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Volume 5, Issue 2

March-April 2015

8 RESEARCH ARTICLES

Dr. Patil Pratik M.1, Dr. Bobade Rajkumar B.2, Dr. Firke Arti R.3
1Assistant Professor, Dept. of Swasthavritta, Dr. D. Y. Patil College of Ayurved and Research Institute, Nerul, Navi-Mumbai, Email - pratik.patil@dypatil.edu
2Professor & HOD, Dept. of Swasthavritta, College of Ayurved & Research Center, Akurdi, Email- rajkumarbobade@gmail.com
3Associate Professor, Dept. of Swasthavritta, College of Ayurved & Research Center, Akurdi, Email- firkearti@yahoo.co.in

In today’s era, prevention has definitely a very important role in field of health sciences. A vital organ like eye is of great use without any doubt. Prevention of Eye from various diseases & maintaining the normal vision in today’s computerized and electronic world is of prime importance. For the same reason Ayurved had given very valuable remedies. Considering those parameters & data as a baseline, study was conducted on subjects with disorders related to eyes like Eye strain, Refractive errors, Dryness of Eyes, Lacrimation (Watering of eyes) etc. & were treated with study drug i.e. RUTU HARITAKI. Positive and very useful findings were observed which are discussed thoroughly in the Paper. Giving us a new Vision & ray of hope in field of Ophthalmology, not only in prevention but also in treatment of various diseases related to Eyes. REFERANCES 1) http://www.who.int/mediacentre/factsheets/fs282/en/ 2) Acharya Vidyadhar Shukla, Charak Samhita, , Vol. 01, Chowkhamba Sanaskrit Sansthan, Varanasi, 2002. Pg. no. 56-65. 3) Kaviraj Dr. Ambikadutta Shashtri, Sushrut Samhita, 12th Ed. Chowkhamba Sanaskrit Sansthan, Varanasi, 2001, pg. no. 334-348. 4) Kaviraj Atrideva Gupta, Ashtanga – Hrudaya, 14th Ed., Chowkhamba Krishnadas Acadamy, Varanasi. 2003, pg. no. 23-31. 5) Kaviraj Atrideva Gupta, Ashtanga – Sangraha, Vol. 1,Chowkhamba Krishnadas Acadamy,Varanasi, 2005, pg. no. 14-16. 6) Prof. K. R. Srikantha Murthy, Bavprakash, Vol. 01., Chowkhamba Krishnadas Acadamy, Varanasi, 2004. Pg. no. 67-87. 7) Shri Bramha Shankar Shastri, Yogaratnakar, Chowkhamba Sanaskrit Sansthan, Varanasi, 2004, pg. no. 108-110. 8) Dr. P. Himasagar Chandra Murthy, Sharangdhara Samhita, 1st Ed., Chowkhamba Sanaskrit Sansthan, Varanasi, 2001. Pg. no. 45-47. 9) K Park, Preventive & Social Medicine, 20th Ed., Bhanot Publication, Jabalpur, 2009, pg. no. 431-433. 10) Stephen J. H. Miller, Parson’s Diseases of Eye, 18th Ed. Churchill living stone, 1992 pg. 05-07. 11) Pandit Hemaraj Sharma, Kashyapa Samhita, Vol. 2, Chowkhamba Sanaskrit Sansthan, Varanasi, 1988, pg. 78-79.

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Dr. Santosh Kumar Nath1, Dr. Sandip Kumar Nath1
1Calcutta Institute of Technology, sandipnathin1996@redeffmail.com, Bharat Sevashram Sangha Hospital,Joka

