Evaluation Of Analgesic And Anti-Inflammatory Activity Of Herbomineral Formulation Sandhivaataari Gutika

Analgesic and anti- inflammatory activity for herbomineral formulation was evaluated by using hot plate method. Crude extract of herbomineral formulation was prepared by using tween 80.2 % crude drugs which is present in the form of suspension was administered through oral route at a dose of 100 mg/kg, 200 mg/kg in mice weighing between 20-25 g using oral gavage and evaluated for analgesic activity at different time intervals such as 0, 15, 30, 60 and 90 minutes against standard (Tramadol Hydrochloride 22.8 mg/kg i.p) and control group, P< 0.05 was considered as significant. At a dose 100 mg/kg herbomineral formulation had shown significant activity10.00 ± 1.10 (P < 0.001), 200 mg/kg had shown significant activity at15, 30, 60 and 90 min time interval (P<0.001). REFERANCES Dr.Naaginidas Chaganlal Shaw, Rasavaidya, Bharatha Bhaishagya Ratnakara, Rasaprakarana, Volume:V, Edtn.2005, Hindi Version,Pp.304. Kokate C.K. Practical Pharmacognosy. Vallabh prakashan New Delhi. Preliminary phytochemical screening, chapter 6, pp106-111. Phytocemical screening and in-vitro anti-oxidant activity of herbomineral compound named Trushanadiloha. Int. J. Res.Phytoche. Pharmacol, 1(4), 2011, 224 - 228. Shailendra S.Gurav, Vijay D.Gulkari, Nandkishore J.Duragkar and Aarun T. Patil IJPT January 2008 7(1) P.No.21-24. Khandelwal K.R.Practical Pharmacognosy. Nirali Prakashan Pune. Techniques and Experiments, Chapter 40,17th ed. pp149-153. Sharma MC, Smita Sharma: Some Plant extracts used in pharmacologically activity of Anxiolytics, Antidepressant, Analgesic, and Anti-inflammatory activity. Digest Journal of Nanomaterials and Biostructures. March 2010; 5 (1): 223 - 227. 7. Franzotti EM, Santos CVF. Anti-inflammatory, analgesic activity and acute toxicity of Sida cordifolia(L). (Malva-branca). J. Ethnopharmacol. 2000; 72:273-278. 8. Eddy NB, Leimback D. Synthetic analgesic. II. Dithienyl butenyl and dithienyl butyl amines. J Pharmacol ExpTher 1953; 107: 385-393. 9. Elisabetsky E, Amador TA. Analgesic activity of psy- chotria colorata (Willd.ex R. and S.). Muell. Arg. Alka- loids. J Ethnopharmacol.1995; 48: 77-83. 10. Jayaprakash GK, Rao LJ. Phenolic constituents from lichen Parmontrema stuppeum. (Nyl.) hale and their antioxidant activity. 2000; 55:1018-1022. 11. Mustaffa F, Indurkar J. Analgesic activity, toxicity study and phytochemical screening of standardized Cinnomomum iners leaves methanolic extract2010;2(2): 76-81. 12. Pal S, Sen T, A.K. Chaudhuri AK. Neuropsychopharma- cological profile of the methanolic fraction of bryo- phyllum pinnatum leaf extract. J Pharm Pharmacol 1999;51: 313-18.) 13. Priyanka Vijay, Rekha Vijay vergia. Analgesic, anti- inflammatory and antipyretic activity of Cissus quad- rangularis. Journal of Pharmaceutical Science and Technology 2010; 2 (1):111-118 14. Raquibul Hasan SM, Mariam Jamila: Analgesic and An-tioxidant Activity of the Hydromethanolic Extract of Mikania scandens (L.) Willd. Leaves. American Jour-nal of Pharmacology and Toxicology 2009; 4 (1): 1-7. 15. Sharma MC, Smita Sharma. Some Plant extracts used in pharmacologically activity of Anxiolytics, Antidepres-sant, Analgesic, and Anti-inflammatory activity. Di-gest Journal of Nanomaterials and Biostructures ,2010; 5 (1): 223 - 227. 16. Yerima M, Magaji MG: Analgesic and Anti-inflammatory activities of the Methanolic leaves ex-tract of Securinega virosa (Euphorbiaceae). Nig Journ Pharm Sci 2009; 8 (1): 47 - 53.