Volume 15, Issue 2

Migraine is an episodic headache disorder usually characterized by pain involving either half of the head. According to International headache society, Migraine constitutes 16% of the primary headache and affects about 10-20% of the general population. Kshayaj Shira roga is mentioned under Shiroroga (Diseases of head) which can be correlated with migraine. Nasya Karma (Errhine Therapy) is considered as the best therapeutic intervention in Shiro Roga by Acharya Charaka. Panchendriya vardhan taila has shown vata hara properties along with nutrition effect on sense organs. So, an attempt has been made to assess the efficiency of this oil in an acute as well as chronic condition of migraine. Marsha nasya of panchendriya vardhan taila on a patient with acute migraine was given which was followed by a regular pratimarsha nasya of the same for one month to deal with the chronic aspect. The medicine showed instant effect on application during acute condition in this patient.This case study had an acute excruciating one sided pain during the visit but had milder forms of pain for the last 6 months. The patient neglected the pain for this whole period and resorted to local painkillers. This was a case of kshayaj shiro roga due to the etiology of several hours of screentime, extreme physical exertion and irreregular sleeping patterns. To tackle the current pain a nasya of pachendriyavardhan taila was given with a higher dose. This showed immediate relief in the pain, photophobia and phonophobia.So we decided to tackle the chronic recurrence of the disease with a pratimarsha nasya of the same.