Ayurveda is the indigenous system of medicine. At present this system of the medicine is accepted and it is widely practiced in Village and Cities of the Counties of the World. In the past period, the Ayurveda was to practice as Traditional medicine in India and also it was the ancient system of medicine all over the World. It was revealed from the books, name - Sanhitas of Charaka, Susruta and Vagbhata that Ayurveda is the Traditional medicine in India and also all over the World. The application of the Ayurveda medicines was mentioned of the above said books. The Ayurveda system was brought in our Society in the Vedic Period. This period was prior to 2500 B.C. and it is called Vedic Period. It was revealed from the ancient books that “LORD BODHA”. Practitioner was practiced of both Medicine and Surgery. At that time Surgery was not advanced like to-day, but the medicine was only the remedy of the Patient.. REFERANCES Kabiraj D. K. Roy, Author of Modern Ayurvedic Chikitsa; The Journal of Health of India; Literature of Swargashram Ayurvedic Aushdhalaya, U.P.; The Journal and Literature of Shri Ganga Pharmacy, U.P.; Literature of The Himalaya Drug Co.,Bangalore; Literature of The Baidyannath Drug Co., Kolkata; Who (1980). The WHO expert Committee on diabetes mellitus. Second report. Technical Report Series, Who, Genevapp.646; Joshi, S.G.(2000). Medicinal plants. Oxford and IBH Publishing Co. Pvt. Ltd. New Delhi; Kanjilal U.N. Kanjilal, P.C.Das, A. and Bor, N.L.(1934-1940), flora of Assam. Vol.-1-4 Ayurveda for you from Google; Deb, D.B (1981) flora of Tripura state. Vol-I, Today and Tomorrow Printer and Publisher, New Delhi; Ambasta, S.P.et al. The useful plants od India,CSIR,New Delhi; Ganulee, H.C. et al, College Botany, Vol-I, New Centre Book Agency, Calcutta, 195.

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Introduction: Life style disorders are one of the raising issues in present era. This is because what we do or what we think is what we are. Lifestyle disorders are set of diseases which are because of modified life style of present generation. That is why these are also known as Diseases of civilization. Obesity, metabolic syndrome, heart disease, asthma, some kinds of cancer, chronic liver disease, Diabetes (Type 2), and depression are some of diseases which are included under this. Incidence and prevalence of these are mainly seen in Urban and semi suburban areas than the rural areas. Drug abuse, sedentary lifestyle, tobacco and smoking are the major culprits among the causes of this. There is significant difference in the lifestyles of people of rural and urban areas. That is why a study was undertaken to highlight the incidence of health related issues particularly the lifestyle diseases in urban and rural areas. Material and Methods: It is a survey study. The mobile medical camp conducted at Gogunda tehsil of Udaipur district in the month of Feb. 2014 and Data recorded in the OPD of National institute of Ayurveda Hospital were taken respectively. The total population of five villages of Gogunda tehasil is Total 12461. In which 555 adult patients were surveyed. Data of 528 adult patients were recorded in NIA Jaipur during Feb.2014. Results & Discussion: Prevalence of some of the Lifestyle diseases like Diabetes2, Hypertension, Obesity, Depression in Urban area in comparison with rural is statistically significant. Even though the Prevalence of Acid peptic diseases in urban area were found to be more, it was found non-significant statistically. Probable reason for the significant prevalence of Lifestyle disorders in urban area could be the varied pattern of life style. Conclusion: Diet and lifestyle influence significantly on our health. We are going away from the traditional style of life in this era. This is evident when we look at the prevalence of lifestyle disorders. Urban style of life is mostly the base for these disorders. Whereas the rural style of life gives room for the deficiency disorders, communicable diseases and degenerative disorders. People of urban and sub urban areas are even though sophisticated in comparison with rural areas, they are unaware about the preventive aspects. That is why, awareness of health in terms of preventive aspects through Ayurveda is necessary in these areas. This type of health data should never be restricted for the purpose of statistics rather it need to be utilized in correcting the health related issues. REFERANCES 1. www.thehealthsite.com 2. www.rohiniwithfindings.wordpress.com 3. Ibid 4. www.science.gov/topicpages/p/promote+healthier+lifestyles.html 5. timesofindia.indiatimes.com/.../Lifes. 6. Gupta R. Trends in hypertension epidemiology in India. J Hum Hypertens. 2004; 18:738. 7. Reddy KS. Regional case studies–India. Nestle Nutr Workshop SerPediatrProgram. 2009;63:15-24; discussion 41-16, 259-268 8. www.diabetes.co.uk/...diabetes/diab 9. Ibid 10. Ibid 11. Ramachandran A, Snehalatha C, Kapur A, et al. Diabetes Epidemiology Study Group in India (DESI). High prevalence of diabetes and impaired glucose tolerance in India: National Urban Diabetes Survey. Diabetologia. 2001; 44:1094-1101. 12. www.care.diabetesjournals.org/.../1798 13. O P Gupta, Sanjeev Phatak. Pandemictrends inprevalenceofdiabetesmellitusandassociatedCoronaryheartdiseaseinIndia– Theircausesandprevention. Int. J. DIAB. Dev. Countries (2003), Vol. 23 14. Singh S, Kumar V, Kumar S, Subbappa A. The effect of periodontal therapy on glycemic control in patients with type-2 diabetes mellitus: A randomized controlled clinical trial. Int J Diabetes Dev Ctries. 2008; 28:38–44. 15. learningbuzz.wikispaces.com/ 16. timesofindia.indiatimes.com/India/

