Volume 5, Issue 3

All most signs and symptoms of jaundice are much more similar to kamala ailment of ayurveda in various aspects. The classification of kamala is based on its origin and pathology. It is two types; Koshthashrit and shakhashrit. Koshthashrita kamala arises due to excess break down of erythrocytes, it is also called bahupitta kamala because increase the production of pitta. Second shakhashrita kamala arises due to intraheapatic cholestasis, here the cause kamala is only reduced the excretion of bilirubin, so called alp-pitta kamala. Both types of jaundice are very much close to the haemolytic and hepato-cellular jaundice of modern medical science. The persons taking wholesome food do not suffer from disease caused by the same because the use of wholesome food alone is not able to avert the fear of all diseases as there are other etiological factors even except the use of unwholesome food. In case of due to certain reasons such as unwholesome articles are not equally deranging nor have the dosas equal strength , all persons also are not equally capable to resist the disease (have no equal immunity). Because the resistant of body against disease makes with several elements like prakriti, sara, sanghanan, ahar shakti. abhyaranana shakti, vyayamshakti, vaya, dehsa and kala etc. REFERANCES [1]. Charaka Samhita With “Vidyotini” Hindi Commentary By Pt. Kashinath Shastry And Dr. Gorakhnath Chaturvedi, Part 1, Chaukhambha Bharati Academy,1996. Reprint-2013.pp. 166 [1]. Charaka Samhita With “Vidyotini” Hindi Commentary By Pt. Kashinath Shastry And Dr. Gorakhnath Chaturvedi, Part 1 &2, Chaukhambha Bharati Academy,1996. Reprint-2012.pp.573 and 505 [1]. Charaka Samhita With “Vidyotini” Hindi Commentary By Pt. Kashinath Shastry And Dr. Gorakhnath Chaturvedi, Part 2, Chaukhambha Bharati Academy,1996. Reprint-2012.pp.953 [1]. Charaka Samhita With “Vidyotini” Hindi Commentary By Pt. Kashinath Shastry And Dr. Gorakhnath Chaturvedi, Part 2, Chaukhambha Bharati Academy,1996. Reprint-2012.pp.505 [1]. Charaka Samhita With “Vidyotini” Hindi Commentary By Pt. Kashinath Shastry And Dr. Gorakhnath Chaturvedi, Part 2, Chaukhambha Bharati Academy,1996. Reprint-2012.pp.505 [1]. Ashtanga Hridaya (A Compendium Of The Ayurvedic System) Of Vagbhata With Commentaries Of Sarvangasundra Of Arunadatta & Ayuvesarasayana Of Hemadri, Annovated By Anna Moreshwar Kunte & Krsna Ramachandra Sastri Narve, Published By Chaukhambha Sanskrit Sansthan, Varanasi. Edi. & Reprint 2009.Pp-7 [1]. Ashtanga Hridaya (A Compendium Of The Ayurvedic System) Of Vagbhata With Commentaries Of Sarvangasundra Of Arunadatta & Ayuvesarasayana Of Hemadri, Annovated By Anna Moreshwar Kunte & Krsna Ramachandra Sastri Narve, Published By Chaukhambha Sanskrit Sansthan, Varanasi. Edi. & Reprint 2009.Pp-8 [1]. Charaka Samhita With “Vidyotini” Hindi Commentary By Pt. Kashinath Shastry And Dr. Gorakhnath Chaturvedi, Part 1, Chaukhambha Bharati Academy,1996. Reprint-2013.pp. 166 [1]. Charaka Samhita With “Vidyotini” Hindi Commentary By Pt. Kashinath Shastry And Dr. Gorakhnath Chaturvedi, Part 1, Chaukhambha Bharati Academy,1996. Reprint-2013.pp. 781 [1]. PARK K. Preventive and Social Medicine, 20th Ed M/S Banarasidas Bhanot Publisher (2009).pp192 1.

The present study was conducted to find out the effect of AtiBala (Abutilon indicum) as a single drug for Garbhasthapakaprabhava and Garbhavruddhikaraprabhava in pregnancy in growth retarded symptoms. Sixty pregnant women of a second and third trimester were included and they were divided into two groups. The effect of Ati Bala ‘choorna’ was compared to the choorna combination of Amalaki, Godanthi and Garbhapalarasa (Amalaki group). The role of Ati Bala in maintaining Garbha sthapaka and Garbha vruddhikaraprabhava was more than the combination of Amalaki, Godanthi and Garbhapalarasa, which was statistically significant. REFERANCES 1. 1. Ashtanga Sutrasthan 12-82, 13-3, 15-4, 20-4,5, 5-24 2. Ashtanga Samgraha Sharira Sthan 1-47, 54, 57, 63, 64, 2-3, 6, 23, 24, 56, 85, 3-5, 4-3, 11, 12, 27, 5-9, 10, 11, 12 3. Bhava Prakasha 24-15, 70-71, 72 4. Charaka Samhita Chikithsa 2-30, 46, 8-33, 34, 35, 36, 37, 30-16, 20 5. Charaka Samhita Nidana 1-8, 9, 12 6. Charaka Samhita Sharir 1-19,77, 2-4, 6, 15, 23, , 31, 33, 35, 3-1, 3, 4, 5, 7, 8, 9, 10, 11, 12, 13, 14, 17, 4-4, 5, 6, 7, 11, 12, 16, 18, 21, 26, 29, 30 7. Chopra R.N, Nayar S.L, Chopra I.C. Abutilon (Malvacene) Glossary of Indian Medicinal plants with active principles 1965-1981 Part 1 8. Dhanalaxmi S, Laxmanan K.K, Subramanyan M.S. Pharmacological and Phytochemical studies on two species of Abutilon, Department of Botany, Bharathiar University Tamilnadu 9. Dayani S, Mistry IU , Skandhan KP. Standardization of preparation of choorna with special reference to Ati Bala. Int J Ayurveda Hebal Medicine, 2015(In press). 10. Report on identification of high risk families, mothers and outcome of their offsprings, ICMR Task Force Study, ICMR New Delhi, 1990 11. Tiwari P.V. Ayurveda PrasutiTantraEvamStreeRoga Part 1, ChwakambhaOrientalia Varanasi, 1986 12. Dutta D.C. Text book of Obstetrics New Central Book Agency, Culcutta 3rd edition 1997 13. Hoffman BL, Well woman care In: Hoffman BL Schorge, Schaffer JI, Halvorson LM, Bradshaw KD, Cunningham FG. Williams Gynecology. New York, McGraw Hill Medical 2012. P2 14. Carigo SD et al. Ultrasound predictors of nconatul outcome intrauterine growth restriction PMID 8989476. 15. Charaka Chikithsa /2-30,46/ 8-33,34, 35, 36, 37/ 30-16 16. Charaka Nidana /1-8, 9 ,12 17. Charaka Shariara /1-19,77 / 2-4,16------------ 1,3,4,5,7,8,9,10,11,12,13,14,17,325 /4-41,5,6,7,11,12,16,18,21,26,29----- / 6-23/ 7-17/ 8-4,5,6,7,11,17,20,21,23,24,26,27,28,29,30,32,33,53------ 18. Charaka Sutrasthem /1-26/2 (charaka) /3-3—2,7,8,9,15,17-------------- 7,8,9 /17-14, /20/22/25/26-18/30-26 19. Charaka Vimanastham /5-8,24 /8-12, 95, 98 20. Worked Health Organization WHO were of mother and baby at the health centre Pg no: 109-112, 1992 21. World Health Organization 1994 Pg. 105 22. Craigo SD et al. Ultrasound predictors of national outcome intra uterine growth restriction PMID 8989476 23. Pelg D, Kennedy CM, Hunter SK: Intra uterine growth restriction identification and management Am Fam Physician 58:453-460 .

