applications. KEYWORD :Ayurveda, Chronic Kidney Disease, Pashanabhedadi Kwatha, Rasa Panchaka.

African Animal Trypanosomiasis constitutes one of the greatest threats to the health of animals and socioeconomic status of people, particularly in developing countries. Chemotherapy, the main means of controlling the disease is limited due to parasite resistance and toxicity of the current anti-trypanosomal drugs. The development of a vaccine has been thwarted by antigenic variation of the parasite. Thus, plant extracts are one of the strategies being explored to address some of the problems encountered. The main objective of the current study was to investigate the toxicity and anti-trypanosomal activity of methanol and aqueous extracts of Acacia nilotica through in vivo assays against Trypanosoma brucei brucei. The chosen plants' healthy, fresh, matured leaves were air dried under shade, pulverized with mortar and pestle into powder, and passed through a 0.5mm mesh to standardize their particles. The plant samples were extracted using aqueous, methanol solvents. Qualitative and quantitative phytochemical analysis of the active chemical constituents of the extracts was conducted to determine saponins, flavonoids, tannins, terpenoids, steroids, and cardiac glycosides according to standard procedure. It was established that aqueous and methanol leaf extracts of the selected plants were safe in rats at dose levels of 1000, 3000, and 5000 mg/kg body weight for 72 hours. However, Sedation and abnormal movement were observed for both A. nilotica and Z. mucronata as manifestations of clinical toxicity at 5000mg/kg body weight. The fatal dose of all extracts exceeds the maximum dose of 5000mg/kg. Prolonged oral administration of the extracts for 21 days with A. nilotica extracts did not reveal major changes in body and organs weights, liver and kidney functions, the biochemical analysis showed a slight, non-significant increase in Alanine transaminase, Aspatate transaminase, and Alkaline phosphatase at (4000mg/kg) in rats, the average creatinine and urea levels were within the normal range, the relative organ weight and isolated organ are within the normal reference value. The photomicrographs of the liver and kidney sections showed mild histological changes. The in vivo assay showed the aqueous and methanol extracts from A. nilotica at 200mg/kg, 100mg/kg, and positive control (diminazine aceturate 3.5mg) reduced parasitaemia (p < 0.05), improved anaemia (p < 0.05), prevented body weight loss (p < 0.05) compared to the negative control. This study showed that the leaf of A. nilotica is safe and possess antitrypanosomal properties, suggesting that they may be a source of novel drugs for treatment of tropical diseases caused by trypanosomes. KEYWORD :Acacia nilotica, Trypanosomiasis, Toxicity, Histopathology, Trypanasoma brucie brucei

Introduction: Indralupta is one among the shiro kapalagata roga. According to Acharya Vagbhatta, pitta along with vata invades the romakoopa causes hairfall. Vitiation of Sleshma along with shonita obstructs the channels of Romakoopa leading to the stoppage of regrowth of hair1. This condition is known as Indralupta. Indralupta can be correlated with Alopecia areata in which there is a sudden hairfall that strarts with one or more circular bald patches. In Ayurveda both shodhana and shamana treatments are prescribed for Indralupta. This is a case report of 25 year old male patient complaints of patchy hair loss and thinning of hair since 2 months. Materials and Methods: The subject who approached Shalakya tantra opd of SDM Ayurveda hospital Udupi with symptoms of patchy hair loss and thinning of hair since 2 months was systematically reviewed and treatment modalities like pracchana and internally Arogyavardhini rasa, Tiktaka kashaya, Saptamruta loha and Bhargava prokta rasayana is advised. Results: The subject showed marked improvement symptomatically. Discussion: Ayurveda has great approach in curing the Indralupta. Nidana parivarjana, shamanoushadis and external applications are the main treatment modalities which can be concluded from this case report. KEYWORD :Indralupta, Alopecia areata, Pracchana