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K Aruna Gayathri, K.V. RamSubbarao, K.Ramanjaneyulu1
1K.Ramanjaneyulu.K3.Assistant professor,Vishnu Insitute of Pharmaceutical Sciences and Research, Narsapur, Medak, Telangana

Analgesic and anti- inflammatory activity for herbomineral formulation was evaluated by using hot plate method. Crude extract of herbomineral formulation was prepared by using tween 80.2 % crude drugs which is present in the form of suspension was administered through oral route at a dose of 100 mg/kg, 200 mg/kg in mice weighing between 20-25 g using oral gavage and evaluated for analgesic activity at different time intervals such as 0, 15, 30, 60 and 90 minutes against standard (Tramadol Hydrochloride 22.8 mg/kg i.p) and control group, P< 0.05 was considered as significant. At a dose 100 mg/kg herbomineral formulation had shown significant activity10.00 ± 1.10 (P < 0.001), 200 mg/kg had shown significant activity at15, 30, 60 and 90 min time interval (P<0.001). REFERANCES Dr.Naaginidas Chaganlal Shaw, Rasavaidya, Bharatha Bhaishagya Ratnakara, Rasaprakarana, Volume:V, Edtn.2005, Hindi Version,Pp.304. Kokate C.K. Practical Pharmacognosy. Vallabh prakashan New Delhi. Preliminary phytochemical screening, chapter 6, pp106-111. Phytocemical screening and in-vitro anti-oxidant activity of herbomineral compound named Trushanadiloha. Int. J. Res.Phytoche. Pharmacol, 1(4), 2011, 224 - 228. Shailendra S.Gurav, Vijay D.Gulkari, Nandkishore J.Duragkar and Aarun T. Patil IJPT January 2008 7(1) P.No.21-24. Khandelwal K.R.Practical Pharmacognosy. Nirali Prakashan Pune. Techniques and Experiments, Chapter 40,17th ed. pp149-153. Sharma MC, Smita Sharma: Some Plant extracts used in pharmacologically activity of Anxiolytics, Antidepressant, Analgesic, and Anti-inflammatory activity. Digest Journal of Nanomaterials and Biostructures. March 2010; 5 (1): 223 – 227. 7. Franzotti EM, Santos CVF. Anti-inflammatory, analgesic activity and acute toxicity of Sida cordifolia(L). (Malva-branca). J. Ethnopharmacol. 2000; 72:273-278. 8. Eddy NB, Leimback D. Synthetic analgesic. II. Dithienyl butenyl and dithienyl butyl amines. J Pharmacol ExpTher 1953; 107: 385-393. 9. Elisabetsky E, Amador TA. Analgesic activity of psy- chotria colorata (Willd.ex R. and S.). Muell. Arg. Alka- loids. J Ethnopharmacol.1995; 48: 77-83. 10. Jayaprakash GK, Rao LJ. Phenolic constituents from lichen Parmontrema stuppeum. (Nyl.) hale and their antioxidant activity. 2000; 55:1018-1022. 11. Mustaffa F, Indurkar J. Analgesic activity, toxicity study and phytochemical screening of standardized Cinnomomum iners leaves methanolic extract2010;2(2): 76-81. 12. Pal S, Sen T, A.K. Chaudhuri AK. Neuropsychopharma- cological profile of the methanolic fraction of bryo- phyllum pinnatum leaf extract. J Pharm Pharmacol 1999;51: 313-18.) 13. Priyanka Vijay, Rekha Vijay vergia. Analgesic, anti- inflammatory and antipyretic activity of Cissus quad- rangularis. Journal of Pharmaceutical Science and Technology 2010; 2 (1):111-118 14. Raquibul Hasan SM, Mariam Jamila: Analgesic and An-tioxidant Activity of the Hydromethanolic Extract of Mikania scandens (L.) Willd. Leaves. American Jour-nal of Pharmacology and Toxicology 2009; 4 (1): 1-7. 15. Sharma MC, Smita Sharma. Some Plant extracts used in pharmacologically activity of Anxiolytics, Antidepres-sant, Analgesic, and Anti-inflammatory activity. Di-gest Journal of Nanomaterials and Biostructures ,2010; 5 (1): 223 – 227. 16. Yerima M, Magaji MG: Analgesic and Anti-inflammatory activities of the Methanolic leaves ex-tract of Securinega virosa (Euphorbiaceae). Nig Journ Pharm Sci 2009; 8 (1): 47 – 53.