In today’s era, prevention has definitely a very important role in field of health sciences. A vital organ like eye is of great use without any doubt. Prevention of Eye from various diseases & maintaining the normal vision in today’s computerized and electronic world is of prime importance. For the same reason Ayurved had given very valuable remedies. Considering those parameters & data as a baseline, study was conducted on subjects with disorders related to eyes like Eye strain, Refractive errors, Dryness of Eyes, Lacrimation (Watering of eyes) etc. & were treated with study drug i.e. RUTU HARITAKI. Positive and very useful findings were observed which are discussed thoroughly in the Paper. Giving us a new Vision & ray of hope in field of Ophthalmology, not only in prevention but also in treatment of various diseases related to Eyes. REFERANCES 1. 1) http://www.who.int/mediacentre/factsheets/fs282/en/ 2) Acharya Vidyadhar Shukla, Charak Samhita, , Vol. 01, Chowkhamba Sanaskrit Sansthan, Varanasi, 2002. Pg. no. 56-65. 3) Kaviraj Dr. Ambikadutta Shashtri, Sushrut Samhita, 12th Ed. Chowkhamba Sanaskrit Sansthan, Varanasi, 2001, pg. no. 334-348. 4) Kaviraj Atrideva Gupta, Ashtanga – Hrudaya, 14th Ed., Chowkhamba Krishnadas Acadamy, Varanasi. 2003, pg. no. 23-31. 5) Kaviraj Atrideva Gupta, Ashtanga – Sangraha, Vol. 1,Chowkhamba Krishnadas Acadamy,Varanasi, 2005, pg. no. 14-16. 6) Prof. K. R. Srikantha Murthy, Bavprakash, Vol. 01., Chowkhamba Krishnadas Acadamy, Varanasi, 2004. Pg. no. 67-87. 7) Shri Bramha Shankar Shastri, Yogaratnakar, Chowkhamba Sanaskrit Sansthan, Varanasi, 2004, pg. no. 108-110. 8) Dr. P. Himasagar Chandra Murthy, Sharangdhara Samhita, 1st Ed., Chowkhamba Sanaskrit Sansthan, Varanasi, 2001. Pg. no. 45-47. 9) K Park, Preventive & Social Medicine, 20th Ed., Bhanot Publication, Jabalpur, 2009, pg. no. 431-433. 10) Stephen J. H. Miller, Parson’s Diseases of Eye, 18th Ed. Churchill living stone, 1992 pg. 05-07. 11) Pandit Hemaraj Sharma, Kashyapa Samhita, Vol. 2, Chowkhamba Sanaskrit Sansthan, Varanasi, 1988, pg. 78-79.

Cancer is a significant global healthcare problem, with an estimated worldwide incidence of 10 million new cases per year, 46% of which are in developed countries. Mortality is high, with >7 million deaths per year. The goal of cancer treatment is first to eradicate the cancer. If this primary goal cannot be accomplished, the therapeutic goal shifts to palliation, the amelioration of symptoms, and preservation of the patient’s quality of life (QOL). In the last two decades, great advances have been made in cancer therapy; however, the success rates still remain unsatisfactory. Current conventional anticancer therapies are associated with adverse effects, drug resistance, and cancer recurrence. Therefore, there is still an urgent need for new therapeutic options for cancer. Current evidence, based on preclinical studies suggests that some Unani medicinal plants have anticancer potential. This review offers an evidence-based perspective of 20 Unani herbal drugs for the prevention and treatment of cancer. Several mechanisms are likely to account for the observed pharmacological effects, the most important being direct cytotoxicity, apoptosis induction, anti-oxidation, and immunomodulation. These Unani herbal drugs when combined with conventional anticancer therapy may help to synergize the anticancer effects, and reduce the side effects of conventional drugs, to improve the patient’s QOL, and to prevent cancer recurrence. However, well-designed and well-executed randomized controlled clinical trials (RCTs) are required to validate their usefulness and to make their use acceptable clinically in different types of cancers. Thus, these Unani medicinal plants may have turned into anticancer drugs. REFERANCES 1. 1. Colledge NR, Walker BR, Ralston SH. Davidson’s Principles and Practice of Medicine. Edn 21, Churchill Livingstone, Elsevier Ltd, Philadelphia, 2010, 255-277. 2. Munjal YP, Sharma SK, Agarwal AK, Gupta P, Kamath SA, Nadkar MY, et al. API Textbook of Medicine. Edn 9, Vol. 2, The Association of Physicians of India, JP Brothers Medical Publishers (P) Ltd, 2012, 1556-1575. 3. Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J. Harrison’s Principles of Internal Medicine. Edn 18, Vol. 1, McGraw-Hill Companies, USA, 2012, 646-711. 4. Kumar V, Abbas AK, Fausto N, Aster JC. Robbins and Cotran Pathologic Basis of Disease. Edn 8, Saunders, Elsevier, Philadelphia, 2010, 292-366. 5. Williams NS, Bulstrode CJK, O’Connell PR. Bailey & Love’s Short Practice of Surgery. Edn 26, CRS Press, Taylor & Francis Group, Boca Raton, US, 2013, 125-146. 6. Goldman L, Schafer AI, Arend WP, Armitage JO, Clemmons DR, Drazen JM, et al. Goldman’s Cecil Medicine. Edn 24, Saunders, Elsevier, Philadelphia, 2012, 1164-1177. 7. Saad, B, Azaizeh H, Said O. Arab Herbal Medicine. Botanical Medicine in Clinical Practice. 2008; 4: 31. 8. Warrell DA, Cox TM, Firth JD, Benz Jr EJ. Oxford Textbook of Medicine. Edn 4, Vol. 1, Oxford University Press, New York, 2003, 193-260. 9. Shafi G, Hasan TN, Syed NA, Al-Hazzani AA, Alshatwi AA, et al. Artemisia absinthium (AA): a novel potential complementary and alternative medicine for breast cancer. Mol Biol Rep. 2012; 39(7):7373-9. 10. Suresh V, Sruthi V, Padmaja B, Asha VV. In vitro anti-inflammatory and anti-cancer activities of Cuscuta reflexa Roxb. J Ethnopharmacol. 2011; 134(3): 872-7. 