The World Health Organization (WHO) estimates that oral disorders impact around 3.5 billion people worldwide and are a major concern. Tooth decay, periodontitis, dentition loss, oral and lip malignancies, and dry mouth are the most prevalent oral health issues [1]. Caries and severe periodontal infections are significant causes of tooth loss in adults, even with the natural aging process [2] . The frequency of periodontitis rises to 70–85% in people aged 60–65.[3] One of the most important issues pertaining to tooth health is periodontal disease. Only a small percentage of individuals worldwide are thought to have completely healthy teeth, and the WHO estimates that up to 3.5 billion people may be afflicted by oral disorders. REFERENCES: 1. Peres, M.A.; Macpherson, L.M.D.; Weyant, R.J.; Daly, B.; Venturelli, R.; Mathur, M.R.; Listl, S.; Celeste, R.K.; Guarnizo-Herreño, C.C.; Kearns, C.; et al. Oral diseases: A global public health challenge. Lancet 2019, 394, 249–260. 2. WHO. Europe Disease Prevention—Data and Statistics. 2018. 3. Patel, R. The State of Oral Health in Europe-Report Commissioned by the Platform for Better Oral Health in Europe. 2012. 4. Botelho MA, Bezerra Filho JG, Correa LL, FonsecaSG, Montenegro D, Gapski R, et al. Effect of a novel essential oil mouthrinse without alcohol on gingivitis: A double blinded randomized controlled trial. J Appl Oral Sci 2007;15:175 80. 5. World Health Organization. Traditional Medicine. Geneva; 2008. Available from: http://www.who.int/medicines/areas/traditional/en/. 6. N.Jagan Rao,K.R.Subash,K.Sandeep Kumar,Role of Phytotherapy in gingivitis-A review,International Journal of Pharmacology.,8(1),1-5,2012. 7. More G, Tshikalange TE, Lall N, Botha F, Meyer JJ. Antimicrobial activity of medicinal plants against oral microorganisms. J Ethnopharmacol 2008;119:473-7. 8. Prakash Pai G, M. M. Dayakar, Anjali R. Nath, G. Ashwini., Phytotherapeutics in the management of periodontal disease - A review, SRM J Res Dent Sci 2019;10:82-9. 9. DrSumedh lone, Dr. Amit Saragade, Dr. Avadhesh Tiwari, Dr. Monica Maha Jani, Dr. Kuldeep Patel, Dr. Manisha Rathod, Dr. DevendraWarghane& Dr. SiddharthNarote. Ayurvedic dentistry: A Doctor in concept, International Journal of Current Research vol.10, Issue, 12, pp.76025-76027, dec2018. 10. Deepthi. S, Andhad, Supreetha, Shylaja. M. D, Shilpa M & Vinay Kumar K Ayurvedic Medicine and Oral HealthInternational Journal of Oral care and Research oct-dec 2015: volume 3 issue 4. 7. 11. M. Raj Mohan, P. D Madan Kumar, M. Shiva Kumar K & S Uma, Awareness on Oral Health among Ayurvedha and Sidha practitioner's, Medical Journal of Islamic World Academy of Sciences20:2,pp. 43-48, 2012. 12. Shetty Y.S\., Shankarapillai R., Vivekanandan G., Shetty R.M., Reddy C.S., Reddy H. and Mangalekar S.B. Evaluation of the Efficacy of Guava Extract as an Antimicrobial Agent on Periodontal Pathogens. J Contemp Dent Pract 2018 ;19(6):690-697. 13. Rai D, Singh JK, Roy N, Panda D. Curcumin inhibits FtsZ assembly: An attractive mechanism for its antibacterial activity. Biochem J 2008;410:147 55. 14. Tyagi P, Singh M, Kumari H, Kumari A, Mukhopadhyay K. Bactericidal activity of curcumin I is associated with damaging of bacterial membrane. PLoS One 2015;10:e0121313. 15. Hu P, Huang P, Chen MW. Curcumin reduces Streptococcus mutans biofilm formation by inhibiting sortase A activity. Arch Oral Biol 2013;58:1343 8. 16. Song J, Choi B, Jin EJ, Yoon Y, Choi KH. Curcumin suppresses Streptococcus mutans adherence to human tooth surfaces and extracellular matrix proteins. Eur J Clin Microbiol Infect Dis 2012;31:1347 52. 17. Rudrappa T, Bais HP. Curcumin, a known phenolic from Curcuma longa, attenuates the virulence of Pseudomonas aeruginosa PAO1 in whole plant and animal pathogenicity models. J Agric Food Chem 2008;56:1955 62 18. Sharma H.M., Deepika P.C., Venkatesh M.P., Chandan S and Shashikumar P. Efficacy of 3% Psidium guajava local drug delivery in the treatment of chronic periodontitis : A randomized controlled trial. Int.J. Oral Health Dent. 2021 Jan 1;13(1):17–23. 19. Geoghegan F, Wong RW, Rabie AB. Inhibitory effect of quercetin on periodontal pathogens in vitro. Phytother Res 2010;24:817 20. 20. Chattopadhyay RR. Possible mechanism of antihyperglycemic effect of Azadirachta indica leaf extract: Part V. J Ethnopharmacol 1999;67:373 6. 21. Parida MM, Upadhyay C, Pandya G, Jana AM. Inhibitory potential of neem (Azadirachta indica Juss) leaves on Dengue virus type 2 replication. J Ethnopharmacol 2002;79:273 8. 22. Patel VK, Venkatakrishna Bhatt H. Folklore therapeutic indigenous plants in periodontal disorders in India (review, experimental and clinical approach). Int J Clin Pharmacol Ther Toxicol 1988;26:176 84. 23. Geeta Vasudevan DM, Kedlaya R, Deepa S, Ballal M. Activity of Ocimum sanctum (the traditional Indian medicinal plant) against the enteric pathogens. Ind J Med Sci 2001; 55(8):434-438. 24. Prakash P, Gupta N. Therapeutic uses of Ocimum sanctum Linn (Tulsi) with a note on eugenol and its pharmacological actions: A short review. Indian J Physiol Pharmacol 2005;49:125 31 25. Stowe CB. The effects of pomegranate juice consumption on blood pressure and cardiovascular health. Complement Ther Clin Pract 2011;17:113 5. 26. Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med 1999;341:738 46. 27. Ramesh A., Varghese S.S., Doraiswamy J.N and Malaiappan S. Herbs as an antioxidant arsenal for periodontal diseases. J. Intercult. Ethnopharmacol. 2016 Jan;5(1):92. 28. De Almeida, J.M.; Marques, B.M.; Novaes, V.C.N.; de Oliveira, F.L.P.; Matheus, H.R.; Fiorin, L.G.; Ervolino, E. Influence of adjuvant therapy with green tea extract in the treatment of experimental periodontitis. Arch. Oral Biol. 2019, 102, 65–73. 29. Chava, V.K.; Vedula, B.D. Thermo-Reversible Green Tea Catechin Gel for Local Application in Chronic Periodontitis: A 4-Week Clinical Trial. J. Periodontol. 2013, 84, 1290–1296. 30. Hyun Koo, Pedro L. Rosalen, Jaime A. Cury et.al. Effects of Compounds found in Propolis on Streptococcus mutans Growth and on Glucosyl-transferase Activity. Antimicrob. Agents Chemother 2002;46: 1302-1309. 31. Martin MP, Pileggi R . A quantitative analysis of Propolis: a promising new storage media following avulsion. Dent Traumatol 2004;20: 85-89. 32. Khorana ML, Rajarama Rao MR, Siddique HH. Studies on the pharmacology of Terminalia chebula Retz. J Sci. Ind. Res. 1960;19: 60. 33. Wang MY, West BJ, Jensen CJ, Nowicki D, Paul AK, et al. (2002) Morinda citrifolia (Noni): a literature review and recent advances in Noni research. Acta pharmacol Sin 23 (12): 1127-1141. 34. Duke JA, Bogenschutz M (2002) Hand book of medicinal plants. 2nd (Edn.), CRC Press, Boca Raton, Florida, pp: 529. 35. Mc Clatchey W (2002) From the Polynesian healers to health food stores; changing perspectives of Morinda citrifolia (Rubiaceae). Integr Cancer Ther 1(2): 110-120. 36. 5. Wang MY, West BJ, Jensen CJ, Nowicki D, Su C, et al. (2002) Morinda citrifolia (Noni): a literature review and recent advances in Noni research. Acta Pharmacol Sin 23(12): 1127-1141. 37. Potterat O, Hamburger M (2007) Morinda citrifolia (Noni) fruit--phytochemistry, pharmacology, safety. Planta Med 73(3): 91-199. 38. Glang J, Falk W, Westendorf J (2013) Effect of Morinda citrifolia L. fruit juice on gingivitis/periodontitis. Mod Res Inflamm 2(2): 21-27. 39. Aldi Y, Khairiyah H, Kasuma N, Banowo AS, Afriwardi (2019) The Effect of Noni Fruit Extract (Morinda citrifolia L.) in Gingivitis Patient. Pharmacognosy Journal 11(4): 678-682. 40. Gu H, Boonanantanasarn K, Kang M, Kim I, Woo KM, et al. (2018) Morinda citrifolia leaf extract enhances osteogenic differentiation through activation of wnt/βcatenin signaling. J Med Food 21(1): 57-69. 41. Anarthe R, Mani A, Kale P, Maniyar S, Anuraga S (2017) Herbal approaches in periodontics. Gal Int J Heal Sci Res 2(1): 18-25. 42. Boonanantanasarn K, Janebodin K, Suppakpatana P, Arayapisit T, Chunhabundit P, et al. (2012) Morinda citrifolia leaf enhances in vitro osteogenic differentiation and matrix mineralization by human periodontal ligament cells. Dentistry 2(4): 130. 43. Samjotha Dharma and Nagarathna D V. (2021); Nanotechnology- Advancements in Periodontal Disease Treatment: A Review. IAR J Med Sci, 2(1); 24-28. 44. Mohsen Yazdanian , Pouya Rostamzadeh,Mahdi Rahbar , Mostafa Alam , Kamyar Abbasi , Elahe Tahmasebi ,Hamid Tebyaniyan , Reza Ranjbar , Alexander Seifalian , and Alireza Yazdanian, The Potential Application of Green-Synthesized Metal Nanoparticles in Dentistry: A Comprehensive Review, Bioinorganic Chemistry and Applications Volume 2022

