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International Journal ofAyurvedic and Herbal Medicine
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Antidiabetic Activity Of Enicostemma Littorale (Mamajjaka) Leaf Extracts In Streptozotocin-Induced Diabetic Rats

Published:30 May 2012
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Dr. Amit R. Nampalliwar1*, Dr. Pawankumar Godatwar1

1 P.G.Department of Roganidan & Vikriti Vijnana, National Institute of Ayurveda, Jaipur-302002(Raj.), India.

Corresponding Author:Dr. Amit R. Nampalliwar

picture_as_pdfDownload link10.47191/ijahm/v2i3.16

subjectAbstract

The antidiabetic activity of Enicostemma littorale (Mamajjaka) leaf extracts was investigated in Streptozotocin-induced diabetic albino rats. A comparison was made between the action of different extracts of Enicostemma littorale (Mamajjaka) and known antidiabetic drug glibenclamide (600 µg/kg b. wt.). An oral glucose tolerance test (OGTT) was also performed in experimental diabetic rats. The petroleum ether, chloroform, alcohol and aqueous extract of E. littorale were obtained by simple maceration method and were subjected to standardization using pharmacognostical and phytochemical screening methods. Dose selection was made on the basis of acute oral toxicity study (50-5000 mg/kg b.wt.) as per OECD guidelines. E. littorale aqueous extract (ELAE) and ethonolic extract (ELEE) showed significant antidiabetic activity. In Streptozotocin -induced model, blood glucose levels of these extracts on 7th day of the study were 132.00±4.955_mg/dl (ELAE) and 163.3±28.69 mg/dl (ELEE) in comparison of chloroform extract (210.8±14.91 mg/dl). In glucose loaded rats, ELAE exhibited glucose level of 176±3.724 mg/dl after 30 min. and 110.33±6.687 mg/dl after 90 min, whereas the levels in ELEE treated animals were 166.66±3.403 mg/dl after 30 min. and 148.83±4.615 mg/dl after 90 min. These extract also prevented body weight loss in diabetic rats. The drug has the potential to act as an antidiabetic drug.

sellKeywords

Antidiabetic activityacute toxicityInj. StreptozotocinEnicostemma littoraleMamajjaka

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  1. Apparao C., Kameswararao B., Kesavulu MM., Evaluation of antidiabetic effect of momordica cymbalaria fruit in alloxan-diabetic rats. Fitoterapia 2003; 74:7-13.
  2. Saikat Neogi, Hindustan times, New Delhi, Sept. 03-2007- www.hindustantimes.com
  3. Satyanarayana T, Katyayani BM, Hemalatha E, Anjana AM, Chinna EM. Hypoglycemic and antihyperglycemic effect of alcoholic extract of Euphorbia leucophylla and its fractions in normal and in alloxan induced diabetic rats, Pharmacogn Mag 2006; 2: 244-53.
  4. Shirwaikar A, Rajendran K, Punitha IS. Antidiabetic activity of alcoholic stem extract of Coscinium fenestratum in streptozotocin-nicotinamide induced type 2 diabetes rats. J Ethnopharmacol 2005;97:369-74.
  5. Marro J, Vasu VT, Gupta S. Dose dependent hypoglycemic effect of aqueous extract of Enicostemma littorale Blume in alloxan induced diabetic rats. Phytomedicine 2003;10:196-9.
  6. Chhetri DR,. Parajuli P, Subba GC, Antidiabetic plants used by Sikkim and Darjeeling Himalayan tribes, India. J Ehtnopharmacol 2005;99:199-202.
  7. Shankar PK, Kumar Vasanth, Rao Namita. Evaluation of Antidiabetic Activity of Ginkgo Biloba in Streptozotocin Induced Diabetic rats. Iranian Journal of Pharmacology and Therapeutics 2005;4:16-9.
  8. Grover JK, Yadav SP. Pharmacological action and potential uses of Momordica charantia: A review.J Ethanopharmacol 2004;93:123-32
  9. Shirwaikar A, Rajendran K, Barik R. Effect of aqueous bark extract of Garuga pinnata Roxb. In streptozotocin -nicotinamide induced type-II diabetes mellitus. J Ethnopharmacol 2006;107:285-90.
  10. Manoharan S., Punitha R. Antihyperglycemic and antilipidperoxidative effects of Pongamia pinnata (Linn.) Pierre flowers in alloxan induced diabetic rats. J Ethnopharmacol 2006;105:39-46.
  11. Dr. Amrit Pal Singh, Enicostemma littorale Blume- Scientific Monograph_article on- opensiuc.lib.siu.edu/cgi/viewcontent.cgi?article
  12. Dr. PV Sharma, Dravyagunavijnana- vol.-II, Choukhamba Bharati Academy, Varanasi, Reprint: 1999, pp-704- 705.
  13. Hayashi K, Kojima R, Ito M (2006) strain differences in the diabetogenic activity of streptozotocin in mice. Biol Pharma. Bull 29:1110-1119.
  14. Higdon HL, Parnell PG, Hill, JE Spitzer JC (2001): Streptozotocin-induced pancreatic islet destruction in beef cows. Vet Pathol 38:715-720.
  15. Pharmacopoeia of India, Ministry of Health New Delhi: Government of India; 1982. P.948, 650.
  16. Khandelwal KR. Practical pharmacognosy. 14th Ed. Pune: Nirali prakashan; 2005. pp.146-57.
  17. OECD/OCDE, OECD Guidelines for the testing of chemicals, revised draft guidelines 423: Acute Oral toxicity- Acute toxic class method, revised document, CPCSEA, Ministry of Social Justice and Empowerment. New Delhi: Government of India; 2000.
  18. Sellamuthu PS, Muniappan BP, Perumal SM, Kandasamy M. Antihyperglycemic effect of Mangiferin in streptozotocin induced diabetic rats. J. Health Sci. 2009;55:206-14.
  19. Kannur DM, Hukkeri VI, Akki KS. Antidiabetic activity of Caesalpinia bonducella seed extracts in rats. Fitoterapia 2006; 77:546-9.
  20. Dr. Jasmin Attar. Dr. P.Suresh, To evaluate the efficacy of prepared Rasaka & Yashada Bhasma in experimental model, M.D.(Ayu.) thesis-2012, Dept. of R.S.&B.K., N.I.A., Jaipur, pp-163.
  21. Nagappa AN, Thakurdesai PA, Rao VN, Jiwan Singh. Antidiabetic activity of Terminalia catappa linn fruits. J. Ethanopharmacol 2003;88:45-50.
  22. Friedewald WT, Levy RI, Fredickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502.
  23. Sikarwar M.S., MB Patil. Antidiabetic activity of Pongamia pinnata leaf extracts in alloxan-induced diabetic rats. IJAR Vol-1, Oct-Dec 2010, pp.199-204.

How to Cite

Nampalliwar, D. A. R. & Godatwar, D. P. (2012). Antidiabetic Activity Of Enicostemma Littorale (Mamajjaka) Leaf Extracts In Streptozotocin-Induced Diabetic Rats. International Journal of Ayurvedic and Herbal Medicine, 2(3). https://doi.org/10.47191/ijahm/v2i3.16

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