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Integrated Phytochemical Screening and Quantitative Antioxidant Evaluation (FRAP) of Garcinia Mangostana Pericarp Extracts: Unveiling Bioactive Constituents and Their Reducing Potential

Published:06 Jan 2026
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Naeem Hasan Khan1*, Nabila Perveen2, Nabil Haziq bin Khairun Nizam3, Mohd Hilman Jazli3

1 Pharmacology, Toxicology and Basic Health Sciences [PTBHS] Unit, Faculty of Pharmacy, AIMST University, Malaysia

2 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, AIMST University, Malaysia

3 Faculty of Pharmacy, AIMST University, Malaysia

Corresponding Author:Naeem Hasan Khan

picture_as_pdfDownload link10.47191/ijahm/v16i1.04

subjectAbstract

Introduction

Garcinia mangostana or mangosteen was traditionally used to treat various ailments especially gastrointestinal issues. This suggests the plant material contain high number of phytochemicals and potential natural antioxidant source. Garcinia mangostana, commonly known as mangosteen, is a tropical evergreen tree belonging to the family Clusiaceae, Angiosperms (Flowering Seed Plants) (dicotyledon), Autotrophic in nature with a hight of 25 meter. The fruit is best eaten fresh, because processing tends to ruin the flavour. It is sometimes eaten with sherbet or ice cream. Some Chinese like to eat the fruits, because they believe mangosteen has a cooling effect. Xanthones, including α-mangostin and γ-mangostin, have been extensively studied for their biological activity which includes anti-inflammatory, antimicrobial, and anticancer effects. Objectives: The research aimed to investigate the phytochemicals existing in the pericarp of G. mangostana and to evaluate its antioxidant activity. Methodology: Phytochemical screening was done including qualitative test for alkaloid, flavonoids, saponin and tannin. Characterization of the functional groups existing in plant extract was found using FT-IR spectral analysis. Ferric Reducing Antioxidant Power (FRAP) assay was used to evaluate its antioxidant capacity. This low-cost, basic, dependable approach produces consistent outcomes even without specific gear. Significantly, the FRAP test measures the overall reduction capability of antioxidants, so providing a more complete view of antioxidant capacity than methods as DPPH and ABTS that concentrate on particular radical scavenging. Its biologically relevance also arises from its capacity to replicate deteriorating conditions in biological systems, thereby enabling a more accurate portrayal of the antioxidant activity of in-vivo. These properties characterize FRAP as the recommended technique for thorough and consistent assessment of antioxidants. Result and

Conclusion

Majority of the constituents are alkaloid, flavonoid, saponin and tannin were confirmed. FTIR analysis revealed presence of hydroxyl, aromatic, aliphatic, and carbonyl-related functional groups. The antioxidant capacity was measured as 1.09 g AAE per gram of the extract. G. mangostana pericarp was confirmed to be a rich source of phytochemicals and antioxidants.

sellKeywords

Garcinia mangostanaantioxidant activityFRAP assayantioxidantplant extractphytochemicalsmangosteen pericarp

