Volume 5, Issue 4

Physico-chemical analysis provides the objective parameters to fix up the standards for quality of raw drugs as well as finished products. In the present study,Praval Mool is used as a Raw material to form Praval Bhasma. Praval (Coral) is the calcareous skeleton of the minute marine organism called Anthezoa polypus and belongs to phylum coelenterate.It is a natural source of rich calcium widely used in Amlapitta, Yakshma,Kasa, Netra Roga and Hridaya Roga and Ca deficiency diseases etc. it is administered in the form of Bhasma and Pisti. Moreover, in the market, it is available in two forms viz. Pravala shakha and Pravala moola. As in the market, moola is cheaper than shakha and has higher % of Calcium, shakha can be replaced by moola. Both are used for medicinal purposes. Shodhan of Praval is done in Sarjka kshara.The Pravala bhasma is prepared by triturating it with Godugdha and subjected to puta. The analytical procedures is carried out vide infra in two major headings incorporating physico-chemical tests like Total Ash, Acid Insoluble Ash, Loss on Drying, Particle Size, and advanced instrumental technics like XRD and XRF. REFERANCES 1.Yadavji. T:1998. Rasamritam DJ and GP. First Edition, Chaukhambha Sanskrit Bhawan,Varanasi . 2. Kaushal Arushi1 and Arora Ravinder International journal A comparative analytical study of Pravala bhasma and Pisti w.s.r. to Moola and Shakha 3. Agnivesh.1994:Charaka Samhita”, Chaukhmba orientalia.,Varanasi, Chikitsa Sthan – 1-1/58 . 4. Sadanand .1979 :Rasa Tarangini”, Motilal Banarasi Das., Varanasi, 23/139-141. 5. Sharma S. Rasatarangini. Varanasi: Motilal Banarsi Das.1979: 45-51. Indian. 6. Galib, Kar AC, Narayana A. Standardization of bhasmas need of the hour. J Ayurveda. 2008; 2: 27-33. 7. Mishra, LC, 2004: Scientific Bases for Ayurvedic Therapies. CRC Press, Washington DC, USA: pp 83-100. 8. Shastri Kashinath.editor. Rasatarangini of Sharma Sandnand .11th ed.New Delhi:Motilal publication;1979.p.627. 9. Tripathi YB. A multidisciplinary approach to standardize bhasmas (Ayurvedic metallic preparations). Curr Sci. 2006;90(7): 897-898. 10.Bhojashettar S, Jadar PG, Rao VN. Pharmaceutical study of Yashadabhasma. Anc Sci Life. 2012; 31(3): 90-94. 11). Gokhale S.B, Dr. C.K. Kokkate, A.P Purohit. A Text book of Pharmacognosy, 14th edition, Delhi, Nirali Prakashan, 2002, 1st Chapter, 58- 60pp. 12). Annonymous. The Ayurvedic Pharmacopoeia of India, 1st edition, New Delhi, Govt of India, Dept of Ayush, 2006, Part I, Vol 4, 213pp. 13). S.B. Gokhale, Dr. C.K. Kokkate, A.P Purohit, A Text book of Pharmacognosy, 14th edition, Delhi, Nirali Prakashan, 2002, 1st Chapter, 56pp. HY 14). Dr.K.Rama Chandra Reddy –Ocean of Ayurvedic Pharmaceutics,Chapter 29 Standardisation,First edition,Chaukhambha publication Pg.702. 15). www.google.com 16). S.Mahesh .Biotechnology-3including molecular biology, bio physics. new age international publishers, Delhi, part B, 9th chapter 282-284 pp. 17). Turner.R.A. analgesic in screening method cited in pharmacology edition turner or academic press London, New York, 1952, 110-117 pp. 18).www.wekipedia,com 19). www.rsic.iitm.ac.in

Asava & Arishta kalpana were originated from five basic kalpana swarasa and kwatha respectively. Though fermentation is the common process in them two nomenclature were denoted separately for these two by ancient acharya, this fact emphasize that these are not one and same. We can’t have clear difference in these two kalpana what exactly acharya expected as these two are intermingled terms. In this study literary as well as experimental difference between Asava & Arishta was studied. REFERANCES . Asavarista : Vigyayaum Zha, IIIrd Edition, Chaukhamba Bharati Academy, Varanasi. 2. Asava Vigyaniyam : Vd. Harisharnada, IInd Edition, The Punjab Ayurvedic Pharmacy Amritsar. 3. Astang Hrdaya (Sartha Vagbhata), Dr. Ganeshti Krishna Garde, Ist Edition, Anmol Prakashana, Pune. 4. Astang Samgraha : Comm by Vd. Pd. Lalachandra Shastri, IVth Edition, Shri Baidyanath Ayu. Bhavana Ltd., Nagpur. 5. Ayurvediya Ausdhikarana, Vaidyaka Grantha Bhandar, Pune Dhamankar 6. Ayurvediya Ausadhigunadharmasastra, Vaidyaka Grantha Bhandar, Pune. Gangadharasastri Gune. 7. Ayurveda Ka Vaiguanika Tihasa, Priyavata Sharma 8. Adulsa Mahausadhi, Arikush Kamble. 9 Bhaisajya Kalpnaa Vigyana, Acarya Siddhinanda Mishra, 4th Edition, Chaukhamba Bharati Prakasana. 10. Bhaisajya Kalpana Vigyanam, Dr. K. Rama Chandra Reddy, 1st Edition, Chaukhamba Sanskrita Bhavana, Varanasi. 11. Brhata Asavarista Samgraha : Kaviraj Shree Devasinhaji Vitthala, IInd Edition, Hindi Pustaka Agency, Gyanavyapi, Varanasi. 12. Bhaisajya Ratnavali : Kaviraj Shrre Ambikadatta Shasrti,XII Edition, Chaukhamba Sanskrita Sansthan, Banar 17. Bhesaja Kalpah : Vaidya Visardra V. S. Venkata Subramania Sastri central council for research in Indian Medicine and Homoeopathy, New Delhi. 18 A. Caraka Samhita : 18 B. Caraka Samhita : Yadavaji Trikamji Acarya : IV, Edition, Nimaya Sagar Press, Bombay. . 20. Dravya Guna Vigyana : Yadavaji Trikamaji Acarya, Chaukhamba Varanasi. 21. Dravya Guna Vigyana : Dr. P. V. Sharma, Chaukhamba, Varanasi. 22-a Gadunigraha : Chaukhamba Sanskrita Series, Varanasi. 23 Indian Medicinal Plants Chopra R. N. 24. Indian Materia Medica - Nadkarni, Popular Book Dept., Mumbai. . 29. Methods in Bio-statics, Dr. Mahajana B. M.,Jaypee Brothers, New Delhi. 30. Nighantu Adarsa : Vadya Bapulal G., Chaukhamba Bharati Academi, Varanasi. 31. Navaparibhasa : Kaviraj Upenndranath Das. 32. Principles and process of Pharmacy. 32-b Phyto chemical investigations of certain medicinal plants used in Ayurveda. (C. R. in Ayu. and Siddha,New Delhi). 34. Rasa Bhaisajya Kalpana Vigyana, Santosa Khandala, IInd Edition, Publication Scheme, Jaipur. 35. Sarangadhara Samhita : Acarya Ramkrishna Parashara, IV Edition, Baidyanath Ayu. Bhavan Ltd., Jhansi. 36. Susruta Samhita : with Nibandha Sangraha and Nyaya Candrika, VIth Edition, Chaukhamba Orientatil, Varanasi. 38. Text Book of Bio-chemistry : A. T. Cameron, 4th Edition, J&A Curchil Ltd.,. 39. Text book of Bhaisajya Kalpnaa : Shobha G. Hiremath, I.B.H. Prakashana, Banglore. 40. The Students Sanskrit English Dictionary :Vaman Shivaram Aple., Govt. of India. 41. Vacaspatyam : Shri Taranath, Trkavacaspati, Chaukhamba Sanskrit Series, Varanasi. 42. Wealth of India : Vol. 1-A, Publication and Information directorate, New Delhi. JOURNALS

The Nighantus, Ayurvedic form of Materia Medica could help significantly in this direction. Numerous Nighantus have been written from the very beginning of Ayurvedic period to solve the hidden meanings of cryptic names of medicinal plants. It is believed that at the end of each samhita a Nighantu was there. Indisputably the third millennium is witnessing the worldwide changes in healthcare. Ayurvedic system of healthcare has gained good popularity. Ayurveda is a profound and comprehensive system of health care that originated in India. This system endeavors to rationalize the all phenomena governing empirical experiences with natural products in medicine. Ayurvedic medicare system has attained popularity at global level to replace the synthetic chemicals as they have shown less adverse reactions. Plants have been one of the important sources of medicines since the beginning of human cultivation. There is a growing demand for plant based medicines, health products, pharmaceuticals, food supplements, cosmetics etc. Mulethi used as mild laxative, anti‐arthritic, antiinflammatory,anti‐biotic, anti‐viral, anti‐ulcer, memory stimulant (being MAOinhibitor), anti‐tussive, aphrodisiac, anti‐mycotic, estrogenic, anti‐oxidant, anti‐caries agent, anti‐neoplastic, anti‐cholinergic, anti‐diuretic, hypolipidemic agent. In this work a Nighantu of Sushruta named Sausruta Nighantu and another by Vagbhata the Astanga Nighantu are discussed. The present work aims to discuss Mulethi in various Nighantus as manuscripts or just as evidence - in a chronological order. REFERANCES · 1. Fan Y. G.; Shi Z. Q.; He B. L.; Extraction separation and application for glycyrrhizic and glycyrrhetic acid. Natural Product Research and Development. 1996, 8, 93‐99 2. Shibata S. Antitumor promoting and anti‐inflammatory activities of licorice principles and their modified compounds.Food Phytochemicals II: Teas, Spices and Herbs. 1994; 308‐321. 3. Yang L.; Liu Y. L.; Lin S. Q.; The determination of flavonoid in 6 kinds of licorice root by HPLC.Acta Pharmaceutics Sinica. 1990, 25, 840‐848 4. Dirsch V, Faculty of Life Sciences, Universitat Wien, 2006. 5. Setzer N, Natural Products Drug Discovery, 1999 6. Olukoga A, Donaldson D. Historical perspectives on health. The history of liquorice: the plant, its extract, cultivation, and commercialisation and etymology. J R Soc Health 1998; 118:300‐304. 7. Pt Hargovinda Shastri, Amaokosha of Amarsimha Chaukhambha Sanskrit Sansthan, Varanasi.2008, pp 190-191. 8. Sausruta, Sausruta Nighantu, edited by Kashiraja Sharma and Narendra Nath Tiwari; Pub. by Mahendra Sanskrit Vishvavidhalaya, Nepal, 1st Edition, 2001.pp.62-63 9. Vahata.Astanga Nighantu, Edited by P.V.Sharma, 1st Edition, Kuppuswamy Shastri Research Institute, Madras, , 1973, pp. 12-13 10. Dr. amrit Pal Singh, Dhanwantari Nighantu, Aamradi Varga, Puna, 1925. pp.167-168 11. Sodhala, Sodhala Nighantu ; Edited by Priya Vrit Sharma, Aamradi Varga, Oriental Institute, Baroda, 1st Edition 1978, pp 117, 287. 12. Bopadeva, Edited by Sharma P.V, Hridayadipaka Nighantu with Siddhamantraprakasa, Kaphavataghna varga, Chaukambha Amarabhārati, Varanasi, 1st Edition, 1977 pp.40-41. 13. Goli penchala Prashad, Edited by Vaidya P.S Shastri, Sadarsh Nighantu, Kashaya Dravya Skandh, Chaukhamba Sanskrit Series Office, Varanasi, 1st Edition, 2009, pp. 106,117. 14. Sharma PV, ; Madhava Dravyaguna, Vividha aushadhi varga, Chaukhamba Vedyabhavan, Varanasi, 1st Edition, 1973, pp.8-9 15. Nripamadanapala, Pt. Harihar Prashad Tripathi, ,Madanapala Nighantu, Vatadi Varga, Chaukhamba Krishnadas Academy, Varanasi, 2009, pp.132-133. 16. Kaiyadeva, Kaiyadeva Nighantu, Edited by P.V.Sharma and Guruprasad Sharma, Aushadhi varga, Chaukambha Orientatia, Varanasi, 1st Edition, 1979, pp. 180-181. 17. Late. Dr G.S. Pandey, Chunekar KC, Bhavmishra, Bhavaprakash Nighantu , , 6th edition, Chaukhambha Bharat Academy, Varanasi.1982 pg.506-507. 18. Sharma PV, Gunaratnamala; Edited By.Shri Bhav Mishra & Dr. Anurag Narain Singh, Vatadi Varga, Chaukhamba Sanskrit Bhawan, Varanasi, 1st Edition, 2006, pp.339-340. 19. Indradev Tripathi, Raj Nighantu, Acharya Vishwanath Durvedi, Aamradi Varga, Pub. Krishna Das Academy Varanasi 1982, pp.275-276. 20. Bapalal G vaidya, Nihantu adarsha, Pub. Chaukhamba Bharat academy 2007, Varanasi. 21. Sharma PV, Priya Nighantu, Haritakyadi varga, Chaukambha Surabharati Prakashana, Varanasi, 2004, pp.27-28 22. Olukoga A, Donaldson D. Historical perspectives on health. The history of liquorice: the plant, its extract, cultivation, and commercialisation and etymology. J R Soc Health 1998;118:300-304. 23. Ayurvedic pharmacopoeia of India Part-I vol.I, 168-169. 24. Indian Herbal Pharmacopoeia revised new edition 2002.Page 243, Warrier PK,NambiarVPK, and Ramakutty C.Indian medicinal plants:Orient Longman,Madras,1994:3(84) 25. V.K. Gupta et al. Antimicrobial potential of Glycyrrhiza glabra roots. Journal of Ethnopharmacology 116 (2008) 377–380.

