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Preclinical Evaluation Of Polyherbal Formulations: Hypoglycemic Activity In Rats.

Published:02 Mar 2012
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Padmanabha Rao Amarachinta1*, Kaiser Jamil2

1 Lalitha College of Pharmacy, Ghatkesar, Hyderabad- 501 301, India.

2 School of Biotechnology, (MGNIRSA), University of Mysore, India.

Corresponding Author:Padmanabha Rao Amarachinta

picture_as_pdfDownload link10.47191/ijahm/v2i2.01

subjectAbstract

Diabetes mellitus is a metabolic disorder and the disease management is an important measure for the pharmacotherapy. The medicinal plants play very vital role in preventing the advancement of the disease. The polyherbal extract was prepared from Eugenia Jambolana-seed and Cinnamomum zeylenicum-bark as hydro alcohol and aqueous extracts. The extracts were screened for invitro antidiabetic activity. Among all screened extracts the polyherbal extract APKJ-004 showed prominent invitro antidiabetic activity. The present study was designed for assessment of toxicity and therapeutic efficacy of the selected polyherbal extract APKJ-004. The acute and sub acute toxicity were conducted in wistar rats. The results of toxicity assessment revealed that clinical, biochemical and Histopathological parameters studied were in normal range and comparable to controls. The study revealed that no toxic symptoms observed throughout the period of exposure. The invivo evaluation results showed that the extract APKJ-004 reduced the elevated glucose levels (97.01± 6.23mg/dl) were comparable to the glibenclamide (89.3± 7.42mg/dl). The insulin levels were considerably increased in polyherbal treated group from 06.75 ± 0.96 μU/ml to 23.13±0.35μU/ml. The glucose tolerance test results revealed the absorption efficiency of APKJ 004 was found to be 112.3± 6.68 mg/dl when compared with standard glibenclamide (93.4±4.67mg/dl) treated group at 120 min. Based on the above facts it is concluded that APKJ-004 polyherbal extract act as a potent antidiabetic agent with minimal or no side effects and useful in the pharmacotherapy of diabetes.

sellKeywords

Hypoglycemic Activitypolyherbal extractDiabetes MellitusStreptozotocin Preclinical toxicity

format_list_numberedReferences

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How to Cite

Amarachinta, P. R. & Jamil, K. (2012). Preclinical Evaluation Of Polyherbal Formulations: Hypoglycemic Activity In Rats.. International Journal of Ayurvedic and Herbal Medicine, 2(2). https://doi.org/10.47191/ijahm/v2i2.01

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