format_list_numberedReferences

  1. Adenina, S., Louisa, M., Soetikno, V., Arozal, W., & Wanandi, S. (2020). The effect of alpha mangostin on epithelial-mesenchymal transition on human hepatocellular carcinoma hepg2 cells surviving sorafenib via tgf-β/smad pathways. Advanced Pharmaceutical Bulletin, 10(4), 648-655. https://doi.org/10.34172/apb.2020.078
  2. Aizat, W., Jamil, I., Ahmad-Hashim, F., & Noor, N. (2019). Recent updates on metabolite composition and medicinal benefits of mangosteen plant. Peerj, 7, e6324. https://doi.org/10.7717/peerj.6324
  3. Al-Massarani, S., Gamal, A., Al-Musayeib, N., Mothana, R., Basudan, O., Al‐Rehaily, A., … & Maes, L. (2013). Phytochemical, antimicrobial and antiprotozoal evaluation of Garcinia mangostana pericarp and α-mangostin, its major xanthone derivative. Molecules, 18(9), 10599-10608. https://doi.org/10.3390/molecules180910599
  4. Azam, M., Eden, W., Fibriana, A., & Rahayu, S. (2021). Antioxidant properties of capsule dosage form from mixed extracts of Garcinia mangostana rind and solanum lycopersicum fruit. Acta Pharmaceutica Sciencia, 59(1), 603. https://doi.org/10.23893/1307-2080.aps.05904
  5. Balunas, M., Su, B., Brueggemeier, R., & Kinghorn, A. (2008). Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity. Journal of Natural Products, 71(7), 1161-1166. https://doi.org/10.1021/np8000255
  6. Chang, H. and Yang, L. (2012). Gamma-mangostin, a micronutrient of mangosteen fruit, induces apoptosis in human colon cancer cells. Molecules, 17(7), 8010-8021. https://doi.org/10.3390/molecules17078010
  7. Chen, C., Hsieh, S., Lin, C., Lin, Y., Tsai, J., & Hsieh, Y. (2017). Alpha-mangostin suppresses the metastasis of human renal carcinoma cells by targeting mek/erk expression and mmp-9 transcription activity. Cellular Physiology and Biochemistry, 44(4), 1460-1470. https://doi.org/10.1159/000485582
  8. Chew, Y. and Lim, Y. (2018). Evaluation and comparison of antioxidant activity of leaves, pericarps and pulps of three garcinia species in malaysia yik-ling chew, and yau-yan lim. Free Radicals and Antioxidants, 8(2), 130-134. https://doi.org/10.5530/fra.2018.2.19
  9. Ching, M., Chinnappan, S., & Rajagopal, M. (2019). In vitro anti-motility and antispasmodic effects of Garcinia mangostana extracts in isolated chicken ileum preparation. International Journal of Research in Pharmaceutical Sciences, 10(2), 1444-1447. https://doi.org/10.26452/ijrps.v10i2.714
  10. Chitra, V., Sukumaran, E., Sivasubramanian, L., & Vetrivelan, V. (2017). A comparative study of actinidia deliciosa and Garcinia mangostana in ovariectomy-induced osteoporosis in female wistar rats. Biomed Research International, 2017, 1-10. https://doi.org/10.1155/2017/5349520
  11. Chooruk, A., Piwat, S., & Teanpaisan, R. (2017). Antioxidant activity of various oral lactobacillus
  12. strains. Journal of Applied Microbiology, 123(1), 271-279. https://doi.org/10.1111/jam.13482
  13. Damgaard, T., Otte, J., Meinert, L., Jensen, K., & Lametsch, R. (2014). Antioxidant capacity of hydrolyzed porcine tissues. Food Science & Nutrition, 2(3), 282-288. https://doi.org/10.1002/fsn3.106
  14. Fan, W. (2024). Effect of tea polyphenols as an antioxidant on pork for frying at different temperatures and times. Food Science & Nutrition, 12(3), 2029-2036. https://doi.org/10.1002/fsn3.3901
  15. Fernando, A., Attanayake, A., & Jayatilaka, K. (2019). Screening of selected sri lankan seasonal fruit extracts for total antioxidant activity in vitro. Asian Journal of Pharmaceutical Research and Development, 7(1), 7-12. https://doi.org/10.22270/ajprd.v7i1.459
