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Quantitative analysis of Copper in arthritic joint effusion and its correlation with Allopathy and Ayurvedic medicinal system.

Published:27 Aug 2012
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Bagla H1*, Karvat A1, Londhe V2, Savrikar S3, Sabnis M4

1 Department of Nuclear and Radiochemistry, Kishinchand Chellaram College, Churchgate- 400020, India.

2 B.Y.L Nair Charitable Hospital & TN Medical College, Dr. A.L. Nair road, Mumbai-400008, India.

3 R.A. Podar Ayurvedic College and Hospital, Worli, Mumbai- 400018, India.

4 Jeevanrekha ayurved chikitsalaya & Research Center, Seawoods, Nerul West, Navi Mumbai - 400 706, India.

Corresponding Author:Bagla H

subjectAbstract

Copper being an essential element in human biology, its relevance in joint effusion has been served to be a non-invasive diagnostic tool for the characterization of joint diseases. The main objective of present work was to establish the correlation between the levels of copper in the synovial fluids (SF) of patients consuming Antiarthritic Ayurvedic drugs (AAD) and Allopathy medicine. Arthrocentesis was adopted to acquire the samples of joint effusion from proved cases of Osteoarthritis (OA), Rheumatoid arthritis (RA) and Bursitis patients. Patient's population was divided into two categories based on the intake of Allopathy and Ayurvedic Drugs. The control comprised of healthy adult volunteers. The concentrations of copper in joint fluid of patients were assessed by Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-AES) analytical technique. It was observed that the patients under the therapy of Antiarthritic Ayurvedic drugs formulation had significantly altering level of mean copper concentration than those under Allopathy drug therapy. Furthermore, the post treatment effects of Antiarthritic Ayurvedic drugs on the amount of copper in joint fluid of patients were fairly analogous to controls. Thus the current study implicates an unequivocal positive alteration of copper in joint fluid of arthritis patients under treatment of traditional medicinal system, thus elucidating its antidote effect for potent joint health. Moreover, it demarcates the two medicinal systems pertaining to its possible elemental variation in joint effusion.

sellKeywords

Synovial fluidOsteoarthritisRheumatoid ArthritisBursitisCopperAntiarthritic Ayurvedic drugs