11. Chatterjee D, Sahu RK, Jha AK, Dwivedi J. Evaluation of antitumor activity of Cuscuta reflexa Roxb. (Cuscutaceae) against Ehrlich Ascites Carcinoma in Swiss albino mice. Trop J Pharmaceu Res. 2011; 10(4): 447-454. 12. Udavant PB, Satyanarayana SV, Upasani CD. Preliminary screening of Cuscuta reflexa stems for anti-inflammatory and cytotoxic activity. Asi Paci J Trop Biomed. 2012; S1303-S1307. 13. Yahayo W, Supabphol A, Supabphol R. Suppression of Human Fibrosarcoma Cell Metastasis by Phyllanthus emblica Extract in Vitro. Asian Pac J Cancer Prev. 2013; 14(11): 6863-6867. 14. Haque R, Bin‑Hafeez B, Ahmad I, Parvez S, Pandey S, Raisuddin S. Protective effects of Emblica officinalis Gaertn. in cyclophosphamide-treated mice. Hum Exp Toxicol. 2001; 20:643‑50. 15. Hari KB, Sabu MC, Lima PS, Kuttan R. Modulation of haematopoetic system and antioxidant enzymes by Emblica officinalis gaertn and its protective role against γ-radiation induced damages in mice. J Radiat Res. 2004; 45:549-5. 16. Jindal A, Soyal D, Sharma A, Goyal PK. Protective effect of an extract of Emblica officinalis against radiation-induced damage in mice. Integr Cancer Ther. 2009; 8:98-105. 17. Singh I, Sharma A, Nunia V, Goyal PK. Radioprotection of Swiss albino mice by Emblica officinalis. Phytother Res. 2005; 19:444‑46. 18. Singh I, Soyal D, Goyal PK. Emblica officinalis (Linn.) fruit extract provides protection against radiation‑induced hematological and biochemical alterations in mice. J Environ Pathol Toxicol Oncol. 2006; 25:643‑54. 19. Sultana S, Ahmed S, Jahangir T. Emblica officinalis and hepatocarcinogenesis: A chemopreventive study in Wistar rats. J Ethnopharmacol. 2008; 118:1-6. 20. Jayaprakasam B, Zhang Y, Seeram NP, Nair MG. Growth inhibition of human tumor cell lines by withanolides from Withania Somnifera leaves. Life Sci. 2003; 74:125-32. 21. Yadav B, A. Bajaj A, Saxena M, Saxena AK. In Vitro Anticancer Activity of the Root, Stem and Leaves of Withania somnifera against Various Human Cancer Cell Lines. Indian J Pharm Sci. 2010; 72(5): 659-663. 22. Nema R, Khare S, Jain P, Pradhan A. Anticancer Activity of Withania somnifera (Leaves) Flavonoids Compound. Int J Pharm Sci Rev Res. 2013; 19(1): 103-106. 23. Rathi SG, Suthar M, Patel P, Bhaskar VH, Rajgor NB. In-vitro Cytotoxic Screening of Glycyrrhiza glabra L. (Fabaceae): A Natural Anticancer Drug. J Young Pharm. 2009; 1(3): 239-243. 24. Rahman S, Sultana S. Glycyrrhizin exhibits potential chemopreventive activity on 12-O-tetradecanoyl phorbol-13-acetate-induced cutaneous oxidative stress and tumor promotion in Swiss albino mice. J Enzyme Inhib Med Chem. 2007; 22: 363-369. 25. Nair PKR, Melnick SJ, Wnuk SF, Rapp M, Escalon E, Ramachandran C. Isolation and characterization of an anticancer catechol compound from Semecarpus anacardium. J Ethnopharm. 2009; 122(3): 450-456. 26. Sugapriya D, Shanthi P, Sachdanandam P. Restoration of energy metabolism in leukemic mice treated by Semecarpus anacardium Linn. nut milk extract. Chem Biol Interact. 2008; 173:43-58. 27. Mathivadhani P, Shanthi P, Sachdanandam P. Apoptotic effect of Semecarpus anacardium nut extract on T47D breast cancer cell line. Cell Biol Int. 2007; 31:1198-1206. 28. Dinesh MG, Rajasekaran S, Suneel R, Chandrasekaram K, Kalaivani R. Terminalia bellerica leaf extracts induce apoptosis in HepG2 cells and regulates cell cycle progression by inducing G2/M cell cycle arrest. Indian J Res Pharmacy Biot. 2014; 2(1): 1044-1057. 29. Kumudhavalli MV, Vyas M, Jayakar B. Phytochemical and pharmacological evaluation of the plant fruit of Terminalia belerica Roxb. Int J Pharmac Life Sci. 2010; 1(1):1-11. 30. Subbarayan PR, Sarkar M, Impellizzeri S, Raymo F, Lokeshwar BL, Kumar P, Agarwal RP, Ardalan B. Anti-proliferative and anti-cancer properties of Achyranthes aspera: specific inhibitory activity against pancreatic cancer cells. J Ethnopharmacol. 2010; 131(1): 78-82. 31. Geetha P, Narayanan KR, Murugesan AG. Screening the Anti-Cancerous Efficacy of Achyranthes aspera Linn. using Animal Model Swiss Albino Mice. J Biomed Sci and Res. 2010; 2(4): 231-235. 32. Singh SK, Shanmugavel M, Kampasi H, Singh R, Mondhe DM, Rao JM, Adwankar MK, Saxena AK, Qazi GN. Chemically standardized isolates from Cedrus deodara stem wood having anticancer activity. Planta Med. 2007; 73(6): 519-26. 33. Gaidhani SN, Singh A, Kumari S, Lavekar GS, Juvekar AS, et al. Evaluation of some plant extracts for standardization and anticancer activity. Indian J Traditional Knowledge. 2013; 12(4): 682-687. 34. Bhushan S, Singh J, Rao JM, Saxena AK, Qazi GN. A novel lignan composition from Cedrus deodara induces apoptosis and early nitric oxide generation in human leukemia Molt-4 and HL-60 cells. Nitric Oxide. 2006; 14(1):72-88. 35. Ali H, Dixit S. Extraction optimization of Tinospora cordifolia and assessment of the anticancer activity of its alkaloid palmatine. The Scient World J. 2013, 1-10. 36. Mishra A, Sharma AK, Kumar S, Saxena AK, Pandey AK. Bauhinia variegata leaf extracts exhibit considerable antibacterial, antioxidant, and anticancer activities. Bio Med Res Int. 2013, 1-10. 37. Verma R, Chaudhary HS, Agrawal RC. Evaluation of Anticarcinogenic and Antimutagenic Effect of Tinospora cordifolia in Experimental Animals. J Chem Pharm Res. 2011; 3(6):877-881. 38. Khan N, Sultana S. Anticarcinogenic effect of Nymphaea alba against oxidative damage, hyperproliferative response and renal carcinogenesis in Wistar rats. Mol and Cell Biochem. 