  16. Fu, Y., Zhou, H., Wang, M., Cen, J., & Wang, Q. (2014). Immune regulation and anti-inflammatory effects of isogarcinol extracted from Garcinia mangostana l. against collagen-induced arthritis. Journal of Agricultural and Food Chemistry, 62(18), 4127-4134. https://doi.org/10.1021/jf405790q
  17. Goñi, I. and Hernández-Galiot, A. (2019). Intake of nutrient and non-nutrient dietary antioxidants. contribution of macromolecular antioxidant polyphenols in an elderly mediterranean population. Nutrients, 11(9), 2165. https://doi.org/10.3390/nu11092165
  18. Gupta, D., Bhardwaj, R., & Gupta, R. (2011). <i>in vitro</i> antioxidant activity of extracts from the leaves of <i>abies pindrow</i> royle. African Journal of Traditional Complementary and Alternative Medicines, 8(4). https://doi.org/10.4314/ajtcam.v8i4.8
  19. Gutiérrez-Orozco, F. and Failla, M. (2013). Biological activities and bioavailability of mangosteen xanthones: a critical review of the current evidence. Nutrients, 5(8), 3163-3183. https://doi.org/10.3390/nu5083163
  20. Haminiuk, C., Plata-Oviedo, M., Guedes, A., Stafussa, A., Bona, E., & Carpes, S. (2011). Chemical, antioxidant and antibacterial study of brazilian fruits. International Journal of Food Science & Technology, 46(7), 1529-1537. https://doi.org/10.1111/j.1365-2621.2011.02653.x
  21. He, W., Ye, H., Li, H., & Gao, Q. (2023). Alpha mangostin ameliorates gestational diabetes in rats via alteration of oxidative stress and inflammation reaction. International Journal of Pharmacology, 19(1), 1-13. https://doi.org/10.3923/ijp.2023.1.13
  22. Hosu, A., Cimpoiu, C., David, L., & Moldovan, B. (2016). Study of the antioxidant property variation of cornelian cherry fruits during storage using hptlc and spectrophotometric assays. Journal of Analytical Methods in Chemistry, 2016, 1-5. https://doi.org/10.1155/2016/2345375
  23. Huang, W., Liang, Y., & Ma, X. (2019). Alpha-mangostin induces endoplasmic reticulum stress and autophagy which count against fatty acid synthase inhibition mediated apoptosis in human breast cancer cells. Cancer Cell International, 19(1). https://doi.org/10.1186/s12935-019-0869-z
  24. Husen, S., Ansori, A., Susilo, R., Hayaza, S., & Winarni, D. (2018). The effect of alpha-mangostin in glucose level, cholesterol level, and diameter of the islets of langerhans of stz-induced diabetic mice. https://doi.org/10.5220/0007547005610566
  25. Ibrahim, U., Austin, E., & Salleh, R. (2015). Effect of drying temperature and time on antioxidant and total phenolic content in Garcinia mangostana pericarp. Advanced Materials Research, 1113, 279-284. https://doi.org/10.4028/www.scientific.net/amr.1113.279
  26. Ibrahim, U., Salleh, R., Suzihaque, M., & Hashib, S. (2015). Effect of radiation heat on the chemical and physical properties of bread enhanced with Garcinia mangostana pericarp powder. Procedia - Social and Behavioral Sciences, 195, 2652-2659. https://doi.org/10.1016/j.sbspro.2015.06.470
  27. Issaad, F., Fernandes, I., Enache, T., Mouats, C., Rodrigues, I., & Oliveira-Brett, A. (2016). Flavonoids in selected mediterranean fruits: extraction, electrochemical detection and total antioxidant capacity evaluation. Electroanalysis, 29(2), 358-366. https://doi.org/10.1002/elan.201600370
  28. Jariyapongskul, A., Areebambud, C., Suksamrarn, S., & Mekseepralard, C. (2015). Alpha-mangostin attenuation of hyperglycemia-induced ocular hypoperfusion and blood retinal barrier leakage in the early stage of type 2 diabetes rats. Biomed Research International, 2015, 1-10. https://doi.org/10.1155/2015/785826