Ayurveda on the global front may act as a whistle-blower in healthcare reforms by seizing opportunities, exploring the enshrined principles depicted in Ayurveda, and uncovering its secrets and practical applications with a scientific orientation. Principles and Policies just on paper are actual obstacles. It's high time to shatter the silence, and implementation on the ground level is the first and foremost requirement for upliftment. Therefore, it's time to opt for a forward-thinking strategy. Diseases are the tax on pleasures. JOHN RAY As in the present era, we all know technology drives changes in health care. Science of communication like deploying telemedicine consultants, surveillance, virtual expansion introduction of artificial intelligence [AI], and 3-dimensional technological innovations is basking in appreciation for their assistance in the healthcare sector in presenting precise pictures and status of the disease. Sometimes, needlework works efficiently as compared to a sword, so the case studies do not have Less importance as they are being executed with diversified geographical, social, and environmental conditions, and also patients with diverse mental, physical, and economic statuses enhance the spectrum of research work. In this article, from the clinician's point of view, the proposed designed model may add vibrancy to stagnant research, case studies, and scientific documentation. strategically a framework for the district-wise model can be executed assuming that if there are 40 Ayurveda dispensaries or 15-25 bed hospitals in a particular district every medical officer assigned a task for at least ten new cases in a month with proper documentation, Investigation, ultrasonography reports from the commencement, follow-ups, post-treatment outcomes. Ten cases per medical officer in a month means four hundred cases can be accumulated as a record or documents, in turn around forty-eight hundred documents in a year. The outcomes from these case studies on the ground level can provide actual data to premium research institutes to discriminate impact over health between rural or urban area populations. As we all know sudden emergence of infectious diseases like COVID-19 or pandemics requires big and diverse sample sizes or bulk data for assessment and conclusion, so such implementations need of the hour. Let us not squander opportunities to explore, reinvent, and re-establish Ayurveda on the same designation as envisioned by our ancient intellects just amplify stories of resilience, and channel its potential into fostering hope for the future establishment of our pathy as it assists in flattening the curve of emerging disorders in the healthcare sector and reshaping the health landscape of the country.

We humans had to deal with wounds since we existed. From a simple cut to large bleeding wounds, there are many varieties. Wounds are described by the time and level of understanding of humans. This article is a small attempt to study wounds from different literature and to evaluate their current situation.

Ashwagandha (Withania somnifera), a widely used Ayurvedic herb has garnered significant attention for its potential benefits in improving male reproductive health. This review comprehensively examines the scientific evidence supporting the use of Ashwagandha in addressing male infertility. Several studies have stated that use of Ashwagandha can lead to improvement in sperm count, its mobility and morphology. Studies have demonstrated Ashwagandha's ability to modulate the levels of reproductive hormones, including testosterone, LH and FSH which are essential for spermatogenesis. Ashwagandha may be a valuable adjunct for men with Infertility, particularly those with underlying oxidative stress or hormonal imbalance. Oral intake of Ashwagandha roots has been found to inhibit lipid peroxidation, improve sperm count and motility, and regulate reproductive hormone levels. The molecular mechanisms of these effects, however, are yet to be unveiled.