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Dr. Rajesh Gupta1, Dr. Lalita Meena1
1Head, Dept. of Shalya Tantra, University College of Ayurveda, Dr. Sarvepalli RadhaKrishnan Rajasthan Ayurved University, Jodhpur, EmailId:drrajaeshkumarguptagupta@yahoo.com, guptadrrajaeshkumargupta@gmail.com, Scholar MS (Shalyatantra)1st Year, University College of Ayurved, Dr. Sarvepalli RadhaKrashinan Rajasthan Ayurved University, Jodhpur, Email Id: doc.lalitanarera@gmail.com

Parikartika resembles fissure‑in‑ano which is very common among all ano‑rectal disorders. In Ayurvedic texts, Parikartika is described as a complication of Atisara and Virechana karma. Ksharasutra was proved successful in the management of fistula‑in‑ano, piles, and there is a need to try its efficacy in fissure‑in‑ano. This Study was conducted to evaluate the role of Apamarga Ksharasutra Stitching (AKSS) in fissure bed in chronic fissure‑in‑ano. 120 patients of chronic fissure‑in‑ano were selected and randomly divided into two groups (60 in each group). In group‑A, patients were treated with AKSS; while the patients of Group‑B with Anal dilatation followed by AKSS under pudendal block anesthesia. The AKSS was done once and after slough out of Ksharasutra, the wound was treated for 4 weeks and assessment of the result was done on the basis of gradation adopted. The pain relief on 14th day in Group‑A was 86% while in Group‑B 100% was observed. As on 7th day in Group‑A, oozing was stopped in 68% patients, while in Group‑B, oozing was stopped in 82% patients. On 21st day, Group‑B showed more healing (85%) as compared to Group‑A (69%). In this study 68% of patients were cured. In Group‑B (AKSS with anal dilatation) patients were cured early as compared to patients of Group‑A (AKSS alone). REFERANCES 1. Sushruta, Sushruta Samhita, Chikitsa Sthana, Vamana‑Virechan Vyapada Adhyaya, 34/37, edited by Shastri A, 12th ed. Chowkhambha Surabharati Sanshtan, Varanasi, 2001; 147. 2. Bhuyan C, Dudhamal TS, Gupta SK. A new technique for the treatment of Jeerna Parikartika w.s.r. to chronic fissure‑in‑ano. Indian J Anc Med Yoga 2010;3:133‑40. 3. Sharma KR, Sharma SK, Deshpande PJ. Conservative treatment of fissure‑in‑ano. Nagarjuna 1973;XVI: 56‑8. 4. Bhuyan C, Dudhamal TS, Gupta SK, Jaiswara S. Effect of Ksharakarma in Parikartika (acute fissure‑in‑ano). Indian J Anc Med Yoga 2009;2:65‑75 5. Goligher J. Fissure in ano. Surgery of the Anus Rectum and Colon. 5th ed. Delhi: A.I.T.B.S. Publishers and Distributors; 2002. pp. 150. 6. Vriddha Jivaka, Kashyapa Samhita, Khila Sthana, Antarvatni Adhaya, 10/102. edited by Tiwari PV, reprint ed. Chaukhambha Vishvabharati, Varanasi, 2008; 565. 7. Das S. Chronic fissure‑in‑ano. A Concise Textbook of Surgery. 