Breast cancer is an increasing public health problem. In India breast cancer is the 2nd most common cancer after cancer cervix. Obesity and a sedentary lifestyle are two modifiable risk factors. Advances have been made in the treatment of breast cancer, but the introduction of methods to predict women at elevated risk and prevent the disease has been less successful. Plants have a long history of use in the treatment of cancer. In the recent years, a number of herbs have been found to possess anti-cancer potential. In the Unani system of medicine, breast cancer is described as warme sulabe pistan or sartane pistan. Unani physicians have mentioned in the texts that the warme sulab usually develops in the az’ae ratba. Various herbal formulations in Unani system of medicine have been used for the prevention. A number of herbal drugs such as rehan, mulaithi, methi, alsi etc are being researched and reviewed for their anti-cancerous properties. This review expands the concept of warme sulabe pistan in Unani system of medicine and anticancer effects and related mechanisms of some common natural herbs in the prevention of breast cancer. Details will be presented in full length paper along with scientific research. REFERANCES 1. Singh MM, Devi R, Walia I, Kumar R. Breast self examination for early detection of breast cancer. Indian J Med Sci 1999;53:120-6. 2. Anderson BO et al. (2008). Guideline implementation for breast healthcare in low-income and middle-income countries: overview of the Breast Health Global Initiative Global Summit 2007. Cancer, 113, 2221–43. 3. Smigal C, Jemal A, Ward E, etal. Trends in breast cancer by race and ethnicity: update 2006. CA Cancer J Clin 2006;56:168–183. 4. American Cancer Society. Breast Cancer Facts and Figures 2005–2006. Atlanta, GA: American Cancer Society; 2005. 5. Tabri AHBM. Al-moalijaate Buqraatiya. Part II, 1997. P 245 6. Kumar P, Malhotra N. Jeffcoate’s principles of gynecology. Jaypee brothers medical publishers; 2008. P.188. 7. Shahid U. Herbal Treatment Strategies for Breast Cancer. OMICS group of ebooks. 8. Martin C.Mahoney, Eleni Linos, Walter C, Willett. Opportunities and Strategies for Breast Cancer Prevention Through Risk Reduction. CA Cancer J Clin 2008;58:347–371 9. Sakarkar DM, Deshmukh VN. Ethnopharmacological Review of Traditional Medicinal Plants for Anticancer Activity. International Journal of PharmTech Research 3: 2011. 298-308. 10. Smith RA, Saslow D, Sawyer KA, Burke W, Costanza ME, Evans WP et al. American Cancer Society Guidelines for Breast Cancer Screening: Update 2003. CA Cancer J Clin 2003;53:141-169 11. Walter LC, Covinsky KE. Cancer screening in elderly patients: A framework for individualized decision making. JAMA 2001;285:2750-2756. 12. Walter LC, Brand RJ, Counsell SR. et al. Development and validation of a prognostic index for 1-year mortality in older adults after hospitalization. JAMA 2001;285:2987-2994. 13. Eccles SA, Aboagye EO, Ali S, Anderson AS, Armes JO, Berdetchevski F, Blaydes JP et al. Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast Cancer Research 2013, 15:R92. http://breast-cancer-research.com/content/15/5/R92. 14. Prentice RL, Caan B, Chlebowski RT, Patterson R, Kuller LH, Ockeene JK et al. Low fat dietary pattern and risk of invasive breast cancer: the woman’s health initiative randomized controlled dietary modification trial. JAMA 2006, 295: 629-642. 15. Fontein DB, De glas NA, Duijm M, Bastiamnet E, Portielje JE, Van de velde CJ. Age and the effect of physical activity on breast cancer survival: a systematic review. Cancer Treat Rev2013; 39:958-965. 16. Gullet NP, Rahul amin ARM, Bayraktar S, Pezzuto JM, Shin DM, Khuri FR et al. Cancer prevention with natural compounds. Seminars in Oncology. Vol 37. No 3. June 2010. pp 258-281 17. Ibne sina. Al-Qanoon. Jamia Hamdard. New Delhi, 1993. 18. Kitaabul umdah fil jarahat. Part I. Chapter 8. P. 169-170. 19. Kitaabul mukhtarat fit tib. P. 183 20. Ibne Sina AS. Al-Qanoon Fil-Tibb. Book I. Jamia Hamdard. New Delhi, 1993. 21. Kitaabul mukhtarat fittib. Part IV. P. 294. 22. Tabri AHBM. Al-moalijaate Buqraatiya. Part II, 1997. P. 245. 23. Ibne Sina. Al-qanoon. P. 1278-1279 24. Kitabul mukhtarat fittab. Part IV. P. 183. 25. Kitabul mukhtarat fittib. Part I.P. 294. 26. Al razi. HBZ. Kitabul hawi. P.16-27. 27. Qabeeruddin M. part II. Al-Akseer. P.1338-1339. 28. Ponnachan PT, Paulose CS, Panikkar KR. Effect of leaf extract of Aegle marmelose in diabetic rats. Indian journal of experimental biology.1993;31:345-347. 29. Subramanian S. Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats. Journal of Medicinal food.2004;7:61-66. 30. Gastric antiulcer effects of the leaves of the neem tree. Planta Medica. 1993; 59:215-7. 31. Umadevi M, Sampath KP, Bhowmik D, Duraive S. Traditionally Used Anticancer Herbs In India. Journal of Medicinal Plants Studies Year: 2013, Volume: 1, Issue: 3 First page: (56) Last page: (74) ISSN: 2320-3862. 32. Sairam K, Rao CV, Babu MD, Kumar VK, Goel RK. Antiulcerogenic effect of ethanolic extract of Emblica officinalis: an experimental study. J Ethnopharmacol. 2002;82:1-9. 33. Mahendran P, Vanisree AJ. The antiulcer activity of Gacinia cambogia extract against indomethacin induced gastric ulcer in rats. Phytotherapy research. 2002;16:80-83. 34. Lakshmi S, Padmaja G, Remani P. Antitumour Effects of Isocurcumenol Isolated from Curcuma zedoaria Rhizomes on Human and Murine Cancer Cells. International Journal of Medicinal Chemistry. 2011, 13. 35. Nadkarni AK. The Indian material medica. 1982. P 582 36. Shahid U. Herbal Treatment Strategies for Breast Cancer. October, 2013. www.esciencecentral.org/ebooks. 37. Winston JC. Health-promoting properties of common herbs. Am J Clin Nutr vol. ; 1999.70: 491-499. 38. Ji HD, Yasumasa I, Takaomi I, Hiroshi T, Hirotake K, et al. Glycyrrhizin enhances interleukin-12 production in peritoneal macrophages. Immunology 103; 2001. 235–243. 39. Itoh K, Kumagai K. Augmentation of NK activity by several anti-inflammatory agents. Excerpta Med 641; 1983. 460–464. 40. Chik W, Dalila W, Azura A, Parveen J. Purification and Cytotoxicity Assay of Tomato (Lycopersicum esculentum) Leaves Methanol Extract as Potential Anticancer Agent. Journal of Applied Sciences; 2010. 10. 32833288. 41. Son YO, Kim J, Lim JC, Chung Y, Chung GH, Lee JC. Ripe fruits of Solanum nigrum L. inhibit cell growth and induces apoptosis in MCF-7 cells. Food Chem Toxicol; 2003. 41. 1421–1428. 42. Rickard SE, Yuan YV, Thompson LU. Plasma insulin-like growth factor I levels in rats are reduced by dietary supplementation of flaxseed or its lignan secoisolariciresinol diglycoside. Cancer Lett 161; 2000. 47–55. 43. Zhang LY, Wang XL, Sun DX, et al. Regulation of zinc transporters by dietary flaxseed lignan in human breast cancer xenografts. Mol Biol Rep 35; 2008. 595–600. 44. Bergman Jungestrom M, Thompson LU, Dabrosin C. Flaxseed and its lignans inhibit estradiol-induced growth, angiogenesis, and secretion of vascular endothelial growth factor in human breast cancer xenografts in vivo. Clin Cancer Res 13; 2007. 1061–1067. 45. Winston JC.Health-promoting properties of common herbs. Am J Clin Nutr vol. 70; 1999. 491-499. 46. Sakarkar DM, Deshmukh VN. Ethnopharmacological Review of Traditional Medicinal Plants for Anticancer Activity. International Journal of PharmTech Research 3; 2011 298-308. 47. Belman S. Onion and garlic oils inhibit tumor promotion. Carcinogenesis 4; 1983 1063-1065. 48. Milner JA. Garlic: its anticarcinogenic and antitumorigenic properties. Nutr Rev 54: 1996. S82-86. 49. Nagabhushan M, Bhide SV. Curcumin as an inhibitor of cancer. J Am Coll Nutr 11; 1992. 192-198. 50. Winston JC. Health-promoting properties of common herbs. Am J Clin Nutr vol. 70; 1999. 491-499. 51. Sakarkar DM, Deshmukh VN. Ethnopharmacological Review of Traditional Medicinal Plants for Anticancer Activity. International Journal of PharmTech Research 3; 2011. 298-308. 52. Agarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res 23; 2003. 363-398. 53. Awale S, Lu J, Kalauni SK, Kurashima Y, Tezuka Y, et al. Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation. Cancer Res 66; 2006 1751-1757. 54. Gerlach SL, Rathinakumar R, Chakravarty G, Göransson U, Wimley WC, Darwin SP, Mondal D. Anticancer and chemosensitizing abilities of cycloviolacin 02 from Viola odorata and psyle cyclotides from Psychotria leptothyrsa, Biopolymers; 2010. 94. 617-25. 55. Kholoud K Khoja, Gowhar Shafi, Tarique N Hasan, Naveed Ahmed Syed, Abdrohman S Al-Khalifa, Abdullah H Al-Assaf, et al. Fenugreek, a Naturally Occurring Edible Spice, Kills MCF-7 Human Breast Cancer Cells via an Apoptotic Pathway. Asian pacific journal of cancer prevention. Volume 12; 2011. 56. Alkaabi AAA, Al-Falasi SA, Daoud S. Chemopreventive activities of Trigonella foenum graecum (Fenugreek) against breast cancer. Elsevier. Volume 29. Issue 8; 2005. 57. Kuo PL, Hsu YL, Cho CY. Plumbagin induces G2-M arrest and autophagy by inhibiting the AKT/mammalian target of rapamycin pathway in breast cancer cells. Mol Cancer Ther; 2006. 5(12). 3209