Amavata is a multifactorial disorder primarily rooted in the formation of Ama (toxins) due to impaired digestive fire (Agnimandya). The interaction of Ama with vitiated vata and kapha doshas leads to a pathological process known as dosha-dushya samurchana, resulting in the clinical manifestation of Amavata. The primary therapeutic objective in managing Amavata is to metabolize ama through pachana (digestive therapy) and to restore the balance of the disturbed vata and kapha doshas, thereby normalizing Agni and Doshic equilibrium. Treatment modalities encompass both Shodhana (purificatory procedures) and Shamana (palliative care) therapies. In Amavata, the accumulation of Ama and deranged vata dosha predominantly affects the joints, bearing a close resemblance to Rheumatoid Arthritis (RA) in modern medical science. RA is a chronic, non-suppurative, autoimmune inflammatory condition of the synovial joints, characterized by pain, swelling, stiffness, deformity, and potential systemic involvement. While Ayurveda prescribes both Shamana (conservative management) and Shodhana (bio-purification) treatments, the modern approach includes anti-inflammatory agents, analgesics, corticosteroids, DMARDs, and biologics—many of which are associated with adverse effects. Ayurveda offers a holistic and sustainable approach to RA through principles like sadvritta (ethical and seasonal regimen), appropriate dietary planning, lifestyle modification, detoxification (Samshodhana Karma), and rejuvenation therapies. Emphasizing prevention over symptomatic relief, Ayurveda seeks to address the root cause of disease rather than merely its manifestations. This review aims to bridge traditional Ayurvedic knowledge and contemporary biomedical understanding by analyzing both classical Ayurvedic literature and modern scientific evidence. It underscores the promising role of integrative therapeutics in improving long-term patient outcomes and highlights the necessity for evidence-based validation of Ayurvedic treatment protocols in managing chronic autoimmune conditions such as Rheumatoid Arthritis.

This study investigates the biological activities of aqueous extract from the leaves of Carica papaya (C. papaya) and Psidiumguajava (P. guajava), focusing on their phytochemical composition and therapeutic potential, including antioxidant, anti-diabetic, anti-arthritic, anti-microbial, and wound healing properties. Phytochemical analysis revealed the presence of bioactive compounds such as alkaloids and phenols. Anti-oxidant screening demonstrated significant free radical scavenging activity for both the extracts. Both C. papaya andP. guajava exhibited promising anti-diabetic activity through notable inhibition of the enzyme alpha-amylase. Furthermore, the anti-arthritic potential of the extracts was evident from their ability to inhibit protein denaturation. However, anti-microbial activity against Escherichia coli, Staphylococcus aureus, and Candida albicans revealed no zone of inhibition. In wound healing assays, C. papaya extract significantly enhanced cell migration in L929 fibroblast cells, whereas P. guajava extract exhibited a slower rate of cell migration. These findings underscore the therapeutic potential ofC. papaya and P. guajava leaf extracts as natural remedies with multifaceted biological activities, warranting further investigation for clinical applications.

Mutrakrichhra, a urinary disorder known by dysuria, frequent urination, and burning sensation, is a prevalent health issue. Traditional Ayurvedic medicine has long recognized the therapeutic potential of Gokshura (Tribulus terrestris) for managing this condition. This review aims to evaluate the scientific evidence supporting the use of Gokshura in the treatment of Mutrakrichhra. In this present study, we are making efforts to arrange chronologically ayurvedic literature Review of Gokshura(Tribulus terrestris Linn.) in reference to treat Mutrakrichra Roga (urinary tract infection). In This comprehensive study, we found that Gokshura (Tribulus terrestris Linn.) has been defined single or in various Pharmacological compound preparations in reference to Mutrakrichra Roga.

Neuropathic pain is a severe form of pain that is brought on by dysfunction in the brain and is connected with a number of degenerative alterations in the nervous system. Hyperalgesia and allodynia are two of the main symptoms of pain. Many neurological diseases seen in chronic alcoholics are linked to dietary deficiencies, especially vitamin deficits that are crucial for healthy brain function. The brain may suffer from severe functional impairment and tissue damage, mostly neuronal and vascular, as a result of specific vitamin and nutritional shortages that develop in chronic alcoholics. Moreover, nutritional inadequacies in chronic alcoholics contribute to oxidative stress, metabolic dysfunction, ion channel dysfunction, and neurotransmitter dysfunction. There are numerous molecular mechanisms that contribute to the development of alcoholinduced neuropathy symptoms. A threonine/serine kinase protein kinase C (PKC) regulates various body functions like cell growth and differentiation, release of neurotransmitters, excitation of cellular membranes and in memory. It is necessary to investigate all connected pathways in order to create an effective therapy for neuropath disease.