2005; 271(1-2):1-11. 39. Arzu BY, Fatma PK, Arzu UT. In vitro antibacterial and antitumor activities of some medicinal plant extracts, growing in Turkey. Asi Pacif J Trop Med. 2012; 616-624. 40. Meenavangalapati, Prakash SDV, Satyanandam S. In-vitro anti-cancer studies of Chebulinic acid on colon adenocarcinoma ht-29 cell lines. Int J Pharm Pharm Sci. 2013; 5(2): 582-583. 41. Ahuja R, Agrawal N, Mukerjee A. Evaluation of anticancer potential of Terminalia chebula fruits against Ehrlich Ascites Carcinoma induced cancer in mice. J Scient Innovat Res. 2013; 2(3): 549-554. 42. Priscilla D, Jasmine R. Assessing the potential of the ethanolic extracts of Terminalia chebula against breast cancer. World J Pharmacy Pharmaceut Sci. 2013; 2(6): 5702-5708. 43. Son YO, Kim J, Lim JC, Chung Y, Chung GH, Lee JC. Ripe fruits of Solanum nigrum L. inhibit cell growth and induce apoptosis in MCF-7 cells. Food Chem Toxicol. 2003; 41: 1421-1428. 44. Jeong JB, Jeong HJ, Park JH, Lee SH, Lee JR, et al. Cancer-preventive peptide lunasin from Solanum nigrum L. inhibits acetylation of core histones H3 and H4 and phosphorylation of retinoblastoma protein (Rb). J Agric Food Chem. 2007; 55: 10707-13. 45. Oskoueian E, Abdullah N, Saad WZ, Omar AR, Ahmad S, Kuan WB, Zolkifli NA, Hendra R, Ho YW. Antioxidant, anti-inflammatory and anticancer activities of methanolic extracts from Jatropha curcas Linn. J Med Plant Res. 2011; 5(1):49-57. 46. Bagya SK, Rajashree PV, Sam KG. Preliminary anticancer screening and standardization of some indigenous medicinal plants using cell biology and molecular biotechnology based models. Res J Med Plant. 2011; 5(6): 728-737. 47. Balakrishnan SK, Bhat KI. Apoptosis and flowcytometric studies of Bauhinia variegata bark extract. Asi J Pharmaceut Cl Res. 2014; 7(1): 48. Mishra R, Kaur G. Aqueous ethanolic extract of Tinospora cordifolia as a potential candidate for differentiation based therapy of glioblastomas. PLOS ONE. 2013; 8(10): 1-13. 49. Sinha K, Verma AK. Evaluation of antimicrobial and anticancer activities of methanol extract of in vivo and in vitro grown Bauhinia variegata L. Int Res J Biol Sci. 2012; 1(6): 26-30. 50. Kumar MH, Ramesh C. Anticancer activity of Nano encapsulated formulation from the extracts of Picrorhiza kurroa against human cancer cell lines. J Pharmacog and Phytochem. 2014; 2(5): 182-185. 51. Rajkumar V, Guha G, Kumar RA. Antioxidant and anti-neoplastic activities of Picrorhiza kurroa extracts. 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Rasashastra, the very special branch of Ayurveda includes various kalpas like Survana kalpa, Lauha kalpa,Vasant kalpa,Malla kalpa,etc. Out of which Vasant kalpa implies to Ayurveda medicines with particular common ingredients and specific way of preparation. The word Vasant symbolizes greenery and reproduction. The advent of spring brings new leaves, blossoming flowers, old bark of trees are replaced by new one, same changes are brought to human body by Vasant kalpa. In this most modern era with troubling food habits and lifestyle, everyone is struggling for more and more immunity. So the role of Vasant kalpas in leading problems like Vandhyatwa Prameha, Durdhara Vyadhis etc. will be studied thoroughly in paper. REFERANCES 1. 1. Vd S. D. Kulkrni, Ayurvedic Rasaoshadhi Nirmana, continental publication, Pune, 1981 2. Vd Ganagadharashastri Gune, Ayurvediya Aushsadhi gunadharma Shastra, Vaidyaka Granth Bhandara, Pune, 2001 3. Nagindasa Ghaganlal Shaha, Bharata Bhaishajya Ratnakara, B Jain Publication, New Delhi, 2005 4. Vd Y. G. Joshi, Charaka Samhita, Vaidyamitra Prakashana, Pune 5. Vd Ganesha Krushna Garde, Ashtanga Hridaya, Profishant publication house, Pune, 2010 6. Vd Sidhinandan Mishra, Ayurvediya Rasashastra, Choukhmba orientaliya, Varanasi, 2006 7. Shree Baidyanatha Ayurveda Bhavana Ltd., Ayurveda Sarasangraha, Kolkatta 2011 8. Krushna Gopala Ayurveda bhavana, Rasatantrasara Sangraha, 2009

The contemporary lifestyle disorders in India today impose a heavy load on the society and are a new national actuality. Amlapitta (Gastritis) is a very common emerging disease which is an abnormal pathological condition of pitta occurring due to faulty dietary habits, persistent intense stress, excess alcohol consumption, spicy and oily food. Here a single patient case study was done with pre test, follow up and post test evaluation by intervening a dravya Shatavari in granule form prescribed in 4 gm dosage daily in two divided doses before meals. A Proforma was designed containing Pathyaapathya which was advised to patient. Through this case study it was concluded that shatavari granules and advised Pathyaapathya regimen was helpful in curing amlapitta and maintain quality of life. REFERANCES 1. Agnivesha. “Charaka Samhita”, Revised by Charaka and Dridhabala with the Ayurvedadipika’s Hindi Ayushi commentary of Chakrapanidatta, edited by Harish Chandra singh Kushwaha.Chaukhambha Orientalia, Varanasi reprint Ed., 2009, Sutra.1/24, pp 964, Pg 598. 2. Sushrutha. “Sushrutha Samhita”, Revised by Nagarjuna, edited by Dr. Anantarama Sharma, Chaukhambha Surbharati Prakashan, Varanasi, Vol- I, Sutr.46/301, pp 600, Pg 423. Vagbhata. “AstangaHrdayam”, with Maulik siddhant Evum Ashtang hriday Marathi translation Edited by Dr.Dinesh Todkari, Wizcraft Publications & Distributions, Solapur, First Edition 2015, Sutra.6/98, pp 357, Pg 82. 4. Singh S.K, Kulkarni K.S, Obs & Gyn. Today, 2002, 12, 727.