In majority women there are many problem in prakrut prasav so in these women we tried the experiment to rule out the role of ayurvedic remedy in prakrut prasava. Methods & findings – Madhu yashti & sahachar tail Anuvasana Basti was given to thirtyone patients in obs & gynac department from G.s. gune ayurved hospital ahmednagar. Tal & Dist ahmednagar maharashtra state india detected for prakrut prasava. Basti given at the eight days interval during ninth month of gestation. Conculsion – The drugs was found effective in treatment of prakrut prasava in 27 patient. In 3 patients drugs was not effective so L.s.c.s. done. Abbreviations – 1) Charak samhita 2) Vagbhata samhita 3) Sushruta samhita REFERANCES Vd. sou Jagtap P.S. M.S. (Stree Rog Prasuti Tantra) Lecturer stree rog prasuti tantra department G.S. gune ayurved college ahmednagar. 2) Vd Nalge P.S. M.D.(Sharir Rachana ) M.D. (Kayachikitsa) Ph.D Professor & H.O.D – Sharir rachana Dept. G.S. gune ayurved college Ahmednagar. 3) VD. Salgare U.V. M.D. sharir rachana. Associate professor – Sharir rachana Dept. G.S. gune ayurved college ahmednagar. 4) Vd. Bhavar V.R. M.D. ( Agadtantra) Lecturer & H.O.D Agadtantra Dept. G.S. gune ayurved college Ahmednagar. 5) Vd. Bhambare R.R. M.D. (Samhita) Lecturer Samhita Dept. G.S. gune ayurved college Ahmednagar.

The objectives of the present review article include to discus different aspects of Kushtha Roga (dermatological disorders in Ayurveda) i.e. etiopathogenesis, classification, clinical features and management etc. The authentic subject material has been reviewed from different Ayurveda literature. Different research and review article were searched in different journals. The subject material has also been searched on the internet. Kushtha is one of the most chronic disorders as described in Ayurveda. Most of the Ayurvedic texts categorise the Kushtha Roga into two groups, Mahakushtha and Kshudrakushtha which further divided in to seven types and eleven types respectively. Ayurveda described a wide range of etiological factors for dermatological disorders including its psychosocial aspect. Acharya Charaka, the author of foremost Ayurvedic classic on internal medicine, the Charaka Samhita clearly mentioned that there is a strong relationship exists between Tvacha (skin) and Mann (psyche/mind). Therefore, more than a cosmetic nuisance the skin disorders lead to different psychological ailments which impair the quality of life in the patients. The etio-pathogenesis involves the Sapta Dravya (seven factors), Vata, Pitta, Kapha, Tvacha, Rakta Mansa and Ambu/Lasika, which are responsible for manifestation of a wide range of dermatological disorders. Ayurvedic system of medicine described the psychosomatic approach of management for dermatological disorders including the pharmacological and non-pharmacological measures. REFERANCES 1. Singh Satyapal, Byadgi PS, Rai NP. Clinical evaluation of Virechan Therapy and Haridradi Vati and oil for the management of Kitibha Kushtha (psoriasis). Int. J. Res. Ayurveda Pharma. 2013, 4(2): 207-211. 2. Singh Satyapal, Tripathi JS, Rai NP. Preventive measures for dermatological disorders: An Ayurvedic perspective. World J Pharm Sci 2015; 3(3):678-681. 3. Dr. Singh Satyapal. Clinical study of Kitibha Kushtha (psoriasis) and its management with Samshodhan (Virechan) and Samshaman therapy. M.D. (Ay.) thesis. Banaras Hindu University: Varanasi, December 2010 4. Agnivesha, Charaka, Dridhabal. Charak Samhita, volume-2, Chaukambhabhaarti, academy, Varanasi, 2002, 248. 5. Sushurata. Sushruta Samhita, 14th edition,volume-1,Chaukhambha Sanskrit sansthan , Varanasi , 2003,250. 6. Agnivesha, Charaka, Dridhabal. Charak Samhita, volume-2, Chaukambhabhaarti, academy, Varanasi, 2002, 248. 7. Sushurata. Sushruta Samhita, 14th edition,volume-1,Chaukhambha Sanskrit sansthan , Varanasi , 2003,250. 8. Sushurata. Sushruta Samhita, 14th edition,volume-1,Chaukhambha Sanskrit sansthan , Varanasi , 2003,49. 9. Agnivesha, Charaka, Dridhabal. Charak Samhita, volume-1, Chaukambhabhaarti, academy, Varanasi, 2005, 706. 10. Agnivesha, Charaka ,Dridhabal. Charak Samhita, volume-1, Chaukambhabhaarti academy, Varanasi, 2005, 468. 11. Agnivesha, Charaka, Dridhabal. Charak Samhita, volume-1, Chaukambhabhaarti academy, Varanasi, 2005, 713. 12. Agnivesha, Charaka ,Dridhabal. Charak Samhita, volume-1, Chaukambhabhaarti academy, Varanasi, 2005, 713. 13. Agnivesha, Charaka ,Dridhabal. Charak Samhita, volume-1,Chaukambhabhaarti academy, Varanasi, 2005, 460. 14. Vagbhat. Ashtangahridaya ,Chaukhambha Sanskrit pratisthan, Delhi, 2003 , 432. 15. Agnivesha, Charaka ,Dridhabal. Charak Samhita, volume-1,Chaukambhabhaarti academy, Varanasi, 2005, 714. 16. Agnivesha, Charaka, Dridhabal. Charak Samhita, Sutra Sthan,Atreyabhadrakapiya addhyaaya -26/82,84, reprint, edited by Rajeshwar datta shashtri ji e.t al., Chaukambha bhaarti academy, Varanasi, 2005: 518. 17. Singh Satyapal, Tripathi JS, Rai NP. An integrated dietary approach for the management of dermatological disorders. Int. J. Res. Ayurveda Pharma. 2015[article in press]. 18. Agnivesha, Charaka, Dridhabal. Charak Samhita, volume-2, Chaukambhabhaarti, academy, Varanasi, 2002, 248. 19. Singh Satyapal, Tripathi JS, Rai NP, An overview of Ayurvedic & contemporary approaches to Psychodermatology. The Journal of Phytopharmacology 2014; 3(4): 286-299. 20. Sushurata. Sushruta Samhita, 14th edition,volume-1,Chaukhambha Sanskrit sansthan , Varanasi , 2003,251. 21. Agnivesha, Charaka ,Dridhabal. Charak Samhita, volume-1,Chaukambhabhaarti academy, Varanasi, 2005, 607. 22. Agnivesha, Charaka,Dridhabal. Charak Samhita, volume -2, Chaukambhabhaarti academy, Varanasi, 2005, 248. 23. Agnivesha, Charaka,Dridhabal. CharakSamhita, volume-1,Chaukambhabhaarti academy, Varanasi, 2005, 643. 24. Byadgi P S. Kushtha. Parameswarappa‘s Ayurvediya Vikriti Vigyan and Roga Vigyan, 1st edition, Volume II. Varanasi, Chaukhambha Sanskrit Sansthan, 2009; 268-98. 25. Sushurata. Sushruta Samhita, 14th edition,volume-1,Chaukhambha Sanskrit sansthan , Varanasi , 2003,246. 26. Singh Satyapal, Byadgi PS, Tripathi JS, Rai NP. Etiopathogenesis of Kushtha Roga W.S.R. to Psoriasis. Int. J. Pharm. Phytopharmacol. Res. 2015; 4 (5): 264-268. 27. Agnivesha, Charaka, Dridhabal. Charak Samhita, volume-1, Chaukambhabhaarti, academy, Varanasi, 2005, 642. 28. Agnivesha, Charaka, Dridhabal. Charak Samhita, volume-2, Chaukambhabhaarti, academy, Varanasi, 2002, 251-252. 29. Sushurata, Gayadas. Sushruta Samhita, 14th edition, volume-1,Chaukhambha Sanskrit sansthan , Varanasi , 2003,240. 30. Sushurata, Gayadas, Dalhan. Sushruta Samhita, 14th edition, volume-1,Chaukhambha Sanskrit sansthan , Varanasi , 2003,246. 31. Chakrapani, Agnivesha, Charaka, Dridhabal. Charak Samhita, volume-2, Chaukambhabhaarti, academy, Varanasi, 2005, 251-642. 32. Shashtri Lakshmipati. Yogratnakar. Uttarardha, Chaukhambha Prakashan, Varanasi, 2013, 215. 33. Madhavkar. Madhava nidana. Volume-2, chaukhambha sanskrita sansthan, Varanasi, 2003, 161. 34. Agnivesha, Charaka, Dridhabal. Charak Samhita, volume-2, Chaukambhabhaarti, academy, Varanasi, 2002, 252. 35. Sushurata. Sushruta Samhita, 14th edition,volume-1,Chaukhambha Sanskrit sansthan , Varanasi , 2003,248. 36. Madhavkar. Madhava nidana. Volume-2, chaukhambha sanskrita sansthan, Varanasi, 2003, 157-161. 37. Shashtri Lakshmipati. Yogratnakar. Uttarardha, Chaukhambha Prakashan, Varanasi, 2013, 215. 38. Agnivesha, Charaka, Dridhabal. Charak Samhita, volume-2, Chaukambhabhaarti, academy, Varanasi, 2002, 254. 39. Singh Satyapal, Tripathi , J.S., Rai, N.P.(2015). Critical appraisal of Virechan karma (therapeutic purgation) and it’s Bio-purificatory potential. Medha, international journal of multidisciplinary researches, IJMR 2015; 6(1-4): 59-67. 40. Dr. Singh Satyapal, Prof. Rai NP. Role of Samshaman Therapy In a Major Skin Disorder Kitibh Kushtha vis-à-vis Psoriasis. Shodh Drishti 2012; 3(7): 172-177. 41. Sushurata. Sushruta Samhita, 14th edition,volume-1,Chaukhambha Sanskrit sansthan , Varanasi , 2003,246. 42. Singh Satyapal. An Appraisal of Bio-Purificatory and Therapeutic Potential of Panchakarma. IJPRS 2015 (Article in press). 43. Singh Nishant. Panchakarma: Cleaning and Rejuvenation Therapy for Curing the Diseases. Journal of Pharmacognosy and Phytochemistry 2012; 1(2): 1-9. 44. Agnivesha, Charaka, Dridhabal. Charak Samhita, volume-2, Chaukambhabhaarti, academy, Varanasi, 2002, 258. 45. Singh S, Tripathi , JS, Rai, NP. A Review of Pharmacodynamic Properties of ‘Nishadi Vati’ - A Herbomineral Ayurvedic Formulation. IJPRS 2014; 3(2): 849-868. 46. Govind Das Sen. Bhaishajya Ratnavali. Chaukhambha Prakashan, Varanasi, 2008, 914. 47. Singh Satyapal, Tripathi JS, Rai NP, An overview of Ayurvedic & contemporary approaches to Psychodermatology. The Journal of Phytopharmacology 2014; 3(4): 286-299. 48. Sushurata. Sushruta Samhita, 14th edition,volume-1,Chaukhambha Sanskrit sansthan , Varanasi , 2003,248. 49. Singh Satyapal. Role Of Vihara (Ayurvedic Lifestyle) In The Prevention and Management of Dermatological Disorders. Int J Pharm Bio Sci 2015; 6(4): (B) 366 – 371. 50. Singh Anjana. A Short Review on ‘’Concept of Kshudraroga in Ayurveda’’ With Special Reference to Skin Diseases. IAMJ, 2014; 2(4): 483-489. 51. Sushurata. Sushruta Samhita, 14th edition,volume-1,Chaukhambha Sanskrit sansthan , Varanasi , 2003,49. 52.