Ocuserts represent a significant advancement in ophthalmic drug delivery, offering a controlled and sustained release of medications directly to the eye. Unlike conventional eye drops and ointments, which suffer from rapid drainage and require frequent administration, ocuserts provide prolonged drug contact time, improving bioavailability and patient compliance. These thin, flexible inserts utilize advanced formulation techniques, including solvent casting, glass substrate methods, and melt extrusion, incorporating rate-controlling membranes and biodegradable polymers to regulate drug diffusion, osmosis, or bio-erosion. Factors influencing ocusert efficacy include polymer type, drug solubility, ocular physiology, and external environmental conditions. Rigorous evaluation parameters, such as thickness uniformity, drug content assessment, and in vitro release studies, ensure safety and therapeutic effectiveness. Clinical applications of ocuserts span various ophthalmic conditions, including glaucoma, dry eye syndrome, infections, and post-surgical inflammation. Their regulatory compliance and stability testing ensure long-term efficacy and patient safety. Future developments aim at enhancing ocusert technology through personalized medicine and environmentally sustainable solutions, making them a promising alternative in ocular therapeutics. REFERENCE 1. Vishal Kumar. Ocular drug delivery system: challenges and approaches. International Journal of Applied Pharmaceutics.2020 (Sep-Oct); Vol 12, Issue 5 2. Manthina V ,Varma,et al. Factors Affecting Mechanism and Kinetics of Drug Release from Matrix-Based Oral Controlled Drug Delivery Systems March 2004American Journal of Drug Delivery 2(1):43-57(15) 3. K. P. Sampath Kumar1, Debjit Bhowmik, et al.Ocular inserts: A Novel Controlled Drug Delivery System .The pharma innovation - journal Vol. 1 No. 12 2013:7-20 4. Kaishal Kumar. Review article on ocuserts a novel ophthalmic drug delivery system. Journal of Emerging Technologies and Innovative Research. August-2014 Volume 1 Issue 3; 1224 1227. 5. N. K. Sahane, N. K. Sahane. Controlled drug delivery fundamentals and application Ocular Inserts: A Review Drug Invention Today. January 2010 second edition page no 52. 6. Manish Kumar. Textbook of Novel drug delivery system; SIA publication. 7. Sahane, N., et al., Ocular Inserts-A Review. Drug Invention Today, 2010. 8. Menqi, S.A., Controlled and Novel drug delivery systems. CBS Publishers, 2004 9. Hajare, A., et al., A rational approach to ocular drug delivery systems: An overview. 2014. 10. Devhadrao, N. And M. Siddhaia, Review on ocular insert drug delivery system. Journalof Drug Delivery Therapeutics, 2018. 11. Preeti, K., et al., Ocusert as a novel drug delivery system. International Journal of Pharmaceutical and Biological Archives, 2013. 12. Navneet Nagpal, Sukhmanpreet Singh, et al. Ocuserts: A novel ocular-drug deliverymethod: An update. World Journal of Biology Pharmacy and Health Sciences. 2023 Jan 30;method: An update. World Journal of Biology Pharmacy and Health Sciences. 2023 13(1):470–7. 13. .Zaki, I., et al., A comparison of the effect of viscosity on the precorneal residence of solutions in rabbit and man. Journal of pharmacy and pharmacology, 1986. 38(6): p. 463-466. 14. Lee, V.H., Robinson, and J. R, Topical ocular drug delivery: recent developments and future challenges. Journal of ocular pharmacology and therapeutics, 1986. 2(1): p. 67-108. 15. Karthikeyan, D., et al., The concept of ocular inserts as drug delivery systems: An overview. Asian Journal of Pharmaceutics, 2014. 2(4): p. 192-200

Pharmaceutical formulations, like suspensions, play a crucial role in drug delivery. Due to their structural instability, various challenges arise during the development of these formulations. They typically consist of fine solid particles, ranging from 0.5 µm to 5.0 µm, which are suspended in a suitable vehicle, such as a liquid or semi-liquid, serving as the continuous phase. Suspensions have been utilized and marketed for many years; however, they face stability-related challenges that modern approaches and techniques, such as polymer-coated suspensions, nanosuspensions, and encapsulation, aim to overcome. Injectable suspensions are pharmaceutical preparations designed for injection into the body. Oral suspensions are pharmaceutical preparations containing finely divided insoluble particles dispersed in a liquid medium, intended for ingestion. They are a common dosage form, particularly for children, the elderly, and individuals with difficulty swallowing tablets or capsules.

Canna indica vernacularly known with numerous names such as Indian shot, Indian canna, African arrowroot, purple arrowroot, dev ked, bajarbattu etc. the plant thrives well in various tropical and sub-tropical atmosphere encompasses to family Cannaceae. The plant has been endowed with multitudinous chemical constituents. Canna indica demonstrates multifarious activity includes antioxidant, anti-inflammatory, hepatoprotective, antiviral, anti-diarrheal, anthelmintic, antibacterial, molluscicidal, cytotoxic, analgesic. hemostatic and immunomodulatory etc. The seeds of the plant are small, ovoid, globular, stiff and dense enough to sink in water. The seed of the plant would be used to treat variety of human condition. The ethanolic extract of seeds exhibited good antioxidant potential with IC50 of 18.80 compared to standard IC50 of 16.45. The antibacterial potential has been tested with gram positive S. aureus and gram-negative E. coli. The ethanolic extract herald a good antibacterial effect at 2% concentration as compared to 1%, the study also steered that the extract of seeds had greater antibacterial against gram negative E. coli.