6th ed. Kolkata: Dr. S. Das Publication; 2010. pp. 967. 8. Vagbhata, Astanga Hridayam, Nidansthana, Udaranidana Adhyaya, 12/1, edited by Shastri K, 1st ed. Krishnadas Academy, Varanasi, 1994; 133. 9. Williams NS, Bulstrode CJK, OConnell PR. Chronic fissure in ano. Baily and Love’s Short Practice of Surgery. 25th ed. Boca Raton: UK Hodder Arnold Part of Hachette; 2008. pp. 1252. 10. Goligher J. Fissure in ano. Surgery of the Anus Rectum and Colon. 5th ed. Delhi: A.I.T.B.S. Publishers and Distributors; 2002. pp. 158. 11. Jonas M, Scholefield JH. Anal fissure. Gastroenterol Clin North Am 2001;30:167‑81. 12. Anonymous. Ksharasutra (Medicated thread). Ayurvedic Pharmacopia of India. 1st ed., Part‑II. Vol. II., New Delhi: Dept. of AYUSH, Govt. of India; 2001. pp. 209‑13. 13. Sushruta, Sushruta Samhita, Sutra Sthana, Ksharapakavidhi Adhyaya, 11/3, edited by Shastri A, 12th ed. Chowkhambha Surabharati Sanshtan, Varanasi, 2001; 34. 14. Ibidem, Sushruta Samhita, Sutra Sthana, Ksharapakavidhi Adhyaya, 11/5; 34. 15. Rasik AM, Shukla A, Patnaik GK, Dhawan BN, Kulshrestha BK, Srivastava S. Wound healing activity of the latex of Euphorbia nerifolia Linn. Indian J Pharmacol 1996;28:107‑9. 16. Negi PS, Jayaprakasha GK, Jagan Mohan Rao L, Sakariah KK. Antibacterial activity of turmeric oil: A byproduct from curcumin manufacture. J Agric Food Chem 1999;47:4297‑300. 17. Synopsis of turmeric’s healing properties.(n.d.). Available from: http:// www.turmeric.co.in/turmeric_ayurvedic_use.htm. [Last accessed on 2012 Jan 12]. 18. Bhuyan C. Malasaya Roga Chikitsa Vignyan (Anubhuta Yoga). 1st ed. Puri: Indian Proctology Society; 1998. p. 38. 19. Jensen SL. Treatment of first episodes of acute anal fissure: Prospective randomised study of lignocaine ointment versus hydrocortisone ointment or warm sitz baths plus bran. Br Med J (Clin Res Ed). 1986 3;292:1167‑9. 20. Shri Krishnarams Bhatta, Sidhabhaishaja Manimala, Chturtha guchha, Udavarta Chikitsa 7, edited by Kaladhar Bhatt R, 2nd ed. Chowkhamba Krishnadas Academy, Varanasi, 1999; 257. 21. Panda AK, Debnath SK. Overdose effect of aconite containing Ayurvedic Medicine (‘Mahashankha Vati’). Int J Ayurveda Res 2010;1:183‑6. 22. Dorababu M, Prabha T, Priyambada S, Agrawal VK, Aryya NC, Goel RK. Effect of Bacopa monniera and Azadirachta indica on gastric ulceration and healing in experimental NIDDM rats. Indian J Exp Biol 2004;42:389‑97. 23. Pai MR, Acharya LD, Udupa KN. Evaluation of antiplaque activity of Azadirachta indica leaf extract gel – A 6‑week clinical study. J Ethnopharmacol 2004;90:99‑103. 24. Biswas K, Chattopadhyay I, Banerjee RK, Bandyopadhyay U. Biological activities and medicinal properties of Neem (Azadirachta indica). Curr Sci 2002;82:1336‑45.