format_list_numberedReferences

  1. Milanino R, Marrella M, Gasperini R, Pasqualicchio M and Velo G. Cu and Zn body levels in inflammation: an overview of the data obtained from animal and human studies. Agents Actions. 1983; 39:195-209.
  2. Gurgoze MK, Olcucu A, Augun AD, Taskin E and Kilic M, Serum and hair levels of zinc, selenium, iron, and copper in children with iron-deficiency anemia. Biol Trace Elem Res. 2006; 111(1-3): 23-29.
  3. Brown DH, Buchanan WW, El-Ghobarey AF, Smith WF and Teape J. Serum Cu and its relationship to clinical symptoms in rheumatoid arthritis. Ann. Rheum. Dis.1979; 38:174-176.
  4. Milanino R, Rainsford KD and Velo GP. Cu and Zinc in Inflammation. Kluwer, Dordrecht: Kluwer Academic Publishers. 1989.
  5. Milanino R, Conforti A, Franco L, Marrella M and Velo GP. Cu and inflammation--a possible rationa le for the pharmacological manipulation of inflammatory disorders. Agents Actions. 1985; 16: 506-513.
  6. Watts DL. Determining Osteoporotic Tendencies from Tissue Mineral Analysis of Human Hair, Type I and Type II. Townsend Newsletter for Drs. 1986.
  7. Denko CW, Petricevic M and Whitehouse MW. Inflammation in relation to dietary intake of zinc and Cu. IntJ Tiss React. 1981; 3: 73-76.
  8. Philips N, Hwang H, Chauhan S, Leonardi D and Gonzalez S. Stimulation of cell proliferation and expression of matrixmetalloproteinase-1 and interluekin-8 genes in dermal fibroblasts by copper. Connective Tissue Research. 2010; 51(3): 224–229.
  9. Aletaha D. Et al. Rheumatoid Arthritis Classification Criteria, Arthritis & Rheumatism. 2010; 62(9): 2569-2581
  10. WMA Declaration Of Helsinki - Ethical Principles For Medical Research Involving Human Subjects - 18th Wma General Assembly, Helsinki. 1964.
  11. Yazar M, Sarban S, Kocyigit A and Isikan UE. Synovial fluid and plasma selenium, copper, zinc, and iron concentrations in patients with rheumatoid arthritis and osteoarthritis. Biol Trace Elem Res. 2005; 106(2): 123-32.
  12. Krachler M, Domej W and Irgolic KJ. Concentrations of trace elements in osteoarthritic knee-joint effusions. Biol Trace Elem Res. Summer. 2000; 75(1-3): 253-63.
  13. Scudder PR, Mcmurray W, White AG, and Dormandy TL. Synovial Fluid Copper and Related Variables In Rheumatoid And Degenerative Arthritis. Annals of the Rheumatic Diseases. 1978; 37:71-72
  14. Lawrence RC et aL, and Wolfe F. Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum. 1998; 45: 778-799.
  15. National Arthritis Data Workgroup. Arthritis prevalence and activity limitation-United States. MMWR Morb. Mortal Wkly Rep. 1994; 43: 433-438.
  16. Gutteridge JMC. Non-caeruloplasmin copper and the phenanthroline assay Biochem. J. 1984; 218: 983-985.
  17. Soylak M and Kirnap M. Serum Cu and zinc concentrations of patients with Rheumatoid Arthritis Kayseri-Turkey Fresenius Environmental Bulletin. 2001; 10(4): 409–410.
  18. Zoli A, Altomonte L, Caricchio R, et al., Serum zinc and Cu in active rheumatoid arthritis: correlation with interleukin 1 beta and tumor necrosis factor alpha. Clinical Rheumatology.1998; 17(5): 378–382.
  19. Louro MO, Cocho JA, Mera A and Tutor JC, Immunochemical and enzymatic study of ceruloplasmin in rheumatoid arthritis, Journal of Trace Elements in Medicine and Biology.2000;14(3):174–178.
  20. Pelkonen P, Mussalo-Rauhamaa H, Lehto Jand Westermarck T. Serum trace elements in juvenile chronic arthritis. Medicine Clinical Rheumatology.1989; 8(1): 64-70.
  21. Niedermeier W, Creitz EE and Holley HL. Trace metal composition of synovial fluid from patients with rheumatoid arthritis. Arthritis & Rheumatism.1962 ; 439-444.
  22. Samuni A, Chevion M, and Czapski G. Unusual copper induced sensitization of the biological damage due to superoxide radical. J Biol Chem.1981; 256:12632-5.
  23. Beisel WR. The Effect of Infection on Host Nutritional Status. Advances in Human Clinical Nutrition. Vitale, J.J., Broitman, S.A., Eds. John Wright. PSG, Inc., Boston. 1982.
  24. Srivastava KC and Mustafa T. Ginger (Zingiber officinale) in rheumatism and muscubskeletal disorders. Med Hypoth. 1992; 39:342-48.
  25. Deodhar SD, Sethi R and Srimal RC. Preliminary study on antirheumatic activity of curcumin. Indian J Med Res. 1980; 71:632-34.
  26. Halliwell B and Gutteridge JMC. Free radicals in biology and medicine. 2nd ed. Oxford: Clarendon Press. 1989.
  27. Milne L, Nicotera P, Orrenius S and Burkitt MJ. Effects of glutathione and chelating agents on copper-mediated DNA oxidation pro-oxidant and antioxidant properties of glutathione. Arch Biochem Biophys. 1993; 304(1): 102-9.
  28. Amani AR, Somchit MN, Konting MMB and Kok LY. Vitamin E and Curcumin Intervention on Lipid-Peroxidation and Antioxidant Defense System Journal of American Science.2010,6:3.
  29. Baum L and Alex N. Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models. Journal of Alzheimer's disease. 2004; 6: 367–377.
  30. Philips N, Auler S, Hugo R and Gonzalez S. Beneficial Regulation of Matrix Metalloproteinases for Skin Health. Enzyme Research.2011;4.

How to Cite

H, B., A, K., V, L., S, S., & M, S. (2012). Quantitative analysis of Copper in arthritic joint effusion and its correlation with Allopathy and Ayurvedic medicinal system.. International Journal of Ayurvedic and Herbal Medicine, 2(4). https://doi.org/10.31142/ijahm/v2i4.13

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