Tulsi is very useful herb because of the wide range of properties it possesses. In addition to being considered as a holy plant, it is used for its medicinal values for thousands of years by the people all over the globe. The traditional healers use the plant for various ailments. In Ayurveda, tulsi is considered to pacify kapha-vata and vitiate pitta, and is used in the treatment of various disorders viz. respiratory tract diseases, fevers, eye diseases and depression. Recent research authenticates the claims of Ayurveda regarding pharmacological properties of the plant. Various studies conducted to study and establish the pharmacological properties of tulsi show that it has numerous pharmacological properties, many of which, like radioprotection and anticancer, can prove to be very important for the human race in this age of industrialization. REFERANCES Das SK and Vasudevan DM. Tulsi: The Indian holy power plant. Natural Product Radiance. 2006;5:279-83. Prajapati ND, Purohit SS, Sharma AK and Kumar T. A Hand Book of Medicinal Plant. Agrobios, India: 2003:367. Gupta SK, Prakash J and Srivastava S. Validation of traditional claim of Tulsi, Ocimum sanctum Linn. as a medicinal plant. Indian J Exp Biol. 2002;5:765-773. Biswas NP, Biswas AK. Evaluation of some leaf dusts as grain protectant against rice weevil Sitophilus oryzae (Linn.) Environ Ecol. 2005;23:485–8. Paranjpe Prakash. Indian Medicinal Plants. Chaukhamba Sanskrit Pratishthan, Delhi. 2005: 263. Sharma PC, Yelne MB and Dennis TJ. Database on Medicinal Plants used in Ayurveda, Vol. 1, Central Council for Research in Ayurveda and Siddha, New Delhi. 2001:500. Shukl V, Tripathi R D, Charak Samhita of Agnivesha Edn 2, Part I, Chaukhambha Sanskrit Pratishthan, Varanasi, 2000, 405. Ambikaduttshahtri , Susruta Samhita of Maharishi Sushruta, Edn 12, Part-I, Chaukhambha Sanskrit Sansthan, Varanasi, 2001, 203. Sharma PV, Sharma GP, Dhanvantri Nighantu, First Edition, Chaukhambha Orientalia Varanasi, 1982, 129. Dwivedi V, Bhav Prakash Nighantu 9th Edition, Motilal Banarasidass Delhi, 2007, 296. Sharma PV, Sharma GP, Kaiydev Nighantu First Edition, Chaukhambha Orientalia Varanasi, 1979, 633. Brahmanand Tripathi, Charak Samhita of Agnivesha Part II, Chaukhambha Surbharti Prakashan- Varanasi, 2001, 657. Durgadutt Shastri, Sharangdhar Samhita Chaukhambha Vidyabhavan Varanasi, 2002, 425. Shukl V, Tripathi R D, Charak Samhita of Agnivesha Edn 2, Part I, Chaukhambha Sanskrit Pratishthan, Varanasi, 2000, 381. The Ayurvedic Formulary of India Part 1. Controller of publications, Delhi. 2003. 20.29:268. Sidhinandan Mishra, Bhaishajyaratnavali, First Edition, Part-II, Chaukhambha Surbharti Prakashan- Varanasi, 2005, 2004-2005 The Ayurvedic Formulary of India Part 1. Controller of publications, Delhi. 2003. 12.21:189. Durgadatt Shastri, Sharangdhar Samhita, Chaukhambha Vidyabhavan Varanasi., 2002, 291. Agarwal P, Nagesh L, Murlikrishnan. Evaluation of the antimicrobial activity of various concentrations of Tulsi (Ocimum sanctum) extract against Streptococcus mutans: An in vitro study. Indian J Dent Res 2010;21:357-9. Prakash P, Gupta N. Therapeutic uses of Ocimum sanctum linn (Ocimum sanctum) with a note on eugenol and its pharmacological actions: A short review. Indian J Physiol Pharmacol 2005;49:125-31. Gupta D, Bhaskar DJ, Gupta RK, Karim B, Jain A, Singh R, et al. A randomized controlled clinical trial of Ocimum sanctum and chlorhexidine mouthwash on dental plaque and gingival infl ammation. J Ayurveda Integr Med 2014;5:109-16. Pattanayak P, Behera P, Das D, Panda SK. Ocimum sanctum Linn. A reservoir plant for therapeutic applications: An overview. Pharmacogn Rev 2010;4:95-105. Shokeen P, Bala M, Sing M, Tandon V. In vitro activity of eugenol, an active component from Ocimum sanctum, against multiresistant and susceptible strains of Neisseria gonorrhea. Int J Antimicrob Agents 2008;32:172-9. Mistry KS, Sanghvi Z, Parmar G, Shah S. The antimicrobial activity of Azadirachta indica, Mimusops elengi, Tinospora cardifolia, Ocimum sanctum and 2% chlorhexidine gluconate on common endodontic pathogens: An in vitro study. Eur J Dent 2014;8:172-7 Singh S, Malhotra M, Majumdar DK. Antibacterial activity of Ocimum sanctum L.fixed oil. Indian J Exp Biol. 2005;43:835–7. Geeta, Vasudevan DM, Kedlaya R, Deepa S, Ballal M. Activity of Ocimum sanctum (the traditional Indian medicinal plant) against the enteric pathogens. (472).Indian J Med Sci. 2001;55:434–8. Joshi CG, Magar N G Antibiotic activity of Indian Medicinal Plants, J Sci Ind Res 1952; 11B : 261 -263. Gupta K C, Vishwanathan. R. A short note on antitubercular substances from Ocimum sanctrum, Antibiotic Chemother. 1955 ; 25 : 22 – 23. Mahaprabhu R, Bhandarkar AG, Jangir BL, Rahangadale SP, Kurkure NV. Ameliorative effect of Ocimum sanctum on meloxicam induced toxicity in wistar rats. Toxicol Int 2011;18:130-6. Mandal S, Das DN, De K, Ray K, Roy G, Chaudhuri SB, et al. Ocimum sanctum Linn-a study on gastric ulceration and gastric secretion in rats. Indian J Physiol Pharmacol 1993;37:91-2. Parasuraman S, Balamurugan S, Christapher PV, Petchi RR, Yeng WY, Sujithra J, Vijaya C. Evaluation of Antidiabetic and Antihyperlipidemic Effects of Hydroalcoholic Extract of Leaves of Ocimum tenuiflorum (Lamiaceae) and Prediction of Biological Activity of its Phytoconstituents. Phcog Res 2015;7:156-65. Vats V, Grover JK & Rathi SS 2002 Evaluation of antihyperglycemic and hypoglycemic effect of T foenumgraecum, O sanctum and P marsupium in normal and alloxanized diabetic rats. Journal of Ethnopharmacology 79 95–100. J M A Hannan, L Marenah, L Ali, B Rokeya, P R Flatt and Y H A Abdel-Wahab 2006 Ocimum sanctum leaf extracts stimulate insulin secretion from perfused pancreas, isolated islets and clonal pancreatic beta cells. Journal of Endocrinology 189, 127–136. Asha Khanna, Poonam Shukla, Shajiya Tabassum 2011 Role of Ocimum sanctum as a Genoprotective Agent on Chlorpyrifos-Induced Genotoxicity. Toxicology International 18, 9-13. Uma Devi P, Ganasoundari A, Vrinda B, Srinivasan KK, Unnikrishnan MK. Radiation protection by the Ocimum flavonoids orientin and vicenin: Mechanism of action. Radiat Res 2000;154:455-60. Lahon K, Das S. Hepatoprotective activity of Ocimum sanctum alcoholic leaf extract against paracetamol-induced liver damage in Albino rats. Phcog Res 2011;3:13-8. Chattopadhyay RR, Sarkar SK, Ganguly S, Medda C, Basu TK. Hepatoprotective activity of Ocimum sanctum leaf extract against paracetamol induced hepatic damage in rats. Indian J Pharmacol 1992;24:163-5. Das SK, Vasudevan DM. Tulsi: The Indian holy power plant. Nat Prod Radiance 2006;5:279-83. Malve HO, Raut SB, Marathe PA, Rege NN. Effect of combination of Phyllanthus emblica, Tinospora cordifolia, and Ocimum sanctum on spatial learning and memory in rats. J Ayurveda Integr Med 2014;5:209-15. Bennadi SJ, Krishna KL. Protection of zonisamide induced memory impairment by tulsi extract and piracetam on mice. Int J Health Allied Sci 2014;3:170-6. Dokania M, Kishore K, Sharma PK. Effect of Ocimum sanctum extract on sodium nitrite-induced experimental amnesia in mice. Thai J Pharma Sci 2011;35:123-30. Kumar S, Rao S, Nayak S, Sareesh N. Effect of Ocimum sanctum (Linn) extract on restraint stress induced behavioral deficits in male wistar rats. Pharmacol Online 2007;3:394‑404. Sarahroodi S, Esmaeili S, Mikaili P, Hemmati Z, Saberi Y. The effects of green Ocimum basilicum hydroalcoholic extract on retention and retrieval of memory in mice. Ancient Sci Life 2012;31:185-9. M. Raghavendra, Rituparna Maiti, Shafalika Kumar, S. B. Acharya. Role of Ocimum sanctum in the experimental model of Alzheimer’s disease in rats. International Journal of Green Pharmacy 2009: 6-15. Singh S, Taneja M and Majumdar DK. Biological activities of Ocimum sanctum L. fixed oil- An overview. Indian J Exp Biol. 2007;45:403-412. Singh S, Rehan HMS and Majumdar DK. Effect of Ocimum sanctum fixed oil on blood pressure, blood clotting time and pentobarbitone-induced sleeping time. J Ethnopharmacol. 2001;78:139. Mahesh Subramanian, Gajanan J. Chintalwar, Subrata Chattopadhyay. Antioxidant and radioprotective properties of an Ocimum sanctum polysaccharide. Redox Report, Vol. 10, No. 5, 2005: 257-64. Vrinda B, Uma Devi P. Radiation protection of human lymphocyte chromosomes in vitro by orientin and vicenin. Mutat Res 2001; 498: 39-46. Sethi J, Yadav M, Sood S, Dahiya K and Singh V. Effect of tulsi (Ocimum Sanctum Linn.) on sperm count and reproductive hormones in male albino rabbits. Int J Ayurveda Res. 2010; 1(4): 208–210. Khanna S, Gupta SK, Grover JK. Effect of long term feeding of Tulsi (Ocimum Sanctum L) on reproductive performance of adult albino rats. Indian J Exp Biol. 1986;24:302–4. Reghunandanan R, Sood S, Reghunandanan V, Mehta R M, Singh G P. Effect of ocimum sanctum linn (tulsi) extract on testicular function. Indian J Med Sci 1995;49:83-7. Bhartiya US, Raut YS, Joseph LJ. Protective effect of Ocimum sanctum L after high-dose 131iodine exposure in mice: An in-vivo study. Indian J Exp Biol. 2006; 44:647-52. Kim SC, Magesh V, Jeong SJ, Lee HJ, Ahn KS, Lee HJ, et al. Ethanol extract of Ocimum sanctum exerts anti-metastatic activity through inactivation of matrix metalloproteinase-9 and enhancement of antioxidant enzymes. Food Chem Toxicol 2010; 48:1478-82. P. Sharma, S. Kulshreshtha, A.L. Sharma. Anti-cataract activity of Ocimum sanctum on experimental cataract. Indian Journal of Pharmacology 1998; 30: 16-20. Harman D. Free radical theory of ageing. J Gerontol. 1971;266:451-6. Srivastava A, Agarwal R, Chaturvedi TP, Chandra A, Singh OP. Clinical evaluation of the role of tulsi and turmeric in the management of oral submucous fibrosis: A pilot, prospective observational study. J Ayurveda Integr Med 2015;6:45-9.