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Keshwar Unmesh1, Pimplapure Soumit1, Dhurde Ss1, Shrikhande Bk1
1Siddhayu Ayurvedic Research Foundation Pvt. Ltd, Nagpur, India

Aim: The present study was designed with an objective of developing a validated, simple, accurate and precise HPTLC method for the determination of Diosgenin from Polyherbal Tablet containing Tribulus terrestris. Method: High performance thin layer chromatography (HPTLC) method was developed and validated for analysis of Diosgenin from polyherbal Tablet. Chromatographic separation was achieved on precoated silica gel HPTLC aluminum plate 60 F254 using Toluene: Acetone (8.5:1.5) as mobile phase. Detection was performed at 430 nm wavelength by TLC scanner (CAMAG). Results: The Rf value of Diosgenin was found to be 0.41 ± 0.02. The linear regression analysis data for calibration plots showed good linear relationship (r2 = 0.997) in the concentration range of 240 - 1440 ng/spot. The accuracy of the method was checked by conducting recovery studies at three different levels, using standard addition method. The average recovery of diosgenin was found to be 98.48 %. Precision (% RSD < 2%) of the developed HPTLC method was in accordance with the ICH guidelines. Conclusion: The developed procedure can be selectively used in the assay and quality control of Diosgenin from various Ayurvedic Polyherbal Tablet formulations without interference from other herbal ingredients and excipients. REFERANCES 1. Indian Herbal Pharmacopoeia. Revised new Edn, Indian Drug Manufacturers Association, Mumbai, 2002, 459-466. 2. Rajpal V. Standardisation of Botnicals. Vol. I, Eastern publishers, New Delhi, 2002, 223-228. 3. Kokate CK, Purohit AP, Gokhale SB. Pharmacognosy. Edn 33, Nirali Prakashan, Pune, 2005, 225-226. 4. The Useful Plants of India. Edn 3, Publications & Information Directorate, CSIR, New Delhi, 1994, 647-648. 5. Nadkarni KM. Indian Materia Medica. Edn 3, Vol. I, Popular Prakashan, Mumbai, 1976, 1229-1230. 6. Handa SS, Kapoor VK. Pharmacognosy. Edn 2, Vallabh Prakashan, Delhi, 1988, 229-230. 7. The Ayurvedic Pharmacopoeia of India. Edn 1, Part I, Vol. I, The Controller of Publications, Delhi, 1990, 40. 8. Dey AC. Indian Medicinal Plants used in Ayurvedic Preparations. Bishen Singh Mahendra Pal Singh, Dehra Dun, 1994, 52-53. 9. Tirtha SS. The Ayurveda Encyclopedia Natural Secrets to Healing, Prevention, & Longevity. Edn 1, Sri Satguru Publications, Delhi, 1998, 86. 10. Kshirsagar VB, Deokate UA, Bharkad VB, Khadabadi SS. HPTLC Method Development and Validation for the simultaneous Estimation of Diosgenin and Levodopa in marketed formulation. Asian Journal Research Chemistry 2008; 1(1): 36-39. 11. Parameswaran S, Koshti S. Quantitative Estimation of Piperine and Diosgenin in Ayurvedic formulation. British Journal of Pharmaceutical Research 2014; 4(8): 911-920. 12. Warke VB, Deshmukh TA, Patil VR. Development and Validation of RP-HPLC Method for Estimation of Diosgenin in Pharmaceutical dosage form. Asian Journal of Pharmaceutical & Clinical Research 2011; 4 (1): 126-128. 13. Ghodasara T, Gaudani R, Nayak B, Shingala D. HPTLC Method Development and Validation for the Simultaneous Estimation of Diosgenin and Gallic acid in marketed formulation. Pharma Science Monitor An International Journal of Pharmaceutical Science 2012; 3(4): 2664. 14. Jayaprakasm R, Ravit K, Athira K, Asha JB. Quantitative Determination Of Diosgenin In Polyherbal Formulation & Various Extracts of Smilax china Linn using standard marker by Validated Analytical Techniques. Universal Journal of Pharmacy 2013; 02(04): 83-90. 15. ICH Harmonized Tripartite Guideline. Validation of Analytical Procedures: Text and Methodology. Q2 (R1), November 2005.

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Saroj Kumar Debnath1*, Badri Prasad Shaw2, Badal Chandra Jana3
1Research Officer (Ayurveda), Central Ayurveda Research Institute for Drug Development, Kolkata, West Bengal, India, Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, Government of India
2Ex Professor and Head of the Department of Kayachikitsa, Institute of Post Graduate Ayurvedic Education and Research, Kolkata, 294/3/1, A.P.C. Road, Kolkata-700009
3Professor, Department of Rognidan, Institute of Post Graduate Ayurvedic Education and Research, Kolkata, 294/3/1, A.P.C. Road, Kolkata-700009

