Volume 9, Issue 3

Virechana is a common panchakarma procedure where purgation is induced by drugs to eliminate morbid pitta dosha to maintain state of health within the body. Among various Virechaka drugs mentioned, Snuhi ksheera is considered best for Tikshna Virechana. But Jayapal is widely used in practice. This study was conducted to compares the effect of Snuhiksheera Bhavit Katuki Churna and Jayapal (Icchabhedi Rasa) in Tikshna Virechana Karma in Krura Koshthi individuals. We compared both drugs on subjective and objective criteria. Among subjective criteria we have taken Samyak Shuddhi Lakshana of Virechana and we have developed some objective criteria to assess Shuddhi through Virechana Karma. In this study total 60 patients were registered and divided into 2 groups. They were administered Snuhiksheera bhavit katuki churna and Icchabhedi Rasa. The result of study was critically analyzed on statistical basis in gaining symptoms of Samyak Shuddhi Lakshana i.e. Strotovishuddhi, Laghuta, Urja Agni, Praptishchavita Pitta Kaphanilanam, ManashchaTushti. And other Lakshana i.e. Vaigiki, weight, initiation of Vega, time between Vega, associated complaints, defecation on next day. After applying proper statistical tools following result were obtained. The overall effect of therapy in Group A showed that maximum number of volunteers (53.4%) had PravarShuddhi with discomfort, while 46.6% volunteers had PravarShuddhi without discomfort. The overall effect of therapy in Group B showed that maximum number of volunteers (76.6%) had PravarShuddhi without discomfort, while 23.4% volunteers had PravarShuddhi with discomfort; none patient had Madhyam Shuddhi without discomfort or Heena Shuddhi in both groups.

Pain is multidimensional, hence, there is very advanced researches on it in science nowadays, but pain still remains the major cause of disability affecting the large number of population in the world. An integrated approach towards Pain Management should possibly answer the grief involved in treating this Symptom of varying degrees. Beginning with, in this article, along with the classical text with special references to pain, and its management through ayurvedic procedures (Snehan, Swedan, Agnikarma, Jalaukaavcharan, Vedhankarma, Lepankarma&Bastikarma) we have also focused on some other aspects to eliminate the chronic pain, such as removing toxins, proper nutrition, creating strong digestion, stress management etc. Further, concentrating on the physical body, Yoga eventually influences all aspects of the person: vital, mental, emotional, intellectual and spiritual. The asanas and pranayama harmonize the physiological system and initiate a ‘relaxation response’ in the neuroendocrinal system. Also we have thrown a light on, the role of Madhur-Amla- Lavan Rasa Aushadhiin Pain management due to DhatukshayjanyaVataprakopain view of G-PCR bio-signaling of taste and Pain modulation is incorporated to explain role of palliative medicines.

Centella asiatica (gotukola) has been used as a medicine in the Ayurvedic tradition of India for thousands of years. It is listed in the historic Susruta samhita, an ancient Indian medicinal text. In China, gotukola is one of the reported “Miracle elixirs of life”. In 19th century, Gotukola and its extracts were incorporated into the Indian pharmacopeia and considered as the Food for the brain. This study evaluated the anticonvulsant effect of chloroform extract of Centella asiatica (CA) with particular reference to carbohydrate metabolism in different types of rat muscles. The rats were randomly divided into 4 groups having 6 in each group: i.e. Control group received Saline, PTZ-induced epileptic group (60 mg/kg b.w op/ 1 day), Epileptic group pretreated with chloroform extract (CE), and Epileptic group pretreated with Diazepam (DP; Reference control) (2 mg/kg b.w/ip/ day). The CA extract is administered at the dose of 200 mg/kg body weight orally for one week. The experimental results were observed that the decreased content of Total carbohydrates in the muscles i.e. White Vastus (WV), Red Vastus (RV), Soleus (Sol) and Gastrocnemius (GN); increased the glycogen and glucose levels during PTZ-induced epilepsy in all the muscles. The reversal changes were observed on pre treatment with the chloroform extract and diazepam. Hence, it is evident that the different bioactive factors of Centella offered protection against PTZ-induced epilepsy.

Due to lack of systematized scientific research methodology, even though with references available in classics, there is need of logical, critical study of principles and concepts with the help of modern methodology. The purpose of Snehapana is to bring Dosha from Shakha to Koshtha, this effect can be achieved by Matranusara, Arohana, Sadyo and Pravicharana types of Snehana. If Dosha is in ChalaShakhagataAvastha or is already present in Koshtha then AlpaSnehana can also bring the same action. So SadyoSnehana can be more beneficial here. Many references regarding Sadyo Snehana Yogas are mentioned in classics but their dosage and method of administration is not clearly mentioned. Two classical Yogas having good palatability, easy preparation were chosen. Aims & Objectives: To fix the dose & method of administration of Sadyo Snehana. To observe Samyak Snigdha Lakshana of Ksheera Yavagu in Group A& Shuddha Go-Ghritha + Saindhava Lavana in Group B. To compare the effect of Sadyo Snehapana in both groups.Total 60 Shodhananga Snehana Yogya healthy volunteers or diseased were randomly selected for the study by taking consent. ShodhanangaSnehapanaVidhi was followed. The Samyak Snigdha Lakshanas were observed and tabulated. The Results obtained were interpreted – Both the Yogas gave Significant results at p<0.01 in attaining SamyakSnigdhaLakshanas,i.e. Overall: Out of 60 volunteers maximum of 45% volunteers had UttamaYoga, 40% volunteers had MadhyamaYogaLakshanas of SamyakSnehana followed by 15% of AyogaLakshanas.