10 % of the world population suffer from sterility. 80 % of the couples achieve conception if they then desire, within one year of having regular intercourse with adequate frequency. Infertility is a failure to conceive within one or more years of regular unprotected coitus. Infertility is the social stigma in our country, particularly in urban areas, which affects the couples psychological harmony, sexual life and socialfunctioning. Male infertility has got less attention, even though it is widely described. According to a population study, in 30% of the infertile couples problem lies for males.The most common reason for infertility in male is the inability to produce adequate number of healthy sperms leading to oligospermia. Ksheenashukra is one of the major variety of shukradosha, explained in ayurveda.In ksheenashukra there is diminished level of shukra both quantitatively and qualitatively which ultimately leads to childless couples.In ayurvedic text, many herbal preparations mentioned in management of ksheenashukra.Bala-tail Utterbasti said to be vrushya, hence can be considered as ideal treatment for shukradosha.This present study is intended, to clinical evaluation of action Bala-tail Utterbasti in oligospermia. Currently several modern medical therapies along with surgeries are available to overcome this disorder causing mental and social discomfort. The case study included Oligospermia; the objective of present study was to evaluate the efficacy and safety of the Bala-tail Utterbasti (i.e.insertion of oil-based medicine through urethra into the bladder cavity). Uttar basti has an ancient medical reference of renowned ayurvedic surgeon ‘Sushruta’ in his text Sushrut Samhita Sharirstan2/10.In reference with this context, a clinical study using Bala-tail Utterbasti was performed to evaluate its efficacy in infertility disorders REFERANCES Acharya Priyavrata Sharma, editors. Charaka Samhita of Agnivesa.Vol.2, 6th Edition 2000. Chaukhambha Sanskrit Sanstan Varanasi, Page.no.769to771, Vonivyapad Chiksadhya-30. 2. Prof.J.K.Ojha, editor, A Hand Book of Dravyaguna.1st.ed.Sanskrit Pratishthan. vanaspatika Dravya Varanasi, Chaukhamba 2004 page no.45and346 3. Premavati Tivari, editor. Ayurvediya Prasutitantra Evam Striroga.2nd ed. Chaukhambha Orientalia, Varanasi, 2nd part- page478-496. 4 T.N. A.Jeffcoate, editor.Principles of Gynaecology.3rd.London. Butterworth & co. Ltd Publication, 1967, Page no. 749-751. 5. Sushrut Samhita Sarirsthanam by Bhaskar Govind Ghanekar, Published by Meharchand LachhmandasPublication, reprint-March2006 New Delhi.Page no.23, 2/10. 6. Stri.Nagindas Chhaganlal Shah Sangrahit Bharatbhaishajya Ratnakar, 3rd part-Page no.585 (4681).Reprint2005Prakashak B.Jain Publication (Pvt.Ltd) New Delhi.

Thyroid gland is one of the important glands of the endocrine system. Principal function of thyroid gland is to act as a ‘catalyst’ for the maintenance of oxidative metabolism. Hypothyroidism is the most common endocrine disorder observed all over the world in present time. It occurs about 7-8 times more frequently in females than males. In infants, symptoms do not appear till six months because enough hormone is present in mother’s milk. It affects the quality of life of individuals. The only treatment available is synthetic thyroxine tablets which patients had to take lifelong. Agni is the unique concept of Ayurveda related to Pachana or conversion, Dhatupaka or Metabolism, etc. i.e. various chemical reactions occurring in the body. It is responsible for and controls each and every process of conversion. The normal as well as abnormal functions of thyroid gland can be correlated to healthy and altered status of Agni. So hypothyroidism can be considered as a stage of Agnimandya resulting in the formation of Ama. REFERANCES · 11. 2. Isselbacher KJ, Braunwald E, Wilson JD, Martin JB, Harrison’s Principles of Internal Medicine. 17th edition, United States of America, RR Donnely & Sons company. 2000. Vol 2 Page 2224. 3. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169866/ 4. Stanley Davidson. In: Colledge NR, Waller BR, Ralston SH, (eds.) Davidson’s Principles and Practice of Medicine. 16th edi. U.K.: Churchill Livingstone Elsevier; 2010. Page 741. 5. Krupp MA, Chatton MJ, Werdegar D. In: (eds.) Current medical diagnosis & treatment 1985. 1st edi. Singapore: Lange medical publications, USA; 1985. Page 703. 6. http://www.thyroidindia.com/docs/thyroid_disorder_medical.php 7. Sushruta Samhita, Edited by Dr. Ambikadatt Shastri, Chaukhambha Sanskrit Samsthan, Varanasi, 9th Edition, 2051 Sutrasthana, Aaturopkramaniya Adhyaya, 35/32. Page no. 167 8. Ashtanga Hridaya, Edited by Dr. Anna Moreshwar Kunte, Chaukhambha Surbharati Prakashan, Varanasi, Reprint Edition, 2002 SutraSthana, Doshopakramniya Adhyaya, 13/25. Page no. 216 9. Charaka Samhita, Edited by Dr.Brahmanand Tripathi, Chaukhambha Surbharati Prakashan, Varanasi, Reprint Edition 2009 Chikitsa Sthana, Gahani Dosha Chikitsa Adhyaya, 15/42,43. Page no. 559 10. Ashtanga Hridaya, Edited by Dr. Anna Moreshwar Kunte, Chaukhambha Surbharati Prakashan, Varanasi, Reprint Edition, 2002 SutraSthana, Doshopakramniya Adhyaya, 13/23,24. Page no. 216 11. Ashtanga Hridaya, Edited by Dr. Anna Moreshwar Kunte, Chaukhambha Surbharati Prakashan, Varanasi, Reprint Edition, 2002 SutraSthana, Doshopakramniya Adhyaya, 13/28,29. Page no. 217 12. Charaka Samhita, Edited by Dr.Brahmanand Tripathi, Chaukhambha Surbharati Prakashan, Varanasi, Reprint Edition 2009 Sutra Sthana, Maharoga Adhyaya, 20/17. Page no. 395 13. Sushruta Samhita, Edited by Dr. Ambikadatt Shastri, Chaukhambha Sanskrit Samsthan, Varanasi, 9th Edition, 2051 Sharira Sthana, Garbhavyakaran Sharir Adhyaya, 4/4. Page no. 37 14. Charaka Samhita, Edited by Dr.Brahmanand Tripathi, Chaukhambha Surbharati Prakashan, Varanasi, Reprint Edition 2009 Chikitsa Sthana, Swayathuchikitsa Adhyaya, 12/79. Page no. 459 15. Sushruta Samhita, Edited by Dr. Ambikadatt Shastri, Chaukhambha Sanskrit Samsthan, Varanasi, 9th Edition, 2051 Nidana Sthana, Granthyapachyarbudagalgandanam Adhyaya, 11/29. Page no. 356 16. Vridha Jiwak Tantra, Kasyapa Samhita, Edited by Proff. P.V. Tiwari, Chaukhambha Vishwabharti, Varanasi, 1st Edition, 1996 Khil Sthana,25/10. Page no. 387

Diabetes Mellitus refers to a group of common metabolic disorders that share the phenotype of hyperglycemia. Several distinct types of DM are caused by a complex interaction of genetics and environmental factors. Depending on the aetiology of the DM factors contributing to hyperglycemia include reduced insulin secretion, decreased glucose utilization, and increased glucose production. The Virecana Karma (cellular biopurificatory measures) of Ayurveda is claimed to produce cellular cleansing effect, promoting mobilization of essential nutritional pool and immune enhancing effect. Such a line of management is preferred in Ayurveda because of Srotodusti and accumulation of metabolic waste products (Àma) are the main culprit in the diathesis of disease, which is of great significance in case of type-2 Diabetes mellitus. Considering this fact, the present study had been under taken to conduct clinical assessment of the role of Virecana Karma (shodhan Therapy) & Ayaskriti(Samana Therapy) in cases of type 2 diadetes. During this study it was found that only with the help of complete ayurvedic measures i.e Samsodhan & Samana measure (Virecana karma & Ayaskriti) there was fall in Blood sugar level in Type-2 DM as well as lipid profile & clinical symptoms were also improved. REFERANCES · 1. Harrison’s : Principle of Internal Medicine, edited by Eugene Braunwald, Stephen L. Hauser, Anthony S. Fauci, Dan L. Longo, Dennis L. Kasper, J. Larry Jameson. Mc.GrawHill – Medical Publishing Division, 18th edi. 2. API Textbook of Medicine edited by Siddharth N. Shah, Publised by The Association of Physiations of India, 7th edi., revised reprint 2006. 3. Astanga Hridaya of Vagbhata with commentaries Sarvangasundra of Arundatta and Ayurveda Rasayana of Hemadri, Chowkhamba Prakashan, Varanasi, 1997. 4. Astanga Hridaya, edited by Prof. K.R. Srikantha Murty, Krishnadas Academy, Varanasi, IIIrd edi., 2000 5. Dravya Guna Vijana by P.V. Sharma, Vol II, Chowkhamba Sanskrit Sansthan, 7th edi. 1999. 6. Sushruta Samhita edited by Prof. P.V. Sharma, Chaukhamba Vishwabharati, Varanasi, Istedi.,2001. 7. Charaka Samhita edited by Vaidya Jadavaji, Trikamji Acharya, , Chaukhamba Surbharati Prakashan, Varanasi Reprint edition, 1992.