Dhatura (Datura innoxia Mill.) belonges to family Solanaceae describe in Ayurveda for the various types of treatments to cure disease conditions in Classical texts. As a named the people knows Dhatura a very dangerous toxic plant. But, in presented review article, an attempt has been made to compile critically its informations related to therapeutic uses of dhatura from more than three samhitas, nine samgraha granthas, seven nighantus and other published texts. It is observed that root, root bark, leaves, seed, oil of Dhatura are used as an ingredient in 521 formulations, which are effective in more than 50 disease conditions. The main indications include vatavyadhi (diseases of joints), aamavata (rheumatoid artharitis), vrana (wound), agnimandya (loss of appetite), jvara (fever), grahani (Irritable bowel syndrome), shiroroga (disease of head), Shotha (inflammation), hikka (hiccough), kushtha (skin disease), visarpa (erysipelas), arsha (piles) etc. Different parts of Dhatura are used in about 18 dosage forms; such as svarasa (juice), kvatha (decoction), lepa (paste), varti (suppository), avaleha (semi-solid preparations), taila (oil), rasa (mineral preparation), vati (pills), modaka (solid dosage form), ghrita (fat soluble preparations), churna (powder), dhumrapaan (smoke inhalation), etc. REFERANCES 1. Dr. Gyanendra Pandey. System of Plant Nomenclature in Ayurveda. Edn. II, Chowkhambha Sanskrit Series Office, Varansi, 2011. 2. Doshi Krunal, Acharya Rabinarayan. Therapeutic importance of Eranda (Ricinus communis Linn.) in Ayurveda - a Review. Ayurpharm Int J Ayur Alli Sci. 2013; 2(9):281-295. 3. D. S. Lucas. Dravyaguna-Vijnana. Edn 1st, Vol 2, Chaukhambha vishvabharati, Varanasi, 2008, 306. 4. Sharma PV, editor. Dhanvantari Nighantu. Edn. 3rd, Chaukhambha Orientalia, Varanasi, 2002, 122. 5. Kaiyadeva. Kaiyadeva Nighantu. Sharma PV, Guru Prasad Sharma, editors. Edn 1st, Chaukhambha Orientalia, Varanasi, 1979, 632. 6. Bhavamishra. Bhavaprakasha Nighantu. Pandey GS, editor, Edn 1st, Chaukhambha Bharati Academy, Varanasi, 2006, 303. 7. Shaligram Vaishya. Shaligramanighantu Bhushanam. Edn 1st, Khemraj Shrikrishnadas Prakashan, Mumbai, 2002, 233. 8. Kamat SD, editor. Sarasvati Nighantu. Edn 1st, Chaukhamba Sanskrit Pratishthan, Delhi, 2006, 43. 9. Sharma PV. Priya Nighantu. Edn 1st, Chaukhambha Surbharti Prakashan, Varanasi, 2004, 113. 10. Dr. J.L.N. sastry. Ayurvedokta Oushadha niruktamala. Edn 1st, Chaukhambha Orientalia, Varanasi, 2001, 51. 11. Monier Williams. A Sanskrit-English Dictionary. Bharatiya Granthh Niketan, New Delhi, 2007. 12. Vaman Shivram Apte. The Student’s Sanskrit-English Dictionary. Edn 13th, Motilal Banarasidas Prakashan Private limited, Delhi, 2011. 13. Pandit Narahari. Raja Nighantu. Indradeo Tripathi, editor. Edn 3rd, Krishnadas Academy, Varanasi, 2003, 300. 14. Ibid. 3 Dravyaguna-Vijnana. 304. 15. Ibid. 4 Dhanvantari Nighantu. 122. 16. Ibid 5. Kaiyadeva Nighantu. 632. 17. Ibid 6. Bhavaprakasha Nighantu. 303. 18. Ibid. 7. Shaligramanighantu. 233. 19. Ibid. 11. Priya Nighantu. 113. 20. Sharangadhara. Sharangadhara Samhita. Srikanta Murthy KR, editor. Edn 4th, Chaukhambha Orientalia, Varanasi, 2001. 21. Chakrapanidutta. Chakradutta. Indradev T, editor. Edn IV, Chaukhamba Sanskrit Sansthan, Varanasi, 2002. 22. Vangasena. Vangasena Samhita. Saxena N, editor. Edn 1st, Vol. I and II, Chaukhamba Sanskrit Series office, Varanasi, 2004. 23. Rasavagbhata. Rasaratnasamuchchaya. Shastri AD, editor. Edn 3rd, Chaukhamba Orientalia, Varanasi, 1995. 24. Shri Govind Das. Bhaishajyaratnavali. Mishra BS, Shastri AD, Shastri RD, editors, Edn 19th, Chaukhmbha Prakashan, Varanasi, 2008. 25. Tripathi ID, Tripathi DS. Yogaratnakar. Edn 1st, Krishnadas Academy, Varanasi, 1998. 26. Acharya Dhundhuka Nath. Rasendrachintamani. Misra SN, editor. Edn 1st, Chaukhambha Orientalia, Varanasi, 2000. 27. Sri Gopal Krishna. Rasendrasarsangraha (Hindi). Satyartha P, editor. Edn 1st, Krishnadas Academy, Varanasi, 1992. 28. Shadanand Sharma. Rasa Tarangini. Kashinath Shastri, editor, Edn 11th, Motilal banarasidas, Varansi, 2009. 29. Shah NC, editor. Bharatbhaishajyaratnakara. Vol. 1 to 5. Edn 1st, B Jain Publishers, New Delhi, 2005. 30. Bharatbhaishajyaratnakara. Shah NC, editor. Vol. 1 to 5. Edn 1st, B Jain Publishers, New Delhi, 2005. Bruhad nighantu ratnakar. 31. Bharatbhaishajyaratnakara. Shah NC, editor. Vol. 1 to 5. Edn 1st, B Jain Publishers, New Delhi, 2005. Rasa kamadhenu. 32. Bharatbhaishajyaratnakara. Shah NC, editor. Vol. 1 to 5. Edn 1st, B Jain Publishers, New Delhi, 2005. Gadanigrah. 33. Pandit Narahari. Raja Nighantu. Indradeo Tripathi, editor. Edn III, Krishnadas Academy, Varanasi, 2003, 301.

