Isolation And Evaluation Of Trigonella Foenum Graecum Mucilage As Gelling Agent In Diclofenac Potassium Gel
1 Anuradha College of Pharmacy, Anuradha Nagar, Sakegaon Road, Chikhli, Dist- Buldana (M.S.) 443201 India.
Corresponding Author:Mundhe M.R*.
The objective of present work is to find out the gelling potential of mucilage from Trigonella foenum graecum (Fenugreek seeds). Mucilage was isolated from Trigonella foenum graecum by soaking, extraction and boiling with distilled water as solvent and precipitating by addition of acetone as non-solvent and drying at 50-60°C. Mucilage extracted from Fenugreek seeds were subjected to its safety and preformulation studies for its suitability as a gelling agent. Physico-chemical characteristics such as solubility, ash values, swelling index, loss on drying and pH were studied. In the present study five batches of Diclofenac gel were prepared with different concentration of mucilage (viz; 4.0%, 5.0%, 6.5%, 8.0%, 10%w/w), Diclofenac sodium 1%w/w, Glycerin_10%w/v, Methyl paraben 0.02%. The gels prepared with 8.0% of mucilage were found to be ideal and comparable with commercial preparation. The gels were evaluated for drug content, viscosity determination, in-vitro permeation, skin irritation etc. The prepared gels did not produce any dermatological reactions and were well tolerated by the albino mice. The gels were found to be stable with respect to viscosity, drug content and physical appearance at all temperature conditions for 3 weeks. Studies indicate that the extracted mucilage may be a good substitute as a pharmaceutical excipient specifically as a gelling agent.
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How to Cite
M.R*., M., R.R., P., & K.R., B. (2012). Isolation And Evaluation Of Trigonella Foenum Graecum Mucilage As Gelling Agent In Diclofenac Potassium Gel. International Journal of Ayurvedic and Herbal Medicine, 2(2). https://doi.org/10.47191/ijahm/v2i2.12
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