The Unani medicine is based upon the concept of Mizaj (Temperament). The temperament (mizaj) of an individual being a dynamic state varies under different physiological conditions such as age, sex, environment, etc. The entire span of life is divided into four phases; sin-al-namu (the period of growth and development extends from birth of the child up to the age of thirty years), sin-al-shububiyah or sin-al-waquf (manhood extends from thirty to forty years), sin-al-kuhulah (Aetus verelis extends from forty to sixty years) and sin-al-shaykhukhah (old age or Aetus cripita). The mizaj of sin-al-namu is hot and moist, sin-al-waquf is hot and dry, sin-al-kuhulah is cold and dry and of sin-al-shaykhukhah is also cold and dry. It has been also mentioned that during sine kuhulat production of sauda increases and its mizaj is cold and dry. According to the classification of age in Unani medicine, the menopausal age group comes under sine kuhulat so menopausal women are more prone to develop saudavi diseases like carcinoma, melancholia, depression, insanity which are common in this age. So all those methods which has been mentioned in Unani literature to correct the mizaj and prevent the ghalbae (excess) sauda will be beneficial in postmenopausal symptoms as well as in preventing the development of carcinoma. REFERANCES · 1. Zaidi IH. Kulliyat-e-Umoor-e-Tabi’yah 1stedn. Aligarh; Litho Offset Printers. 2011: 35,48,77,78. 2. Ahmed HSI. Al-Umoor Al-Tabiyah (Principles of Human Physiology in Tibb). 1stedn. CCRUM 2009: 44,129,133,135. 3. Masihi ASIYI. Kitab-al Mata. (Urdu translation) Vol I. New Delhi; CCRUM 2008: 107,179. 4. Mushtaq S. Post-menopausal Women: A Study of Their Psycho-physical Changes with an Impact on Family. Anthropologist, 2011; 13(2): 131-135. 5. Shah MH. The General Principles of Avicenna’s Canon of Medicine. New Delhi; Idara Kitab-ul-Shifa. 2007: 229. 6. Jurjani AH. Zakhirah Khwarzam Shahi (Urdu translation). New Delhi; Idara Kitabushifa. 2010: 590. 7. Dashti Z, Shariatifar N, Nafchi AM. Study on antibacterial and antioxidant activity of Berberis vulgaris aqueous extracts from Iran. International Journal of Pharma Sciences and Research 2014; 5(10): 705-708. 8. Baravalia Y, Kaneria M, Vaghasiya Y, Parekh J, Chanda S. Antioxidant and Antibacterial Activity of Diospyros ebenum Roxb. Leaf Extracts. Turk J Biol 2009; 33: 159-164. 9. Stoilova IS, Wanner J, Jirovetz L, Trifonova D, Krastev L, Stoyanova AS, et al. Bulgarian Journal of Agricultural Science 2014; 20(2): 227-237. 10. Baroš S, Karšayová M, Jomová K, Gáspár A, Valko M. Free Radical Scavenging Capacity of Papaver somniferum L. And Determination of Pharmacologically Active Alkaloids Using Capillary Electrophoresis. JMBFS 2012; 1: 725-732. 11. Haniya AMK, Padma PR. Antioxidant potential of Artemisia vulgaris, L. Leaves. WJPPS 2013; 3(1): 654-660. 12. Agarwal K, Chakarborthy GS. In Vitro Antioxidant Activity of Different Extract of Bark of Juglans Regia. International Journal of Innovative Pharmaceutical Research 2012; 3(1): 199-202. 13.Shakir KAF, Madhusudhan B. Effects of Flaxseed (Linum usitatissimum) Chutney on GAMMA-Glutamyl Transpeptidase and Micronuclei Profile in Azoxymethane Treated Rats. Indian Journal of Clinical Biochemistry 2007; 22 (2): 129-131. 14. Shukla V, Vashistha M, Singh SN. Evaluation of Antioxidant Profile and Activity of Amalaki (Emblica officinalis), Spirulina and Wheat grass. Indian Journal of Clinical Biochemistry 2009; 24(1): 70-75 15. Murali A, Ashok P, Madhavan V. Antioxidant activity of leaf of Hemidesmus indicus (L.) R.Br. var. pubescens (W. & A.) Hk.f. (Periplocaceae)-an in vivo analysis. Spatula DD. 2011; 1(2): 91-100. 16. Shiban MS, Al-Otaibi MM, Al-Zoreky NS. Antioxidant Activity of Pomegranate (Punica granatum L.) Fruit Peels. Food and Nutrition Sciences 2012; 3: 991-996. 17. Rajeshwari CU, Abirami M, Andallu B. In Vitro and In Vivo Antioxidant Potential of Aniseeds (Pimpinella anisum). ASIAN J. EXP. BIOL. SCI. 2011; 2(1): 80-89. 18. Munir N, Ijaz W, Altaf I, Naz S. Evaluation of antifungal and antioxidant potential of two medicinal plants: Aconitum heterophyllum and Polygonum bistorta. Asian Pac J Trop Biomed 2014; 4(2): 639-643. 19. Doorika P, Ananthi T. Antioxidant and Hepatoprotective properties of Terminalia arjuna Bark on Isoniazid Induced Toxicity in Albino rats. Asian J. Pharm. Tech. 2012; 2(1): 15-18. 20. Shahriar M, Hossain MI, Sharmin FA, Akhter S, Haque MA, Bhuiyan MA. InVitro Antioxidant and Free Radical Scavenging Activity of Withania Somnifera Root. Iosr Journal of Pharmacy 2013; 3(2): 38-47. 21. Panchawat S, Sisodia SS. In vitro Antioxidant Activity of Saraca asoca Roxb. De wilde stem bark extracts from various extraction processes. Asian Journal of Pharmaceutical and Clinical Research 2010; 3(3): 231-233. 22. Sundaram R, Mitra SK. Antioxidant activity of ethyl acetate soluble fraction of Acacia Arabica bark in rats. Indian J. Pharmacol 2007; 39(1): 33-38. 23. Koksal E, Bursal E, Dikici E, Tozoglu F, Gulcin I. Antioxidant activity of Melissa officinalis leaves. Journal of Medicinal Plants Research 2011; 5(2): 217-222. 24. Rajan S, Gokila M, Jency P, Brindha P, Sujatha RK. Antioxidant and Phytochemical Properties of Aegle marmelos Fruit pulp. Int J Curr Pharm Res 2011; 3(2): 65-70. 25. Hazra B, Sarkar R, Biswas S, Mandal N. RCesoeamrchp artaicrleative study of the antioxidant and reactive oxygen species scavenging properties in the extracts of the fruits of Terminalia chebula, Terminalia belerica and Emblica officinalis. BMC Complementary and Alternative Medicine 2010; 10:20. 26. Keser S, Celik S, Turkoglu S, Yilmaz O, Turkoglu I. Antioxidant Activity, Total Phenolic and Flavonoid Content of Water and Ethanol Extracts From Achillea millefolium L. Turk J Pharm Sci 2013; 10 (3): 385-392. 27. Swati, Bedi S, Tanuja. In Vitro antioxidant potential and phytochemical screening of Eclipta alba. Asian J.EXP.BIOL.SCI.2012; 3(4): 785-789. 28. Beaulah AG, Sadiq MA, Santhi JR. Antioxidant and antibacterial activity of Achyranthes aspera : An in vitro study. Annals of Biological Research 2011; 2(5): 662-670. 29. Kumar SS, Felicia C. In vitro Antioxidant Activity on the Root Tuber of Smilax china L. Int J Pharm Bio Sci 2015; 6(1): 421-426. 30. Varalakshmi B, Vijaya anandh A, Vijayakumar K, Prasanna R. In vitro Antioxidant Activity of cinnamomum zeylanicum Linn Bark. International Journal of Institutional Pharmacy and Life Sciences 2012; 2(3): 154-166. 31. Ibn Rushd AWM. Kitab al Kulliyat (Urdu translation). New Delhi; CCRUM 1987: 360-361. 32. Qureshi HEH. Ilaj bazariye ghiza. New Delhi; Qaumi Council Baraye Farogh Urdu Zaban 1999: 27,45. 33. Bughdadi AAA. Kitab-al Mukhtarat fil tib (Urdu translation) part I. New Delhi; CCRUM 2005: 191,207,208. 34. Hamdani SKH. Usool-e-Tibb. 1st edn. New Delhi; Qaumi Council Baraye Farogh Urdu Zaban 2011: 46,56.