The study was aimed to evaluation of the anticancer (liver cancer) activity of the leaves of Ipomoea pes-tigridis against liver HEPG2 Cell line. The leaves of Ipomoea pes-tigridis hydro alcoholic extract were tested for its inhibitory effect on HEPG2 Cell Line. The percentage viability of the cell line and the cytotoxicity activity of Ipomoea pes-tigridis against HEPG2 Cell line was carried out by using MTT assay method. Ipomoea pes-tigridis ethanolic extract has significant cytotoxicity effect on HEPG2 Cell Line in the concentration range at 500µg/mL produce 99.87% of cell inhibition. From the above performed assay, ethanolic extract of these drug shows greater activity on HEPG2 cell line that means Ipomoea pestigridis can be used as anticancer activity particularly for liver cancer REFERANCES 1. WHO, Diet, nutrition and the prevention of chronic diseases (world health organisation, technical report series), 916, WHO, Geneva 2003. 2. Ekin NL, A Hausa herbal pharmacopoeia: Biomedical evaluation of commonly used plant medicines, Journal of pharmacology, 1981:4,75-78. 3. Sanjay Patel, Niravgheewala, Ashok Suthar, Anand Shah. Invitro cytotoxicity activity of solanum extract against Hella Cell Line and Vero Cell line. International journal of pharmacy and pharmaceutical sciences, 2009:1, 1. 4. Zhong YZ. Review about mechanisms of anticancer of solanum nigrum. Zhongguo 2006; 15: 1225-6, 1260. 5.Prasanth NV , Dilip C, Sanaldev KT, Lisaugustine, Saraswathi R. Evalution of invitro cytotoxic and antioxidant activities of Ipomoea batatas. Int J Pharmacy& Pharm Sci 2010; 1(3). 6.Ramalingam R, Sivakumar T. Invitro and invivo anticancer activity of leaves of Plumeria alba Linn. J. Pharm. Res 2009; 2(2): 203-207. 7.PubMed Health www.ncbi.nlm.nih.gov. 8.Wikipedia, the free encyclopedia en.wikipedia.org/wiki/Hep_G 9.Matthew KM. The Flora of the Tamil Nadu Carnatic 1981; 2: 1017-1033. 10.Chopra RN, Nayar SL, Chopra IC. Glossary of Indian Medicinal Plants 1956: 141-142. 11.Sharma DP. Studies on nutritional qualities of Ipomoea pes-tigiridis Linn; a fodder plant from Kunvari Ravin land at Morena (MP) India. Asian J Chem 2002; 14(2): 1119-1121. 12.Hamsa TP, Kuttan G. Antioxidant activity of Ipomoea obscura. Amala Research Bulletin 2007; 27: 24-34. 13.Vimala Y, Elizabeth KM, Srilakshmi Selvi G. Antimicrobial activity of Ipomoea kentrochules on pathogenic microorganisms and microbial isolates on spoiled vegetables. Asian J Micro, Biotech & Environmental Sci 2007; (1): 41-44. 14.Khare AK, Srivastava MC, Tewa JP, Puri JN, Singh S, Ansari NA. A preliminary study of anti-inflammatory activity of Ipomoea turpethium (NISHOTH). Indian Drugs 1982; 19(6): 224-228. 15.Da Silvo Filho AA, Correa Lima RMO, De Andrade Chiapett A, Do Nascimento SC, De Souza IA, Demello JF, Veith HJ. Anticancer and antimicrobial glycosides from Ipomoea bahiensis. Phytochem 1986; 25(5): 1077-1081. 16.Navarro-Ruiz A, Delamora GP, Villanuev Michel MI, Dominguez JR, Bastidas-Ramirez BE, Quezada-Arellano JD, Rui Madrigal B. Anticonvulsant effect of aqueous, hydro alcohol and chloroform extracts from Ipomoea stans root in the rat. Phytotheraphy Res 1996; 10(3): 242-244. 17.Ferreria AA, Amarlal FA, Durate IDG, Oliveria PM, Alves RB, Silveria D, Azevedo AO, Raslan DS, Castro MSA. Antinociceptive effect from Ipomoea cairica extract. J Ethnopharmacol 2006; 105(1-2): 148-153. 18.Cordell GA. Phytochemistry 1995; 40: 1585-1612. 19.Harnburger M, Hostettmann K. Phytochemistry 1991;30: 3864-3874. 20.Kusumoto IT, Nakabayashi T, Kida H, Miyashiro h, Hattori M, Namba T, Shimotohna K. Screenung of various plant extracts used in ayurvedic medicine for inhibitory effects on human immune deficiency virus type I(HIV-I) protease. Phytotherapy Rearch 1995; 9: 180-184.

Medicinal plants are widely used by the traditional medical practitioners for curing various diseases in their day-to-day practice. Kharjura is one of the widely used drugs in Ayurveda. Its fruits are used in various diseases like Kshaya, Daha, Raktapitta, Murchha, Trishna, Shrama, Jwara, Swasa, Kasa, Madatyaya, etc. Present study highlights pharmacognostical difference between processed and fresh fruits of Kharjura. Pharmacognostical results revealed that the presence of loosely arranged mesocarp, etc in fresh Kharjura while spiral vessels, fiber with acicular crystals, saccharine and tannin content, etc. in processed Kharjura. REFERANCES [1] Morton JF, Miami FL. Date In: Fruits of warm climates, Puredue University Center for new crops and plant products; 1987:5-11. [1] Acharya Vidyadhar Shukla and Prof. Ravi Dutt Tripathi: Charaka Samhita, Sutra sthana, 4/40, Shramahara varg, Chaukhambha Sanskrit Sansthan, Reprint: 2010. [1] Bapalal Vaidhya: Nighantu Adarsh, Part-2, Page No. 1038, Gujarat Pustakalay Sahayak Sahakari Mandal Ltd.; Reprint: 1999. [1] Bapalal Vaidhya: Nighantu Adarsh, Part-2, Page No. 1038, Gujarat Pustakalay Sahayak Sahakari Mandal Ltd.; Reprint: 1999. [1] Bapalal Vaidhya: Nighantu Adarsh, Part-2, Page No. 1038, Gujarat Pustakalay Sahayak Sahakari Mandal Ltd.; Reprint: 1999. [1] Ahmad et al IJRAP, 4(3), May-June 2013 [1] Adel A. Kader and Awad M. Hussein: Harvesting and Postharvest Handling of Dates, International Center for Agricultural Research in the Dry Areas. [1] Khandelwal KR.: Practical Pharmacognosy,; Nirali Prakashan, Pune; 19th edition 2008. [1] Anonymous: The Ayurvdic Pharmacopoeia of India, Part-I, Vol.-IV, Govt. of India, Ministry of Health and Family Welfare, Department of I.S.M. & H, New Delhi; 1st edition 1999. Appendix 2. [1] Krishnamurty KV.: Methods in the plant histochemistry, Vishwanadhan Pvt. Limited, Madras; 1st edition 1988.