In the present clinical study 32 Amavata (Rheumatoid arthritis) patients were registered from the O.P.D. & I.P.D., Department of Kayachikitsa, Institute of Post Graduate Ayurvedic Education and Research, Kolkata. 30 patients completed the treatment out of 32 and 2 patients dropped out. The aim of the study was to evaluate the role of Ayurvedic management on Amavata (Rheumatoid arthritis). The treatment schedule was Sneha pana (Orally intake of Ayurvedic medicated oil), Niragnik swedana (Sweating by without heat), Virechan karma (Induced purgation by Ayurvedic procedure) and Vardhaman Pippali Rasayan sevan (Rejuvenation with orally intake of Piper longum mature dried fruit powder in gradual increased and decreased dose). In this clinical study 70% patients got major improvement, 30% patients got minor improvement, no improvement was nil and no one patient had got complete remission. Any complication was not found in this clinical study. REFERANCES 1 Harrison TR, Anthony S. Fauci et al. Harrison’s Principles of Internal Medicine, Ed 14, Vol. 2, McGraw Hill, New York, 1998, 1885. 2 Madhavakara, Rakshita V, Dutta S, Shastri S, Upadhyaya Y. Madhava Nidana (Madhukokosha Vyakya with Vidyotini Hindi Commentary), Ed 26, Part. I, Chaukhambha Sanskrit Sanathana, Varanasi, 1996, 460-464. 3 Chakrapanidutta, Sengupta D, Sengupta U, Sensharma K, Bhattacharya S. Chakradutta, Amavata Chikitsa, Ed 1, Deepayan, Kolkata, 1999, 138-141. 4 Agnivesha, Charaka, Dridhbala, Nag B. Charaka Samhita, Chikitsa sthan, Pratham adyaya, Ed 1, Nabapatra, Kolkata, 1988, 27-28. 5 Harrison TR, Anthony S. Fauci et al. Harrison’s Principles of Internal Medicine, Ed 14, Vol. 2, McGraw Hill, New York, 1998, 1885. 6 Govindadas, Sengupta V, Sensharma K, Bhattacharya S. Bhaishaijya Ratnavali, Amavatadhikar, Tritiya khanda, Ed 1, Deepayan, Kolkata, 2000, 44-54. 7 Das D, Das A. Statistics in Biology and Physiology, Ed 4, Academic Publishers, Kolkata, 2005, 1-137.

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Singh Rahul Kumar Singh Amrita Nathani Sumit Murthy A Rama1
1Lecturer, Dept. of P.G. Studies in Dravya Guna, Uttaranchal Ayurvedic College Dehradun, Uttarakhand

Adulteration may be defined as mixing or substituting the original drug material with other spurious, inferior, defective, spoiled, useless other parts of same or different plant or harmful substances or drug which do not confirm with the official standards. Adulteration in market samples is one of the greatest drawbacks in promotion of Ayurvedic products. Bharangi i.e. root of Rotheca serrata (L.) Steane & Mabb. is among those drugs which are commonly used in the indigenous system of medicine. This study was based on author's P.G. thesis (Singh & Murthy 2014, NIA Jaipur) work “Phytochemical study of certain genuine medicinal plant and their market samples” and after studying market samples of Bharangi it was found that all samples were adulterated and no any market sample had genuine drug Bharangi. Quality assurance of medicinal plant starting materials is of paramount importance to offer predictable efficacy of the Ayurvedic formulations. Since both the industry and the individual physician use these plants in a dry form, therefore a method to assess their genuineness in the dry form is the need of hour. Present era is the era of modern advancements but modern methods like microscopy, chemical assay etc. are the methods that require trained personals and well equipped laboratories that are not available to common physician. That’s why in this article efforts have been made to focus on cardinal organoleptic identifying features of genuine sample of Bharangi and its markets samples which helps to common physician for easy identification of genuine drug with adulterants. REFERANCES 1. Dorothy A. Steane and David J. Mabberley. 1998. "Rotheca (Lamiaceae) Revived". Novon 8(2):204-206. 2. Rosette B. Fernandes and Bernard Verdcourt. 2000. "Rotheca (Labiatae) revived - more new combinations". Kew Bulletin 55(1):147-154. 3. Steven J. Wagstaff, Laura Hickerson, Russ Spangler, Patrick A. Reeves, and Richard G. Olmstead. 1998. "Phylogeny in Labiatae s.l., inferred from cpDNA sequences". Plant Systematics and Evolution 209(3-4):265-274. 4. Sharma P.V. Classical uses of medicinal plants, Chaukhambha Vishvabharati, Varanasi, reprint – 2004, page 275-276. 5. Praveen kumar A & K. Nishteswar ; Phyto-chemical and Pharmacological Profiles of Clerodendrum serratum Linn.(Bharangi) : A Review, Int. J. Res. Ayurveda Pharm. 4 (2), Mar-Apr 2013, page 277-278. 6. Dr J.L.N. Sastry; Dravyaguna Vijnana vol.II, Chaukhambha Orientalia Varanasi, reprint – 20012, page 422. 7. Vaidya Bapalal; Nighantu Aadarsh; vol.II Chaukhambha Bharati Academy Varanasi, reprint – 2009, page 255. Thirumalai, M. Paridhavi And M. Gowtham; Evaluation Of Physiochemical, Pharmacognostical And Phytochemical Parameters Of Premna Herbacea ; Asian Journal Of Pharmaceutical And Clinical Research, Vol 6, Sup 1, 2013; page no -176

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