Choorna of several varieties of a single or more herbs is the choice of almost all Ayurvedic physicians. The method of preparation of Choorna is the discretion of physician or pharmacists. A standard method is not formulated till today for the preparation of Choorna. We propose a plan of study for standardization in preparation of Choorna. For the same purpose Atibala is preferred because the shrub is easily available in our area. All parts of it are to be studied for choorna. It grows full in less than three months time, it is flowering throughout the year. In this study albino rat is preferred for experiments REFERANCES · 1. CharakaSamhitha( SutraSthana) 22nd Chapter. 2. AstangaSangraha, (Sutra athana) 24th Chapter. 3. Dalhana Acharya on SusrutaSamhitha, Sutra - 46/5-8 4. Kunjalalk..Su. Sam. Su. – 1, 37 – 5 1991 Chaw, books Varanasi. 5. Raja Nighantu, chap. 2/6. 6. Sarangadhara part – 1, chap 1-59 7. GovindakarR ..MateraiMedica 8. YadhavaJiThrikamaji – DravyaGunaVighnana, PrathamaParibhasha 9. Mishra B. S.,VaishyaR..Bhavaprakasha part – 1 Bhe. Vid. Pra – II – 815, 1994 Chaw. Books - Delhi

Tuberculosis is the main cause of morbidity in modern era and came to existence many decades ago and has emerged as pandemic disease. The use of allopathic medicine in complex disease like tuberculosis is associated with the problem of cross resistance and herbal drugs (medperuomo.com) have proven to be most effective in this context. The exploration of therapies for the successful attenuation of the morbid condition associated with tuberculosis is the need of the day. REFERANCES · 1. Sam Burcher and Mae-Wan Ho,1996. Prac. Global strategy for traditional medicine research: 142-144 2. Zink A, Sola C, Reischl U, Grabner W, Rastogi N, Wolf H, Nerlich A (2003). "Characterization of Mycobacterium tuberculosis Complex DNAs from Egyptian Mummies by Spoligotyping". J Clin Microbiol 41 (1): 359–67. doi:10.1128/ JCM.41.1.359-367.2003. PMC 149558. PMID 12517873. 3. Koju D, Rao BS, Shrestha B, Shakya R, Makaju R. ‘‘Occurrence of side effects from antituberculosis drugs in urban nepalese population under dots treatment’’. Kathmandu university journal of science, engineering and technology 2005; 1(1). 4. Abbruzzese, M.R.,Delaha, E.C.,Garagusi, V.F.,1987. Absence of antimyco bacterial synergism between garlic extract and antituberculosis drugs. Diag. Microbiol. Infect. Dis.; 8(2): 79-85. 5. Gabbrielli, G., Loggini, F., Cioni, P.L., Giannaccini, B., Mancuso, E. 1988. Activity of lavandino essential oil against non-tubercular opportunistic rapid grown mycobacteria. Pharmacol. Res. Commun.; 20 Suppl. 5:37-40. 6. Ma, T.S. and Roper, R., 1968. Microchemical investigation of medicinal plants, I. The antitubercular principle in Prunus mume and Schizandra chinensis.Mikrochim.Acta.;167-181. 7. Ghosal, S. and Chaudhuri, R.K., 1975. chemical constituents of Gentianaceae XVI; antitubercular activity of xanthones of Canscora decussate Schult. J. Pharm. Sci.; 64: 888-889. 8. Glasby, S., 1976. Encylopedia of Antibiotics, Wiley, London. Pp. 352. 9. Gupta, O.P., Amarnath, Gupta, S.C. and Srivastava, T.N. 1980. Preparation of semi- synthetic analogues of Piper amides and their antitubercular activity. Bull. Med. Ethnobot. Res.; 1(1): 99-106. 10. Ghosh S, Malik SK, Gupta A, Chaudhary R. ‘‘Aprospective, observational cohort study to elicit adverse effects of anti-tuberculosis drugs among patient treated for active tuberculosis’’. The Pharma Research (T. Ph. Res.) 2010; 3: 10-16. 11. Nahar BL, Mosharrof Hossain AKM, Islam MM and Saha DR. ‘‘A comparative study on the adverse effects of two anti-tuberculosis drugs regimen in initial two-month treatment period’’. Bangladesh J Pharmacol 2006; 1: 51-57. 12. Sehlapelo BM, Drewes SE, Scott-Shaw R. ‘‘A 6-substituted 5,6-dihydro-α-pyrone from two species of Cryptocarya’’. The International Journal of Plant Biochemistry 1994; 37(3): 847- 849. 13. Bapela MJ, Lall N, Isaza-Martinez JH, Regnier T, Meyer JJM. ‘‘Variation in the content of naphthoquinones in seeds and seedlings of Euclea natalensis’’. South African Journal of Botany 2007; 73(4): 606-610. 14. Sobhy EA, Feky SS. ‘‘Chemical constituents and antimicrobial activity of Helichrysum stoechas’’. Asian journal of plant sciences 2007; 6(4): 692-695. 15. Koyama J. ‘‘Anti-Infective Quinone Derivatives of Recent Patents’’. Recent Patents on Anti- Infective Drug Discovery 2006; 1: 113-125. 16. Imelouane B, Amhamdi H, Wathelet JP, Ankit M, Khedid K, Bachiri A. ‘‘Chemical Composition and Antimicrobial Activity of Essential Oil of Thyme (Thymus vulgaris) from Eastern Morocco’’. International Journal of Agriculture and Biology 2009; 11(2):205-208. 17. Bamuamba K, Gammon DW, Meyers P, Dijoux- Franca MG. ‘‘Anti-mycobacterial activity of five plant species used as traditional medicines in the Western Cape Province (South Africa)’’. Journal of Ethnopharmacology 2008; 117(2-8):385-390. 18. Gandhi, N.R., Moll, A., Sturm, A.W. Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa. Lancet., 2006; 368(9547): 1575-1580. 19. Ma Z, Lienhardt C, McIlleron H, Nunn AJ, Wang X. Global tuberculosis drug development pipeline: the need and the reality. Lancet 2010; 375(9731): 2100-2109. 20. Diacon, A.H., Pym, A., Grobusch, M. The diarylquinoline TMC207 for multidrug-resistant tuberculosis. New Engl. J. Med., 2009; 360(23): 2397-2405. 21. Gler, M.T., Skripconoka. V., Garavito, E. Delamanid for multidrug-resistant pulmonary tuberculosis. N. Engl. J. Med., 2012; 366(23): 2151-2160.

Atibala [Abutilon indicum] is widely used as a drug in many diseases. However neither the dose nor the duration of treatment are authenticated. Considering vrumhana effect of atibala, we propose an experimental study employing albino rats for attaining the dosage and duration of treatment. Once dosage and duration of treatment is known it could be useful in the treatment of other ailments also. REFERANCES · 1 1) NARAYAN AIYER M.A. Abutilon indicum, Pharmacognosy of ayu. Drugs, Kerala, Tri, Uni. 1951, Vol. 5, 104 – :107 2) KIRTIKAR K.R. & BASU B.D. Abutilon indicum, Indian Medicinal Plants, 1987, vol 1, 314 – 316 3) CHOPRA R. N., NARAYAN S. L., CHOPRA 1. C. Abutilon indicum, Glossary of Indian Medicinal Plants, 1992,3rd ,vol. 1, 1-2 4) ASOLKAR L. V., KAKKAP K.K., CHAKRE O.J. Abutilon [Malvancene], Glossary of Indian Medicinal Plants with active principles, 1965 – 1981, part 1 5) SHARMA P. V. AHMAD Z. A., SHARMA V. V. Analgesic constituent of Abutilon indicum, Indian Drugs 1989, vol. 26 – 7, 333 6) VAIDYA BHAPALAL. Atibala, Nigantu Adarsha, 1968, first edition, Chau. Bharati Academy 7) MISHRA V. L. Atibala, Dravya guna hastamalaka, 1986 2nd edition, Chau. Bharati Academy 8) CHUNEKAR K. C. Atibala, Bhavaprakas Nigantu, 1998, 7th edition, Chau, Bharati Academy 9) SHARMA P. V. Atibala, Dravya guna vignana, 1998, 10th edition, Chau, Bharati Academy

There are certain things which are harmful for human being. Metallic Poisons are one of them. In many Ayurvedic prerarations Vanga is widely used.But it is used after sodhana & marana process.As the Tin-toxicity affects the human life, it is necessary to test these old concepts against the current development and available parameters. Also it is important to test it’s safety and must be ensured if it is to be used in human being or not. Acute Toxicity study of vanga is carried out by means of LD50 studies. LD50 study of three samples was carried out in IDRAL (Pune). Changes in toxicity of Vanga are observed in 3 stages. REFERANCES · 1 1.Rasaratnasamucchaya –Shri. Dharmanand Sharma,2-revised edition,1999.(5/156). 2 SharangdharSamhita-Dr. Bramhanand Tripathi, ChoukhambaAcademy, Revised edition 2001. 3. Ref. from Wikipedia commons. 4. Modis MedicalJurisprudenceand Toxicology.

Today’s life-style is the root cause of many diseases. We are crazy for fast food, cold drinks, travelling on bike .Due to this change in life-style , every class of society is prone to suffer from joint-pain . .In Ayurveda, there are many diseases in which Sandhishula, is cardinal symptom e.g. .Sandhiwata, Asthimajjagata vata, Amavata, Kroshtukshirsha, Vata-rakta. According to modern medicine also, the diagnosis may be Arthrities,-(OA or RA ) or Gout , joint pain is common symptom in all these diseases. Aims and Objects- The task of medicine is to preserve and restore health and to relieve suffering. Understanding pain is essential to both these goals. Because , pain is universally understood as a signal of disease. It is the most common symptom that pt .to a physician's attention. If we are able to treat “pain” we will certainly conquer one part of sadness. Efforts are made to overcome this joint –pain by all branches of medicine. For the same purpose, trial drug has been selected. It was our try to study this un explored herb. Oil is most balancing substance for vata. .Hence taila –kalpana was selected. Result- Ayurvedic abhyanga has many advantages ever any other oriental. it improves circulation in the body .Cleanse and open channels of circulation and elimination . It increases the secretion of hormons from skin. REFERANCES · 1 CharakSamhita with Ayurvedadipika commentary of Chakrapanidutta published by Choukhamba Academy 3rd edition.Chikitsasthan(28/33,37,196). Bhavprakash By Shri. Bramhmashankar Misra and Rupalalji Vaidya, 2. .Astangahridaya-Sarvangasunderand Arunadutta commentary,collectedby Dr. Annakunta 4thedition1995Sutrasthan(2/8). 3 . SharangdharSamhita-Dr. Bramhanand Tripathi, ChoukhambaAcademy, Revised edition 2001.Madhyam-khand(-9/2.,13) . 4. Susrutsamhita edited by Ambikadutta Shastri,1996,-chikitsashthan(24/30). 5. Ref. from Wikipedia commons.

Rasa refers to the total subjective experience arising on placing any substance in the mouth. Rasa concept described is a pharmacodynamic principle and serves as a tool to explain panchabhoutic constitution of the drug. A reputed formulation of Bhavaprakasha mentioned in hridroga adhikara is taken up to assess the rasa based on the lakshanas mentioned in classical ayurvedic texts. The formulation (2g) was administered to 30 participants and their responses after intake of the drug were recorded using a structured questionnaire. On analyzing the data it was found that the classical hridya yoga possesses katu rasa as the primary taste and tikta rasa as the secondary taste. REFERANCES · 1.1. Sharma RK, Bhagwan Dash editors, Charaka Samhita of Agnivesha, SootraSthana; Chowkhambha Sanskrit Series,Varanasi, Reprint 2014.,pp.448,459 2. Sharma RK, Bhagwan Dash editors, Charaka Samhita of Agnivesha, Sootra Sthana; Chowkhambha Sanskrit Series,Varanasi, (Reprint 2014.), pp.,458 3. Andrea M Dietrich Gary A Burlingame and Robert c Hoehn,Strategies for taste and odor tasting methods.Opflow Oct 2003 p-10-14 4. Yadavji Thrikamji Acharya Editor,Charakasamhitha, ChikitsaSthana26/45, Chowkambha Surabharathi Prakashan,2013 5. Bhavamisra, Bhavaprakasa Vol. 2,(Madhyma & Uttara Khanda) 34/12,Translated by Prof.K.R.Srikantha Murthy;Chowkambha Krishnadas Academy,Varanasi, 4th Ed , 2009, pp: 450 6. Dr Shivprasad Sharma editor,Vaghbata, Ashtangasamgraha,2009 Chowkhambha Sanskrit Series,Varanasi pp 153. 7. Dr G.S Pandey Editor,(2010) Bhavaprakasanighantu, Chowkambha bharathi Academy,Varanasi,pp 7,42,44,15,13,236,91 8. Subramani Parasuraman, Gan Siaw Thing, and Sokkalingam Arumugam Dhanaraj, Polyherbal formulation: Concept of ayurveda, Pharmacogn Rev. 2014 Jul-Dec; 8(16): 73–80.