In this clinical study 66 Amavata (Rheumatoid arthritis) patients were registered from the O.P.D. & I.P.D. of the Institute of Post Graduate Ayurvedic Education and Research, Kolkata and 6 patients discontinued before completion of the treatment. In Group-A, 30 patients completed the treatment out of 34 and 4 patients left the treatment before completion of the course. The treatment schedule was Sneha pana (Orally intake of Ayurvedic medicated oil), Niragnik swedana (Sweating by without heat) and Virechan karma (Induced purgation by Ayurvedic procedure). In Group-B, 30 patients completed the treatment out of 32 and 2 patients left the treatment before completion of the course. The treatment schedule was Sneha pana (Orally intake of Ayurvedic medicated oil), Niragnik swedana (Sweating by without heat), Virechan karma (Induced purgation by Ayurvedic procedure) and Vardhaman Pippali Rasayan sevan (Rejuvenation with orally intake of Piper longum mature dried fruit powder in gradual increased and decreased dose). The aim of the study was comparative clinical evaluation between Group-A and Group-B in management of Amavata (Rheumatoid arthritis). In Group-A 60% and in Group-B 70% showed Major improvement. 40% in Group-A and 30% in Group-B showed Minor improvement. No-improvement and Complete remission was nil in both groups. No complication was found in this clinical study and Group-B was more effective management than Group-A. REFERANCES 1 Madhavakara, Rakshita V, Dutta S, Shastri S, Upadhyaya Y. Madhava Nidana (Madhukokosha Vyakya with Vidyotini Hindi Commentary), Ed 26, Part. I, Chaukhambha Sanskrit Sanathana, Varanasi, 1996, 460-464. 2 Harrison TR, Anthony S. Fauci et al. Harrison’s Principles of Internal Medicine, Ed 14, Vol. 2, McGraw Hill, New York, 1998, 1885. 3 Chakrapanidutta, Sengupta D, Sengupta U, Sensharma K, Bhattacharya S. Chakradutta, Amavata Chikitsa, Ed 1, Deepayan, Kolkata, 1999, 138-141. 4 Agnivesha, Charaka, Dridhbala, Nag B. Charaka Samhita, Chikitsa sthan, Pratham adyaya, Ed 1, Nabapatra, Kolkata, 1988, 27-28. 5 Harrison TR, Anthony S. Fauci et al. Harrison’s Principles of Internal Medicine, Ed 14, Vol. 2, McGraw Hill, New York, 1998, 1885. 6 Govindadas, Sengupta V, Sensharma K, Bhattacharya S. Bhaishaijya Ratnavali, Amavatadhikar, Tritiya khanda, Ed 1, Deepayan, Kolkata, 2000, 44-54. 7 Das D, Das A. Statistics in Biology and Physiology, Ed 4, Academic Publishers, Kolkata, 2005, 1-137.

Ayurveda describes the use of Kumari (Aloe vera Tourn. ex Linn., Liliaceae) for the management of different disease conditions in classical texts. In this article, an attempt has been made to compile as critically and its information related to Kumari from three samhitas, more than six samgraha granthas, and seven nighantus and other published texts. It is observed that root, leaves juice, extraction of Kumari are used as an ingredient in 267 formulations, which are effective in more than 41 disease conditions. The main indications include kushtha (skin disease), jwara (fever), kshaya (pulmonary tuberculosis), arsha (piles), vrana (wound), striroga (gynecological disorders), prameha (diabetes), pandu (jaundice), daha (burning sensation) etc., different parts of Kumari are used in about 12 dosage forms; such as kvatha (decoction), lepa (paste), avaleha (semi-solid preparations), taila (oil), ghrita (fat soluble preparations), vati (pills), churna (powder), rasa (mineral preparations) & nasya (nasal preparations). REFERANCES Anonymous. Ayurvedic Formulary of India. Part I, (CD ROM Version 1), Edn II, The Controller of Publication, Dept. of Ayush, Govt. of India, New Delhi, 2000. 2. Doshi Krunal, Acharya Rabinarayan. Therapeutic importance of Eranda (Ricinus communis Linn.) in Ayurveda - a Review. Ayurpharm Int J Ayur Alli Sci 2013; 2(9): 281-295. 3. D. S. Lucas. Dravyaguna-Vijnana. Edn 1st, Vol 2, Chaukhambha vishvabharati, Varanasi, 2008, 430. 4. Pandit Narahari. Raja Nighantu. Indradeo Tripathi, editor, Edn 3rd, Krishnadas Academy, Varanasi, 2003, 113. 5. Kaiyadeva. Kaiyadeva Nighantu. Sharma PV, Guru Prasad Sharma, editors, Edn 1st, Chaukhambha Orientalia, Varanasi, 1979, 648. 6. Bhavamishra. Bhavaprakasha Nighantu. Pandey GS, editor, Edn 1st, Chaukhambha Bharati Academy, Varanasi, 2006, 404. 7. Shaligram Vaishya. Shaligramanighantu Bhushanam. Edn 1st, Khemraj Shrikrishnadas Prakashan, Mumbai, 2002, 316. 8. Jayantilak JP. Sarasvati Nighantu. Kamat SD, editor, Edn 1st, Chaukhamba Sanskrit Pratishthan, Delhi, 2006, 55. 9. Sharma PV. Priyanighantu. Edn 1st, Chaukhambha Surbharti Prakashan, Varanasi, 2004, 104. 10. Bapalal Vaidya. Nighantu Adarsha. Edn II, Vol. 2, Chaukhambha Bharti Academy, Varanasi, 1999, 631. 11. Ibid 3. Dravyaguna-vijnana, 429. 12. J. L. N. Sastry. Ayurvedokta Oushadha niruktamala. Edn 1st, Chaukhambha Orientalia, Varanasi, 2001, 36. 13. Monier Williams. A Sanskrit English Dictionary. Bharatiya Granthh Niketan, New Delhi, 2007. 14. Vaman Shivram Apte. The Student’s Sanskrit-English Dictionary. 13th ed. Motilal Banarasidas Prakashan Private limited, Delhi, 2011. 15. Ibid 3. Dravyaguna-vijnana, 430. 16. Ibid 7. Sarasvati Nighantu, 55. 17. Ibid 6. Bhavaprakasha Nighantu, 404. 18. Ibid 4. Raj Nighantu, 114. 19. Sharangadhara. Sharangadhara Samhita. Srikanta Murthy KR, editor, Edn 4th, Chaukhambha Orientalia, Varanasi, 2001. 20. Vangasena. Vangasena Samhita. Saxena N, editor, Vol. I and II. Edn 1st, Chaukhamba Sanskrit Series office, Varanasi, 2004. 21. Rasavagbhata. Rasaratnasamuchchaya. Shastri AD, editor, Edn 3rd, Chaukhamba Orientalia, Varanasi, 1995. 22. Shadanand Sharma. Rasa Tarangini. Kashinath Shastri, editor, Edn 11th, Motilal banarasidas, Varansi, 2009. 23. Sri Gopal Krishna. Rasendrasarsangraha (Hindi). Satyartha P, editor, Edn 1st, Krishnadas Academy, Varanasi, 1992. 24. Acharya Dhundhuka Nath. Rasendrachintamani.Misra SN, editor, Edn 1st, Chaukhambha Orientalia, Varanasi, 2000. 25. Chakrapanidutta. Chakradutta. Indradev T, editor, Edn 4th, Chaukhamba Sanskrit Sansthan, Varanasi, 2002. 26. Tripathi ID, Tripathi DS. Yogaratnakar. Edn 1st, Krishnadas Academy, Varanasi, 1998. 27. Shri Govind Das. Bhaishajyaratnavali. Mishra BS, Shastri AD, Shastri RD, editors, Edn 19th, Chaukhmbha Prakashan, Varanasi, 2008. 28. Bharatbhaishajyaratnakara. Shah NC, editor, Vol. 1 to 5. Edn 1st, B Jain Publishers, New Delhi, 2005. 29. Bharatbhaishajyaratnakara. Shah NC, editor. Vol. 1 to 5. Edn 1st, B Jain Publishers, New Delhi, 2005. Vruhad nighantu ratnakar. 30. Bharatbhaishajyaratnakara. Shah NC, editor. Vol. 1 to 5. Edn 1st, B Jain Publishers, New Delhi, 2005. Rasa kamadhenu. 31. Bharatbhaishajyaratnakara. Shah NC, editor. Vol. 1 to 5. Edn 1st, B Jain Publishers, New Delhi, 2005. Gadanigrah. 32. Sharma PV. Dravyaguna Vijnana. Vol. II, Chaukhambha Bharti Academy, Varanasi, 2003, 449.

