Volume 8, Issue 6

Diabetes mellitus and its complication are going to a burden for human kind .Diabetes mellitus is a metabolic disorder where primary defect lies in glucose metabolism. As a result there is wide spread multi-organ damage that ultimately encompasses virtually every system of body and consequently every specialty of medicine. The complication of diabetes mellitus is categorized into acute and chronic. Chronic complication of diabetes mellitus includes predominantly nephropathy, retinopathy and neuropathy. Peripheral neuropathy is the most common form of diabetic neuropathy. In ancient classical text of Ayurveda, diabetic peripheral neuropathy (DPN) has not been described separately, rather than the most of neurological symptoms of diabetic neuropathy has may be considered as symptoms of various pathophysiological phenomena that occurs in madhumeha, i.e. ojo visramsa , dhatukshaya and avarana. Key word - Diabetic peripheral neuropathy, Madhumeha, Ojo visramsa , Dhatukshaya, Avarana. 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Acharya,Vaidya Jadavji Trikamji and Kavyatritha,Narayan Ram Acharya:Susruta Samhita with Commentaries Nibandha samgraha of Dalhana and Nayacandrika Panjika of Gayadas on Nidana sthana; Chaukhamba Orientaliya,Varanasi,7th Edition,2010,Sharir sthan-4/12,13,P-356. 30. Acharya,Vaidya Jadavji Trikamji:Carak Samhita by Agnivesa,Revised by Caraka and Dridhavala with The Ayurveda,Dipika Commentary of Chakrapanidatta,Chaukhamba Prakashana,Varanasi,7th Edition:Reprint 2013,Chikitsa sthan-15/17,P-514. 31. Acharya,Vaidya Jadavji Trikamji and Kavyatritha,Narayan Ram Acharya:Susruta Samhita with Commentaries Nibandha samgraha of Dalhana and Nayacandrika Panjika of Gayadas on Nidana sthana;Chaukhamba Orientaliya,Varanasi,7th Edition,2010,Sharirsthan-4/29,P-357. 32. Acharya, Vaidya Jadavji Trikamji:Carak Samhita by Agnivesa,Revised by Caraka and Dridhavala with The Ayurveda,Dipika Commentary of Chakrapanidatta,Chaukhamba Prakashana,Varanasi,7th Edition:Reprint 2013,Chikitsa sthan-28/20,21,P-617. 33 Upadhyay Prof.Yadunandana:Madhav Nidana of Sri Madhavkar with Madhukosa by SriVijayaraksita and Srikanthadatta with Vidyotini Hindi Commentary by Srisudarsana Shastri,Part-I,Chaukhamba Sanskrit Bhawan ,Varanasi,Edition:Reprint 2003,1st Chapter,Page-31

In Ayurveda the whole concept of fetal growth is included under the heading of Garbha. Here the essential factors of conception, time of conception followed by formation and its subsequent development to form an individual is stressed. The term ‘Garbha’ include zygote, embryo or fetus. Ayurvedic classics have lucidly elaborated the concept of garbha as well as the influencing factors for its growth and development starting from sukra-sonita samyoga. Fetal development includes continuous process of maturation of structure discussed under three period of gestation i.e. Germinal, Embryonic and Fetal period. The classics enriched with formation and subsequent development are highlighted under the term ‘vriddhi’. Different factors are considered for fetal growth like excellence of the factors responsible for production of fetus viz. Sadabhava (six factors for embryogenesis), Adoption of proper diet & regimen by the mother during pregnancy, Availability of nourishment through upasneha & upasveda, Kala (proper time) & Swabhava samsiddhi (instinctive or natural tendencies). Sadabhava in other way exhibit genetic influences by Matrija & Pitrija bhavas while Satmya & Rasaja bhavas come from maternal diet & regimen. Satva & Atma are the individual factors that come to garbha (fetus) itself. This concept of sadabhava highlights the development of a complete human being. Here Mahabhuta plays an important role in embryogenesis with the help of functions such as separation or segregation of cell mass, influences of different hormones, nourishment passing through chorionic villi in early part and later through umbilical cord, followed by stabilization and structural development of body parts, as well as symmetrical and chronological increase of all these structures are attribute to the functions of Vayu, Teja, Apa, Prithvi and Akash respectively. In applied aspects Garbhasosha, Nagodara, Upasushka etc are mentioned. Upasuska emphasised with intrauterine growth retardation (IUGR) while jataharini include intra-uterine growth retardation (IUGR) and intra-uterine death (IUD). The present work highlights all these concept of fetal growth interpreting with different aspects of embryology while morbidity stressed through teratology.

Ayurveda accepts all dravyas (substances) are panchabhautika (five elements) and dravya (substances) has the medicinal properties. Ama (biotoxin) and vitiated Vata (bioforce) are the main causative factor in the disease manifestation of Amavata (Rheumatoid arthritis). One important plant based Ayurvedic drug i.e. Alambushadi Churna have been selected from famous Ayurvedic book (i.e. Bhava Prakasha) in context of Amavata for its probable standardization. It is a poly herbal Ayurvedic drug. The Rasa, Guna, Virya, Vipak and Karma of ingredients of Alambushadi Churna help to reduce the clinical manifestations of Amavata (Rheumatoid arthritis). The Physico-chemical study revealed that the Alambushadi Churna tablet contained more moisture, less inorganic constituents and more water soluble constituents. The Phytochemical study revealed that reducing sugars, tannin, phenolic compounds, flavonoids, saponin, glycosides and gum were present into the sample of Alambushadi Churna tablet. Four phytocostitutents were indicated under short ultra violet ray (254 nm) and five phytocostitutents were indicated under long ultra violet ray (366 nm) by thin layer chromatography study on the sample of Alambushadi Churna tablet.

To exploit and utilize the resources of cordyceps cicadae and lay a theoretical foundation for related products, this paper briefly reviews the research progress of cordyceps cicadae's pharmacological effects in recent years, indicating that cordyceps cicadae has many pharmacological activities, such as protecting kidney, anti-convulsion, anti-oxidation, anti-tumor, antibiosis, analgesic and so on, and can be used as one of the main substitutes of Cordyceps sinensis.