Healthy Skin is the reflection of Healthy Body wherein the affliction of former will not only have an impact on Somatic make-up but also on Psychological and Social aspects of an individual. Pama (Scabies) is one among the Kshudra Kushthas with Kapha Pitta5 predominant disorder explained under Kushtha. Though Herbal and Rasoushadhis individually have their own importance in Ayurveda, but multitude effects of drugs are under consideration now a day and hence a combination of herbo-mineral drugs became more popular and so a compound preparation Kushthadalanarasa as internal medicine and Gandhakadi Yoga for external application was chosen in group A and compared with the effect of external application Gandhakadi Yoga in group B. In present clinical study of 40 patients of Pama, result showed statistically significant with p<0.01 in both groups. In Group A there was significant relief in symptoms like Kandu, Thoda, Daha, Pidika, Srava i.e. 30% completely relief, 35 % moderately improved and 25 % mildly improved compared to Group B with 30 % moderately improved and 50 % were mildly improved in symptoms Thoda and Srava.

Azadiracta indica (Neem) native of India has uncountable medicinal properties of variousbioactive compounds which are present in the roots to seeds of this plant.Biologically active compounds namely Azadirachtin, meliacin, , Meliantriol ,Nimbin, Nimbidin, Salannin, Salannol vilasinin,are isolated from different parts of Neem plant .Biologically more active compound is azadirachtin, a tetranotriterpenoid is isolated from the seeds of Neem which is actually a mixture of seven isomeric compounds named as azadirachtin A-G and azadirachtin E is the most effective one. Two bioactive compounds azadirachtin M and azadirachtin N collected from seed kernels of Azadirachta indica,these two compounds hasa major role in medicinal activities.The bioactive compound “Azadiachtin” has antimalarial, antigingivitis and antiplaque properties and also has antibacterial action by destroying the bacterial cells.The bioactive compound Nimbidin has anti- inflammatory antipyretic , antiarthritic , hypoglycemic , anti- gastric ulcer, antibacterial and antifungalproperties.Nimbin exhibits spermicidal function. The neem oil was extracted from neem kernels. This oil used in soap industry and by pharmaceutical industries and contain many active ingredients which are called triterpene or limonoids .Neem oil showed good antiseptic properties. It is applied in the treatment of skin complaints as furuncles and eczema.Therapeutical potentials of neem is due to the presence of various Bioactive compounds in roots to seeds of its body.

Triterpenoid saponins isolated and characterized from various sources are reviewed. The recent techniques used in their isolation and structure elucidation are discussed. A compilation of the triterpenoid saponins isolated during the period 2013-2016 along with their occurrence, available physical data and spectroscopy used for their characterization is included. The biological activities and corrosion inhibition of the triterpenoid saponins are also discussed. References 1. Garai, S. Advances in Triterpenoid Saponins Research 2007-2012. J.Herbal Medicine 2016; 2(3): 1-23. 2. Colorado J, Munoz D, Marquez D, Elena Marquez M, Lopez J. Thomas OP, Martinez A et al. Ulososides and Urabosides-Triterpenoid Saponins from the Caribbean Marine Sponge Ectyoplasia ferox. Molecules 2013; 18: 2598-2610, doi 10.3390/molecules 18032598. 3. Hamed AI, Masullo M, Pecia L, Gallotta D, Mahalel VA, Pawelec S, Stochmal A, Piacente S et al. 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Phytochemicals such as alkaloids, flavonoids, pigments, phenolics, terpenoids, steroids and essential oils are a large group of plant-derived compounds commonly found in diets high in fruits, vegetables, beans and cereals. The sample of Maha Vallathy Leghiyam (MVL) was analyzed for their phytochemical compositions, vitamins and minerals constituents. Based on the observed results explored the presence of bioactive constituents comprising flavonoids, phenols. These substances are the main reason for beneficial role against human health related problems, and it is responsible for the anti-inflammatory, antioxidant, antimicrobial, antitumor and anticancer properties. During the present study, we have tested the Antioxidant activity of through DPPH scavenging assay. The phytochemical screening revealed the extract richness in Tannins, Phlobatannin, Saponins, Flavonoids, Steroids and Alkaloids. Antioxidant activity was determined by DPPH radical scavenging assay, in which IC50 values obtained by DPPH activity for MVL aqueous crude extract was found to be 50μg/mL. The obtained results suggest that MVL has promising antioxidant activity and could serve as potential source of natural antioxidants.