  29. Jiang, M., Huang, S., Liu, Q., & Lei, M. (2021). Alpha‐mangostin improves endothelial dysfunction in db/db mice through inhibition of asmase/ceramide pathway. Journal of Cellular and Molecular Medicine, 25(7), 3601-3609. https://doi.org/10.1111/jcmm.16456
  30. Johnson, J., Petiwala, S., Syed, D., Rasmussen, J., Adhami, V., Siddiqui, I., … & Mukhtar, H. (2011). -mangostin, a xanthone from mangosteen fruit, promotes cell cycle arrest in prostate cancer and decreases xenograft tumor growth. Carcinogenesis, 33(2), 413-419. https://doi.org/10.1093/carcin/bgr291
  31. Karim, N. and Tangpong, J. (2018). Biological properties in relation to health promotion effects of Garcinia mangostana (queen of fruit). Journal of Health Research, 32(5), 364-370. https://doi.org/10.1108/jhr-08-2018-043
  32. Kharisma, V. (2024). Bioinformatics study of selective inhibitor from Garcinia mangostana l. tackle hiv‑1 infection. Food Systems, 6(4), 471-476. https://doi.org/10.21323/2618-9771-2023-6-4-471-476
  33. Kim, S., Han, J., Le, T., Sohng, J., & Jung, H. (2020). Anticancer and antiangiogenic activities of novel α-mangostin glycosides in human hepatocellular carcinoma cells via downregulation of c-met and hif-1α. International Journal of Molecular Sciences, 21(11), 4043. https://doi.org/10.3390/ijms21114043
  34. Kurose, H., Shibata, M., Iinuma, M., & Otsuki, Y. (2012). Alterations in cell cycle and induction of apoptotic cell death in breast cancer cells treated withα-mangostin extracted from mangosteen pericarp. Journal of Biomedicine and Biotechnology, 2012, 1-9. https://doi.org/10.1155/2012/672428
  35. Kuswahyuning, R., Sulaiman, T., Ananingrum, G., & Andini, R. (2020). The influence of propylene glycol/water and ethanol/water binary solvents on the in vitro permeation of Garcinia mangostana l. pericarp extract across shed snakeskin. Indonesian Journal of Pharmacy, 187. https://doi.org/10.22146/ijp.599
  36. Lalfakzuala, R. (2021). Antibacterial activity and phytochemical screening of garcinia pedunculata roxb. ex buch. - ham. fruit extract by hplc–esi-ms. Journal of Pure and Applied Microbiology, 15(4), 2183-2194. https://doi.org/10.22207/jpam.15.4.42
  37. Larasati, F., Batubara, I., & Lestari, Y. (2020). The presence of endophytic actinobacteria in mangosteen peel (Garcinia mangostana) and its antioxidant activity. Biodiversitas Journal of Biological Diversity, 21(4). https://doi.org/10.13057/biodiv/d210429
  38. Le, M., Lanaspa, M., Cicerchi, C., Rana, J., Scholten, J., Hunter, B., … & Rj, J. (2015). Bioactivity-guided identification of botanical inhibitors of ketohexokinase. Planta Medica, 81(11). https://doi.org/10.1055/s-0035-1556298
  39. Lee, C., Ying, T., Chiou, H., Hsieh, S., Wen, S., Chou, R., … & Hsieh, Y. (2017). Alpha-mangostin induces apoptosis through activation of reactive oxygen species and ask1/p38 signaling pathway in cervical cancer cells. Oncotarget, 8(29), 47425-47439. https://doi.org/10.18632/oncotarget.17659
  40. Lestari, N., Louisa, M., Soetikno, V., Suwana, A., Ramadhan, P., Akmal, T., … & Arozal, W. (2018). Alpha mangostin inhibits the proliferation and activation of acetaldehyde induced hepatic stellate cells through tgf-β and erk 1/2 pathways. Journal of Toxicology, 2018, 1-9. https://doi.org/10.1155/2018/5360496