In the Agada Tantra, Gara visha is associated with any substance, synthetic or artificial in origin, that harms the body directly or through its toxic metabolites. Acharya Susrutha mentions different types of poisoning in Garadhishthana. In modern times, people are consciously or unconsciously exposed to different types of poisons, natural or artificial in origin In this case, Mūṛvādi Agada of the Ashtanga Hridaya Uttarasthana Vishapratisheda chapter is recommended in the context of Garavisha. Mūṛvādi Agada is a unique and useful formula specially formulated for Agni Vikaras. REFERENCES: 1.1. Vagbhata. Ashtanga Hridaya (Sarvangasundara, Arunadatha, Hemadri, Ayurvedarasayana, comm, Sanskrit). Varanasi: Chaukamba; Reprint 2019. p. 902.35/57-58 2. Indian Pharmacopoeia. Government of India, Ministry of Health and Family Welfare. 2007;2:10201. 3. Evans WC. Trease and Evans Pharmacognosy. Singapore: Harcourt Brace and Company Asia Pvt. Ltd.; 1997. 4. Harborne.J.B, “Phytochemical Methods: A Guide to Modern Techniques of Plant Analysis.” 2nd Edition, Chapmann and Hall Publishers, London, 1998 5. Ram M, Abdin MZ, Khan MA, Jha P. HPTLC fingerprint analysis: a quality control for authentication of herbal phytochemicals. Inhigh-performance thin-layer chromatography (HPTLC) 2011 (pp. 105-116). Springer, Berlin, Heidelberg. 6. Sulaiman CT, Balachandran I. Chemical profiling of an Indian herbal formula using liquid chromatography coupled with electro spray ionization mass spectrometry. Spectroscopy Letters. 2015 Mar 16;48(3):222-6.

The diabetic foot ulcer is an infection caused in the feets or lower limbs of patients suffering from diabeties, it may be due to any injury or sometimes ulceration appears by itself. In this destruction of deep tissues are associated with neurological abnormalities and various degrees of peripheral vascular disease in the lower limb. Foot ulcers are a serious diabetic complication, and are a major cause of morbidity. It has been seen that about fifteen percent of Diabetics experience foot ulcers with major health-related decreases which hampers quality of life. A quarter of the Diabetic population is at increased risk of foot injuries as a result of the presence of Diabetic neuropathy or an arterial circulatory disorder. The healing duration for diabetic foot lesions takes months. It has been seen that fifteen percent of all foot ulcers in Diabetics do not heal before the patient's death. In modern medicine, its management is done by drainage of pus, debridement of dead tissues, use of appropriate dressings, medical and surgical treatment of infection and vascular reconstruction and or amputation or reconstructive foot surgery whenever necessary. However, the disease can be better treated in Ayurveda. This article aims to summarize the presentation, examination, work up, and Ayurvedic management of the patient with Diabetic foot. REFERENCES: 1. Gayle Reiber. The burden of diabetic foot ulcers, 1998;176(2) sup 1:5-10 2. Schaper NC. Diabetic foot ulcer classification system for research purposes: a progress report on criteria for including Reviews 2004;20 (Suppl 1):S90–5. 3. Boulton AJ, Armstrong DG, Albert SF, et al. Comprehensive foot examination and risk assessment. Diabetes Care. 2008;31:1679-1685. 4. Ibid, SushrutaSamhitaChikitsasthana2/86&88. 5. Ibid, SushrutaSamhitaChikitsasthana21/26. 6. Mason J, O’Keeffe C, Hutchinson A,McIntosh A, Young R, Booth A. A systematic review of foot ulcer in patients with Type 2 diabetes mellitus. II: treatment. Diabetic Medicine 1999;16(11):889–909. 7. Weerasekera KR, Dhammarathana I, Tissera AHM, et al. Anti- inflammatory activity of an ayurvedic herbomineral formulation: chandraprabha vati. International Journal of Recent Advances in Multidisciplinary Research.2015;2(6):0471-0475. 8. Sushruta, Sushruta Samhita with Nibandha sangraha commentary of Sri Dalhana Acharya and Nyayachandrika Panjika of Sri Gayadasa Acharya Vaidya Jadavji, Trikamji Acharya (Ed.), Vol. 822, Chaukambha Sanskrit Sansthan, Varanasi (2010). 9. Shekhar Reddy P. Aushadhi Yoga Gyanam. A Textbook of Rasashastra. Chaukhambha Orientalia. 2017. 10. Robbins JM, Strauss G, Aron D, Long J,Kuba J, Kaplan Y. Mortality rates and diabetic foot ulcers: is it time to communicate mortality risk to patients with diabetic foot ulceration? J Am Podiatr Med Assoc 2008. 11. Chakradutta:P.V.Sharma Sanskrit text with English translation published by: Chaukhambha orientalia delhi forth edition2007. 12. Govinda Dasa, Bhaishajya Ratnavali, Varanasi, Chaukambha Sanskrit Samsthana, Uttar Pradesh, 2002. 13. Singh N, Armstrong DG, Lipsky BA: Preventing foot ulcers in patients with diabetes. JAMA 293:217–228, 2005. 14. Sri Sadanand Sharma, Rasa Tarangini, Delhi, Motilal Banarasidas,1994. Sharangdhar Samhita, Bramhanand Tripathi, Chaukhamba Surbharti Prakashan, Varanasi, 2007, PP 488, Page number 153.