Background: Dushta Vrana (Chronic wounds) are frequently encountered problem in the present era produced due to the complications of trauma or pathological injury and it causes long-term agony to the patients. Chakradutt has mentioned the wound healing properties of Karanjadhya Ghrita. In the present study Karanjadhya Ghrita was prepared and its wound healing properties were studied on various chronic wounds. Methods: Karanjadhya Ghrita was prepared using the standardization procedure the effects were studied on 40 patients with chronic wounds (wounds more than 3 weeks old) selected from Outpatient and inpatient department of department of Shalya Tantra, National Institute of Ayurveda, Jaipur. The patients were divided into two groups – Group A (Karanjadhya Ghrita dressing) and Group B (Hydrogen peroxide and EUSOL and dry Gauze bandage). The drug was applied topically and patients were studied daily for 30 days and results were analyzed. Results: In Chronic Wound the size was decreased 69.23% which was statistically highly significant. There was considerable improvement (> 80 %) in swelling and unhealthy margin. Pain, tenderness, discharge and unhealthy granulation tissue showed moderate effect (between 60 to 70 percent) in the chronic wounds Conclusion: From the studies made from clinical cases, it was concluded that, the drug “Karanjadhya Ghrita” possess sufficient efficacy in Vrana Shodhan and Vrana Ropana properties without producing any adverse effects. The drug also increase the rate of contraction produces healthier granulation tissue and rapid healing time. Hence, this study conclude that application of Karanjadhya Ghrita is highly effective on chronic wounds. REFERANCES Sushruta “Sushrut Samhita” (1988) Commentory by Dalhanacharya Nibandha sangraha.Chaukhambha Orientalia Varanasi (2002) Sutra sthaana, Chapter-19. Tripathi Brahmanand, Charak Samhita – Charak Chandrika, Hindi Commentry Vol I and II, Chaukhamba Subharti Prakashan, Varanasi, reprinted, Charak Chikitsa, 25/24, 25, 83; 2003.p.840-41, 853. Shastri Sudarshan Madhav Nidana madhukosha-vidyotini, Hindi commentary, Uttaradha, Chukhamba Sanskrit Sansthan, Varanasi, Ch 42 (sharir vrana nidana); p 102. Vadiyaksabdasindhu, by Umesh Chandra Gupta, Chaukhamba Orientalia, Varanasi, 5th edition; 2005, p 553. Sushruta, Sushruta Samhita, Ayurveda Tatwa Sandeepika Hindi Commentry, edited by Kaviraj Ambika Dutta Shastri, Chikitsa Sthana, Dvivranayee Adhyaya – 1/3, Chukhamba Sanskrit Sansthan, Varanasi, Edition-11, 1997, p1. Sushruta, Sushruta Samhita, Ayurveda Tatwa Sandeepika Hindi Commentry, edited by Kaviraj Ambika Dutta Shastri, Chikitsa Sthana, Dvivranayee Adhyaya – 2/86-88, Chukhamba Sanskrit Sansthan, Varanasi, Edition-11, 1997, p26. Arana V, Paz Y, González A, Méndez V, Méndez JD (2004) Healing of diabetic foot ulcers in L-arginine-treated patients. Biomed Pharmacother 58: 588-597. Williams JZ, Barbul A (2003) Nutrition and wound healing. Surg Clin North Am 83: 571-596. Clark RA. Cutaneous Wound Repairs. In Goldsmith LA, editor. Physiology, Biochemistry and Molecular biology of skin. New York: Oxford University press; 1991.p576. Shastri A. Commentary Ayurveda Tatva Sandipika on Susruta Samhita of Sushruta, Chikitas Sthana. Dwivraniya Adhyaya. 12th ed., Ch. 1, Verse 55. Varanasi: Chaukhambha Sanskrita Sansthan; 2001. p. 8. Chakradutta Ratnaprbha Nischalkarkrat, edited by Acharya Priyavrat Sharma - Vranashoth Chikitsa 42/ 81-83, published by Swami Jayaramdas Ramprakash Trust, Jaipur, Edition 1, 1993. Sushruta Samhita Chikitsa Sthana, Ayurveda Tatwa Sandeepika Hindi Commentry, edited by Kaviraj Ambika Dutta Shastri, Ch 16/ 16-21. Chukhamba Sanskrit Sansthan, Varanasi, Vol I Edition Reprint 2009. Bhaisajya Ratnavali, Govinddas, Hindi Commentry by Ambika Dutt Shastri, Chapter Jwaradhikara 5/1285, Chaukhamba Sanskrit Sansthan, Varanasi, Edition 15th 2002. Prasad V, Dorle AK (2006) Evaluation of ghee based formulation for wound healing. J Ethnopharmacol 107: 38-47. Demling RH (2000) Oxandrolone, an anabolic steroid, enhances the healing of a cutaneous wound in the rat. Adv Skin Wound Care 8: 97-102. Database of Medicinal plants; Vol II, p 292; Vol III p 332, 561; Vol I p 152, 289, 394; Vol V, p 269. Hiremath SG. A Text Book of Bhaishajya Kalpana. 2nd revised ed. Part 1, Sneha Kalpana, Chapter 22, Varanasi: Chaukhamba Orientalia, 2005; 243.