  41. LewisOscar, F., Mishra, B., Khader, R., Ganesan, N., & Mylonakis, E. (2022). In vitro and in vivo bactericidal and antibiofilm efficacy of alpha mangostin against staphylococcus aureus persister cells. Frontiers in Cellular and Infection Microbiology, 12. https://doi.org/10.3389/fcimb.2022.898794
  42. Li, G., Thomas, S., & Johnson, J. (2013). Polyphenols from the mangosteen (Garcinia mangostana) fruit for breast and prostate cancer. Frontiers in Pharmacology, 4. https://doi.org/10.3389/fphar.2013.00080
  43. Li, P., Tian, W., & Ma, X. (2014). Alpha-mangostin inhibits intracellular fatty acid synthase and induces apoptosis in breast cancer cells. Molecular Cancer, 13(1). https://doi.org/10.1186/1476-4598-13-138
  44. Li, W. (2015). Profile of dna damage protective effect and antioxidant activity of different solvent extracts from the pericarp of Garcinia mangostana. Journal of Food and Nutrition Sciences, 3(1), 1. https://doi.org/10.11648/j.jfns.s.2015030101.11
  45. Lin, F., Kennelly, E., Linington, R., & Long, C. (2023). Comprehensive metabolite profiling of two edible garcinia species based on uplc-esi-qtof-mse coupled with bioactivity assays. Journal of Agricultural and Food Chemistry, 71(19), 7604-7617. https://doi.org/10.1021/acs.jafc.2c08372
  46. Lucas, A., Bosetti, C., Boffetta, P., Negri, E., Tavani, A., Serafini, M., … & Rossi, M. (2016). Dietary total antioxidant capacity and pancreatic cancer risk: an italian case–control study. British Journal of Cancer, 115(1), 102-107. https://doi.org/10.1038/bjc.2016.114
  47. Martı́nez, A., Hernández-Marín, E., & Galano, A. (2012). Xanthones as antioxidants: a theoretical study on the thermodynamics and kinetics of the single electron transfer mechanism. Food & Function, 3(4), 442. https://doi.org/10.1039/c2fo10229c
  48. Mishra, S. (2016). Modulation of digestive enzymes and lipoprotein metabolism by alpha mangosteen extracted from mangosteen (Garcinia mangostana) fruit peels. Journal of Microbiology Biotechnology and Food Sciences, 6(1), 717-721. https://doi.org/10.15414/jmbfs.2016.6.1.717-721
  49. Mohamed, G., Ibrahim, S., Shaaban, M., & Ross, S. (2014). Mangostanaxanthones i and ii, new xanthones from the pericarp of Garcinia mangostana. Fitoterapia, 98, 215-221. https://doi.org/10.1016/j.fitote.2014.08.014
  50. Márquez-Valadez, B., Maldonado, P., Galván-Arzate, S., Méndez-Cuesta, L., Cruz, V., Pedraza-Chaverri, J., … & Santamaría, A. (2012). Alpha-mangostin induces changes in glutathione levels associated with glutathione peroxidase activity in rat brain synaptosomes. Nutritional Neuroscience, 15(5), 13-19. https://doi.org/10.1179/147683012x13327575416400
  51. Nufiarwan, F. and Wulandari, L. (2019). The effect of mangosteen (Garcinia mangostana) pericarp extract on retinoblastoma cell culture proliferation. International Journal of Retina, 2(1). https://doi.org/10.35479/ijretina.2019.vol002.iss001.59
  52. Payne, A., Mazzer, A., Clarkson, G., & Taylor, G. (2013). Antioxidant assays – consistent findings from frap and orac reveal a negative impact of organic cultivation on antioxidant potential in spinach but not watercress or rocket leaves. Food Science & Nutrition, 1(6), 439-444. https://doi.org/10.1002/fsn3.71
  53. Phitaktim, S., Chomnawang, M., Sirichaiwetchakoon, K., Dunkhunthod, B., Hobbs, G., & Eumkeb, G. (2016). Synergism and the mechanism of action of the combination of α-mangostin isolated from Garcinia mangostana l. and oxacillin against an oxacillin-resistant staphylococcus saprophyticus. BMC Microbiology, 16(1). https://doi.org/10.1186/s12866-016-0814-4