Bixa orellana L., commonly known as the annatto plant, is a tropical shrub native to the Americas and widely distributed in various parts of the world. This review aims to provide a comprehensive overview of the pharmacognostic, phytochemical, and ethnobotanical uses of Bixa orellana. Pharmacognostic studies have focused on the plant's morphological and anatomical features, which aid in its identification and standardization. Phytochemically, Bixa orellana has been reported to contain a range of bioactive compounds such as alkaloids, flavonoids, carotenoids, and essential oils, contributing to its medicinal potential. The ethnobotanical uses of the plant are diverse, with applications in traditional medicine for treating various ailments, including skin conditions, gastrointestinal disorders, and inflammation. This review also explores the scientific validation of these traditional uses and highlights the pharmacological activities associated with the plant's bioactive constituents. Overall, Bixa orellana shows promise as a source of bioactive compounds for pharmaceutical and therapeutic purposes.

Ayurveda is perhaps the oldest medical science of the human civilization which is practised till today in its original form. It is more clearly the science of life as it not only emphasizes on individual health but also taken the health of community as a major concern, the community hygiene, sanitation, good water supply, and drainage system were given great importance right from the age of Indus valley civilization. Many of the public health concepts of today can be understood by the same age old principles and practices of Ayurveda. Public health as a discipline is mainly seen as a part of community medicine. But the classical texts of Ayurveda described public health in a wider dimensions that includes healthy environment, community hygiene, immunization and nutrition. Materials and methods : A systematic review aap scientific literature to compile, critically analyse and draw conclusion on the possible evidence substantiating Public health system of Ancient India. Results: Public health practices, the awareness of hygiene and knowledge of community health was significantly prevalent in ancient India. Many ancient texts of Ayurveda highlighted about infectious diseases and mode of their spread. Discussion: The high level of health status among the prehistoric Indians is a great evidence of the advancement of Community Health approach they had in those days. Many of the travellersvisited India in the ancient days had also recorded the the advanced health practices they witnessed in India.

Introduction: Tonsillitis, an inflammation of the tonsils, is commonly caused by viral or bacterial infections, leading to symptoms such as swelling, pain, difficulty swallowing, and congestion. Traditional remedies offer potential therapeutic benefits, and this study aims to evaluate the efficacy of Tonsenorm, a compound comprising a blend of herbs and minerals, in the management of tonsillitis. Methods: This clinical study was conducted over 90 days with diagnosed cases of tonsillitis. The treatment consisted of Tonsenorm, formulated with Shirisha (Albizia lebbeck), Guduchi (Tinospora cordifolia), Ativisha (Aconitum heterophyllum), Shunthi (Zingiber officinale), Maricha (Piper nigrum), Pippali (Piper longum), Tankan Bhasma, Shuddha Gandhaka and Yashada Bhasma. Objective and subjective parameters, including swelling, pain, burning sensation, congestion, difficult swallowing, and lymph node enlargement, were assessed at 60 and 90 days. Hematological and liver function tests were also performed to evaluate the systemic effects of the treatment. Results: Significant improvements were observed in both subjective and objective parameters. Swelling decreased by 51.41% by day 60, with a further reduction to 52.63% by day 90. Pain relief was 95.80% by day 60, sustained at 92.81% by day 90. Burning sensation, congestion, and difficult swallowing improved by 93.13%, 74.32%, and 82.75%, respectively, by day 90. Lymph node swelling was reduced by 43.58%. Significant improvements were also seen in hematological markers, with a reduction in WBC count and an increase in MCH and MCHC, indicating enhanced erythropoiesis and reduced systemic inflammation. Liver function improved, with a significant decrease in SGOT levels (p = 0.02). Discussion: The observed improvements in symptoms and clinical parameters can be attributed to the anti-inflammatory, analgesic, antimicrobial, and immune-modulatory properties of the herbs and minerals in Tonsenorm. These findings align with traditional Ayurvedic principles and modern pharmacological understanding, supporting the efficacy of the compound in treating tonsillitis. Conclusion: Tonsenorm compound proved to be an effective and holistic therapeutic option for managing tonsillitis, providing significant relief from symptoms while improving immune and inflammatory markers. The compound’s multifaceted actions make it a promising treatment for tonsillitis, offering both short-term and long-term benefits.