Ayurveda is a sacred science of life. In all the living beings the matter and energy is existing in the form of Dosha, Dhatu & Mala. As we know that the reading is the source of obtaining the information only. The knowledge of the subject demands precise manner of study which called Analysis. Since, ancient time grammar has been tool for understanding and writing various texts whether literal work or any scientific. As Sastras were written in Sutra Roopa, Vyakarana (grammar) has always turned to be helping hand in extracting true meaning. ‘Tarunasthi Namayante….”, which states the relation of type of Asthi (bone) and type of Bhagna (fracture) generally occurring in them; citied from Nidana Sthana, giving sufficient proof of clinical orientation of Acharya. Classical grammatical analysis includes study of Dhatupada, their meaning, correlation with meanings in contemporary literature and their validation. After validation of we can say that principles both clinically and literally about classification of Asthi can be verified. As each principle is accountable so, it is upon us to elaborate and understand it under present circumstances. We can say that knowledge of classical grammar is of extreme importance to bring out real meaning out of Sutras of classical text, thus making our principles more acceptable to new era and to take their maximum utilization in serving the nation. REFERANCES · 1. Jadavji T, editor. Commentary Nibandhasamgraha of Dalhana, on Sushruta Samhita of Sushruta, Sutra Sthana; ch 15 Doshadhatumalakhayavriddhivigyaniya, verse 3, Varanasi: Chaukhamba Surbharti Prakashan; 2012. p. 67 2. Jadavji T, editor. Commentary Nibandhasamgraha of Dalhana, on Sushruta Samhita of Sushruta, Nidana Sthana; ch 15 Bhagnanam Nidanam, verse 16, Varanasi: Chaukhamba Surbharti Prakashan; 2012. p. 330 3. Jadavji T, editor. Commentary Nibandhasamgraha of Dalhana, on Sushruta Samhita of Sushruta, Sharir Sthana; ch 5 Sharirsankhyavyayakranam Shariram, verse 22, Varanasi: Chaukhamba Surbharti Prakashan; 2012. p. 366 4. Jadavji T, editor. Commentary Nibandhasamgraha of Dalhana, on Sushruta Samhita of Sushruta, Sharir Sthana; ch 5 Sharirsankhyavyayakranam Shariram, verse 23, Varanasi: Chaukhamba Surbharti Prakashan; 2012. p. 366 5. Jadavji T, editor. Commentary Nibandhasamgraha of Dalhana, on Sushruta Samhita of Sushruta, Sutra Sthana; ch 15 Doshadhatumalakhayavriddhivigyaniya, verse 4-1, Varanasi: Chaukhamba Surbharti Prakashan; 2012. p. 67 6. Jadavji T, editor. Commentary Ayurvedipika of Chakrapanidatta, on Caraka Samhita of Caraka , Sharir Sthana; Ch. 7 SharirsankhyaShariram, verse 6. Varanasi: Chaukhamba Surbharti Prakashan; reprint 2011. p. 337 7. Vaidya Yadunandana Upadhyaya, editor. Hindi commentary Vidyotini by Kaviraja Atrideva Gupta, on Ashtanga Hrudaya of Vagbhata, Sharir Sthana; Ch.3 Athatoangvibhaga Shariram, verse 15. Varanasi; Choukhambha Prakashan, reprinted in 2010 , Pp 251 8. Ayurvedalankar Srisatyapala Bhisagacharya, editor. With Hindi Commentary Vidyotini on Kasyapa Samhita of Vrddha Jivaka:, revised by Vatsya, Sharir sthana; ch.1 Sharirvichaya Shariradhyaya , verse 1. Varanasi: Chaukhambha Sanskrit Sansthan; Reprint 2010. p.75 9. Jadavji T, editor. Commentary Nibandhasamgraha of Dalhana, on Sushruta Samhita of Sushruta, Sharir Sthana; ch 5 Sharirsankhyavyayakranam Shariram, verse 18, Varanasi: Chaukhamba Surbharti Prakashan; 2012. p. 365 10. Jadavji T, editor. Commentary Nibandhasamgraha of Dalhana, on Sushruta Samhita of Sushruta, Sharir Sthana; ch 5 Sharirsankhyavyayakranam Shariram, verse 20, Varanasi: Chaukhamba Surbharti Prakashan; 2012. p. 366 11. Jadavji T, editor. Commentary Nibandhasamgraha of Dalhana, on Sushruta Samhita of Sushruta, Sharir Sthana; ch 5 Sharirsankhyavyayakranam Shariram, verse 20, Varanasi: Chaukhamba Surbharti Prakashan; 2012. p. 366 12. Jadavji T, editor. Commentary of Bhoja, on Sushruta Samhita of Sushruta, Sharir Sthana; ch 5 Sharirsankhyavyayakranam Shariram, verse 20, Varanasi: Chaukhamba Surbharti Prakashan; 2012. p. 366 13. Jadavji T, editor. Commentary Nibandhasamgraha of Dalhana, on Sushruta Samhita of Sushruta, Nidana Sthana; ch 15 Bhagnanam Nidanam, verse 16, Varanasi: Chaukhamba Surbharti Prakashan; 2012. p. 330 14. Kanaklal Sarma, editor. With Dhatvartha Prakasika notes on The Dhatupatha of Panani, edition 2nd , Varanasi: Chaukhamba Sanskrit Series Office; 1969 15. Sir Monier Monier- Williams editor, A Sanskrit- English Dictionary, New Delhi ,1st edition Motilal Banarsidass Publishers; 2011 16. Raja Radha Kanta Deva editor; Shabdkalpadrum; Vol (1-5); edition 3rd; Varanasi: Chowkhamba Sanskrit Series Office: 1967. P 17. Sir Monier Monier- Williams editor, A Sanskrit- English Dictionary, New Delhi ,1st edition; Motilal Banarsidass Publishers; 2011 18. J. Maheshwari; Essential Orthopaedics; edition 3 revised; 7th reprint ; Ch 1 Orthopaedic Trauma; Introduction: New Delhi Jaypee Brothers Medical Publishers; 2011, p. 1-7 19. Donald Venes, editor; Taber’s Cyclopedic Medical Dictionary; Philadelphia, edition 21st ; F. A. Davis Company; 2005

Romashatan lepa” is the drug selected for the study on the significance & symptom of hypertric oasis. Study drug contains shudha Hartal (Yellow arsenic), shudha Manahsheela (Red arsenic0, Shankha bhasma (incinerated conch shell) & Sudha (chalk-calcium carbonate) with media of lime juice. For hair removal two main therapies are in practice 1) Depilation & 2) Epilation. Depilation includes Shaving, use of chemicals for hair removal. Epilation therapy is of two types permanent & temporary, this mainly include electrolysis, laser hair removal etc. Drug therapy was given to patients of hypertricosis for 10min. On each visit having follow up of 30days interval. The result shows that satisfactory hair removal property of test drug and its effect on hair growth. REFERANCES · Caraka Samhita : Yadavaji Trikamji Acarya : IV, Edition, Nimaya Sagar Press, Bombay. · Bhaishajyaratnavali- · Rasaratnasamucchaya- · API Text Book of medicine-

Presently it is being globally accepted that medicinal plants play a major role in providing health benefits to human beings. Maximum Ayurvedic medicines are plant based drugs. The complex composition of medicinal plant based drugs has a major challenge for quality control. Phytochemical study is the most important part for standardization of the medicinal plant base drugs. One important Ayurvedic drug i.e. Alambushadi Churna tablet had been selected from Ayurvedic famous book named Bhava Prakasha for the Phytochemical study. It is mainly used in the treatment of disease Amavata (Rheumatoid arthritis). The Phytochemical study revealed that reducing sugars, tannin, phenolic compounds, flavonoids, saponin glycosides and gum were present into the sample of Alambushadi Churna tablet. REFERANCES 1 Madhavakara, Rakshita V, Dutta S, Shastri S, Upadhyaya Y. Madhava Nidana (Madhukokosha Vyakya with Vidyotini Hindi Commentary), Ed 26, Part. I, Chaukhambha Sanskrit Sanathana, Varanasi, 1996, 460-464. 2 Harrison TR, Anthony S. Fauci et al. Harrison’s Principles of Internal Medicine, Ed 14, Vol. 2, McGraw Hill, New York, 1998, 1885. 3 Bhavamishra, Mishra B S, Bhavaprakasha with Vidyotini Hindi Commentary, Ed 9, Part. II, Chaukhambha Sanskrit Sansthana, Varanasi, 2005, 287. 4 Harborne JB, Phytochemical methods, Ed 2, Chapman and Hall, Landon, 1984. 5 Sharma PV, Dravyaguna Vijnana, Ed 8, Vol. II, Chaukhambha Bharati Academy, Varanasi, 1986. 6 Chopra RN, Indigenous Drugs of India, Ed 2, U N Dhur and Sons Pvt. Ltd., Calcutta, 1959.

Psorasis is not considered as fully skin disease and have negative impact on many systems of the body as well as mind and social well being .This disease has affected 3% of the world. Many research and clinical trials are going on as well as completed but still it’s a topic of study. According modern science this has been associated with increased risk of cancers, CVD, ulcerative colitis and many more. According to ayurveda it considered as kustha and mainly involves dushti of rakta,lasika ,twak,mansa and three doshas. Aama is one of the important focusing factor for every dushti in Annavaha srotas as well as it is the root cause of all diseases explained by ayurveda.The concept of Ama differs and having its own outstanding pattern and causative factors for every diseases as a root cause. Study of factors involved and exact pattern of Annavaha srotas dushti in etiopathogenesis of psoriasis ,may help to prevent the further spread and to control of this disease. REFERANCES · 1. Charak chikikitsasthan- 7/4-8, sootrasthan-26, Madhav nidan kushtha 25-49 Parisi R, Symmons DP, Griffiths CE, Ashcroft DM; Identification and Management of Psoriasis and Associated ComorbidiTy (IMPACT) project team (February 2013). "Global epidemiology of psoriasis: a systematic review of incidence and prevalence". J Invest Dermatol 133 (2): 377–85. doi:10.1038/jid.2012.339. PMID 23014338. ^ Chong HT, Kopecki Z, Cowin AJ (August 2013). "Lifting the silver flakes: the pathogenesis and management of chronic plaque psoriasis". Biomed Res Int 2013 (168321). doi:10.1155/2013/168321. PMC 3766987. PMID 24062996