  54. Phumlek, K., Itharat, A., Pongcharoen, P., Chakkavittumrong, P., Lee, H., Moon, G., … & Davies, N. (2022). Garcinia mangostana hydrogel patch. Research in Pharmaceutical Sciences, 17(5), 457-467. https://doi.org/10.4103/1735-5362.355195
  55. Priya, V., Jainu, M., & Surapaneni, K. (2018). Biochemical evidence for the antitumor potential of Garcinia mangostana linn. on diethylnitrosamine-induced hepatic carcinoma. Pharmacognosy Magazine, 14(54), 186. https://doi.org/10.4103/pm.pm_213_17
  56. Qian, D., Florenly, F., Liena, L., & Purba, D. (2021). Effectiveness of ethanol extract mangosteen peel (Garcinia mangostana l.) in accelerating post-tooth extraction healing in wistar rats. Budapest International Research in Exact Sciences (Birex) Journal, 4(1), 22-30. https://doi.org/10.33258/birex.v4i1.3473
  57. Rahmaniah, R., Yuyuntia, Y., Soetikno, V., Arozal, W., Antarianto, R., & Louisa, M. (2017). Alpha mangostin inhibits hepatic stellate cells activation through tgf-β/smad and akt signaling pathways: an in vitro study in lx2. Drug Research, 68(03), 153-158. https://doi.org/10.1055/s-0043-119074
  58. Ratwita, W., Sukandar, E., Adnyana, I., & Kurniati, N. (2019). Alpha mangostin and xanthone activity on fasting blood glucose, insulin and langerhans islet of langerhans in alloxan induced diabetic mice. Pharmacognosy Journal, 11(1), 64-68. https://doi.org/10.5530/pj.2019.1.12
  59. Razavi, B. and Hosseinzadeh, H. (2020). Investigating the ameliorative effect of alpha‐mangostin on development and existing pain in a rat model of neuropathic pain. Phytotherapy Research, 34(12), 3211-3225. https://doi.org/10.1002/ptr.6768
  60. Ruankham, W., Suwanjang, W., Phopin, K., Songtawee, N., Prachayasittikul, V., & Prachayasittikul, S. (2022). Modulatory effects of alpha-mangostin mediated by sirt1/3-foxo3a pathway in oxidative stress-induced neuronal cells. Frontiers in Nutrition, 8. https://doi.org/10.3389/fnut.2021.714463
  61. S, K. and Kalava, S. (2021). A study on in vitro antioxidant activity of aqueous seed extract of sesbania sesban (l) merr.. Kongunadu Research Journal, 8(2), 69-74. https://doi.org/10.26524/krj.2021.21
  62. Shibata, M., Iinuma, M., Morimoto, J., Kurose, H., Akamatsu, K., Okuno, Y., … & Otsuki, Y. (2011). Α-mangostin extracted from the pericarp of the mangosteen (Garcinia mangostanalinn) reduces tumor growth and lymph node metastasis in an immunocompetent xenograft model of metastatic mammary cancer carrying a p53 mutation. BMC Medicine, 9(1). https://doi.org/10.1186/1741-7015-9-69
  63. Sultan, O., Kantilal, H., Khoo, S., Davamani, F., Eusufzai, S., Rashid, F., … & Alam, M. (2022). The potential of α-mangostin from Garcinia mangostana as an effective antimicrobial agent—a systematic review and meta-analysis. Antibiotics, 11(6), 717. https://doi.org/10.3390/antibiotics11060717
  64. Syam, S., Bustamam, A., Abdullah, R., Sukari, M., Hashim, N., Mohan, S., … & Abdelwahab, S. (2014). Β mangostin suppress lps-induced inflammatory response in raw 264.7 macrophages in vitro and carrageenan-induced peritonitis in vivo. Journal of Ethnopharmacology, 153(2), 435-445. https://doi.org/10.1016/j.jep.2014.02.051
  65. Tan, S., Tan, S., & Tan, C. (2020). Antioxidant, hypoglycemic and anti-hypertensive properties of extracts derived from peel, fruit and kernel of salak. British Food Journal, 122(10), 3029-3038. https://doi.org/10.1108/bfj-03-2020-0233