Pathya is the right way, Pathya aahara is the proper dietary regime to be followed for a healthy life style. Pathya plays an important role in Upachaya (metabolism) of the body. The need for a well- balanced diet is very important to maintain homeostasis. proper nutrition by suitable dietary regimen accelerates the wound healing process and thus helps in wound healing. wound healing requires active cellular repair mechanism, chemotactic factors and a local environment that supports cell division, movement, and differentiation. Vrana pathya-apathya has been elaborately mentioned by Susrutha in Susrutha Samhita Sutrasthanam. These food acts as a booster for the proper and fast healing of any type of wound. The purpose of this article is to chart a suitable diet chart for wound healing and to discuss the importance of food and selection of the nutrient rich food which enhances the wound healing process.

Ayurveda, the science of life, emphasizes a holistic approach to treatment, considering food, regimen, and medicine as key aspects of healing. This case report presents the Ayurvedic management of a 52-year-old female patient experiencing severe lethargy, abdominal pain, and burning sensation following a viral fever. The treatment was customized based on her Prakriti and Dosha status, demonstrating the effectiveness of personalized Ayurvedic interventions.

Mukhapaka described in Ayurveda, refers to inflammatory condition of the oral cavity, manifesting as ulcer, pain, redness and discomfort. Mukha Rogas is pittaja nanatmaja and rakta pradoshaja vikara and arround 10% of population is suffering with this problem. Mukhapaka occurs due to Nutritional deficiency e.g. Vit.B12 deficiency, Folate deficiency, Stress, Illness, Poor oral hygiene, Eating hot food itmes, Leukaemia, Inflammatory bowel disease, Disturbances in G.I. tract like constipation, Poor hygiene etc. The modern counterpart of Mukhapaka is Recurrent Aphthous Stomatitis, which can arise due to nutritional deficiencies, stress, infections, autoimmune disorders etc. Ayurvedic management focuses on holistic healing through herbal formulations like Haritaki, Triphala, Yashtimadhu along with therapeutic procedures such as Kavala - Gandusha , Pratisarana. In modern medicine, topical analgesics, antiseptic mouthwashes, corticosteroids and nutritional supplements for symptoms relief and healing. This study explores the comaparative aspect of Mukhapaka and its modern medical counterpart.

Praklinna Vartma is defined in Ayurveda as the disease affecting the eyelid characterized by Arujama (painless or mild pain), Bahyata Shunama (swelling on the lid externally), Antaha Klinnata (Stickiness on the lids internally), Srava (Discharge), Kandu (Itching), Nistoda (Pricking sensation) in eyes.1 On reviewing the clinical presentation from modern texts, it is found that Seborrhoeic blepharitis is a sub -acute or chronic inflammation of the lid margins. It is an extremely common disease which is caused when glands of Zeiss secrete abnormal excess neutral lipids which are split by Cornebacterium acne into irritating free fatty acids. It is primarily anterior blepharitis with some spill over posteriorly. It is of common occurrence.

Chronic allergic rhinitis is a common nasal condition characterized by persistent inflammation of the nasal membranes triggered by allergens. Allergic rhinitis, often called hay fever, inflammation, and discomfort, significantly impacts the quality of life. Charak Samhita has mentioned the Allergic Rhinitis as disease called Pratishyay, marked by the main symptoms of sneezing and a watery nose. Ayurvedic literature has emphasized treating Pratishyay by eliminating the causative factors and adopting appropriate lifestyle and medicine otherwise it converts into Dusht Pratishaya. This study aims to explore the Ayurvedic management of chronic rhinitis, with a focus on understanding and treating the five types of Pritishyaya, i.e. Vataja, Pittaja, Kaphaja, Rak taja, Sannipataja. The treatment led to significant improvements in the patient’s symptoms, including reduced nasal congestion and discharge, decreased sneezing, and enhanced overall comfort. The personalized approach proved effective in addressing the specific type of Pritishyaya. The study highlights the efficacy of Ayurvedic treatments in managing chronic rhinitis and emphasizes the importance of individualized care.

Ayurvedic veterinary medicinal tradition of india was existed in the literary record for atleast 4000 yrs and the oral lineage is older than that. First account of a dedicated veterinary hospital comes from time of king Ashoka in 1463bc. Pandava brothers nakula and sahadeva were experts of horse and cattle respectively. Veterinary medicine and Animal husbandry deeply entangled with the cultural history of india. But the advancement of modern science and technology had forced the ancient knowledge in this area to a back track. If this situation persists this is going to be a medical history. Literatures from Hastyāyuṛvedam and opinion from experts reveals that Āyurveda offers simple yet effective solution in veterinary diseases. Ānāham is one such disease. Recent changes in domestication of elephants and their change in diet pattern had accelerated this disease. Due to peculiarities of the digestive system, elephants are more prone to this condition. Intestinal impaction is not an uncommon condition affecting the Asian elephant (Elephas maximus) in captivity.Conventional medicine tries to solve this condition but unfortunately these treatments worsens the condition. Ayurveda can give much more effective solution. This paper throws light upon the unexplored disease ānāham of hastyāyuṛvedam and critical analyze with vataja gulma of Ashtangahridaya. Many more diseases are awaited to be explored.