  66. Tareq, F., Yıldız, E., & Luthria, D. (2022). Oxidative stress and antioxidants—a critical review on in vitro antioxidant assays. Antioxidants, 11(12), 2388. https://doi.org/10.3390/antiox11122388
  67. Wang, M., Xie, Y., Zhong, Y., Cen, J., Wang, L., Liu, Y., … & Wang, Q. (2016). Amelioration of experimental autoimmune encephalomyelitis by isogarcinol extracted from Garcinia mangostana l. mangosteen. Journal of Agricultural and Food Chemistry, 64(47), 9012-9021. https://doi.org/10.1021/acs.jafc.6b04145
  68. Wang, W. (2023). Dietary overall antioxidant intake associates with all-cause and cause-specific mortality among adults with depression: result from the national health and nutrition examination survey (2005-2018).. https://doi.org/10.21203/rs.3.rs-3342036/v1
  69. Xu, Q., Ma, J., Liu, J., Duan, W., Sheng, L., Chen, X., … & Li, X. (2014). α-mangostin suppresses the viability and epithelial-mesenchymal transition of pancreatic cancer cells by downregulating the pi3k/akt pathway. Biomed Research International, 2014, 1-12. https://doi.org/10.1155/2014/546353
  70. Yang, M., Chung, S., Chung, C., Kim, D., Song, W., Koo, S., … & Chun, O. (2011). Estimation of total antioxidant capacity from diet and supplements in us adults. British Journal of Nutrition, 106(2), 254-263. https://doi.org/10.1017/s0007114511000109
  71. Yoshimura, M., Ninomiya, K., Tagashira, Y., Maejima, K., Yoshida, T., & Amakura, Y. (2015). Polyphenolic constituents of the pericarp of mangosteen (Garcinia mangostana l.). Journal of Agricultural and Food Chemistry, 63(35), 7670-7674. https://doi.org/10.1021/acs.jafc.5b01771
  72. Yuan, J., Wu, Y., & Lu, G. (2013). Α-mangostin suppresses lipopolysaccharide-induced invasion by inhibiting matrix metalloproteinase-2/9 and increasing e-cadherin expression through extracellular signal-regulated kinase signaling in pancreatic cancer cells. Oncology Letters, 5(6), 1958-1964. https://doi.org/10.3892/ol.2013.1290
  73. Zamarudin, Z. (2023). Mangosteen (Garcinia mangostana): extraction, purification, bioactivities and toxicities. Halalsphere, 3(2), 13-27. https://doi.org/10.31436/hs.v3i2.74
  74. Zhong, G., Pu, J., Wu, Y., Yi, Z., Wan, L., Wang, K., … & Gong, J. (2020). Total antioxidant capacity and pancreatic cancer incidence and mortality in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer Epidemiology Biomarkers & Prevention, 29(5), 1019-1028. https://doi.org/10.1158/1055-9965.epi-19-1511
  75. Anastasia W. I., Vita T.R., Cici. D., & Wuri. A., (2021) Antibacterial activity of Garcinia mangostana peel-dyed cotton fabrics using synthetic and natural mordants. https://doi.org/10.1016/j.scp.2021.100440
  76. Ashraf A. M et al. Ashraf A. M., Abdulaziz A. A., Khalid S.A., Turki M. D., Essam N. S., and Marwah M. B. Antimicrobial activity of some plant extracts against bacterial strains causing food poisoning diseases, Saudi J. Biol. Sci. (2018)
  77. Sienna K. F., Sophia N. S., Romeliza S., Dulce M. N., Anthony I. P (2024) Antibacterial Properties of Garcinia mangostana Linn. Ethanolic and Methanolic Extracts Against Selected Gram-Positive and Gram-Negative Bacteria: A Meta-Analysis, Malaysian Journal

How to Cite

Khan, N. H., Perveen, N., Nizam, N. H. b. K., & Jazli, M. H. (2026). Integrated Phytochemical Screening and Quantitative Antioxidant Evaluation (FRAP) of Garcinia Mangostana Pericarp Extracts: Unveiling Bioactive Constituents and Their Reducing Potential. International Journal of Ayurvedic and Herbal Medicine, 16(1). https://doi.org/10.47191/ijahm/v16i1.04

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