Volume 8, Issue 1

The present study was aimed to evaluate the anti-hyperglycemic activity and in vivo anti-oxidant effect of ethyl acetate extract of Actinopteris dichotoma.It is commonly known as peacock’s tail which belongs to the family Pteridaceae. Ethyl acetate extract of whole plant of Actinopteris dichotoma (EAAD) was prepared by Soxhlet extraction. Wistar rats weighing (180-200 gms) were divided into 6 groups (n=6), and three doses (100 mg/kg, 200 mg/kg and 400 mg/kg) of extract were selected. Insulin was used as a standard drug. Diabetes was induced by alloxan (120mg/kg, i.p) in control group. The animals were pre-treated with the extracts at specified doses for a period of 14 days.On 21stday, the blood glucose levels along with anti-oxidant enzymes like Superoxide dismutase (SOD), Catalase (CAT) and lipid peroxidase (LPO) were also determined in all animals. Histopathological studies were also performed to observe the effect of test drug on pancreas.The EEAD at 200 mg/kg body weight showed a significant reduction in blood glucose levels (p<0.001) with the value of 150.6 mg/dl on 21st day as compared to the diabetic control. Also, the extract showed significant improvement in SOD and CAT with 35.61 and 40.56 U/mg of protein. Histopatho study of pancreatic tissue exhibited normal exocrine structure with less hemorrhage or damage in endocrine portion.These results suggest that ethyl acetate extracts of Actiniopteris dichotoma Bedd at the dose of 200 mg/kg showed anti-hyperglycemic effect with a substantial evidence of increased pancreatic cell viability as compared to the diabetic control.

UTI is very comman disease caused by E.coli, gram negative bacteria already present in intestine, Kidney and urinary tract. Alkaline condition favours the multiplication of bacteria. Presence of E.coli creats burning micturition, eargency of urine with trouble. Use of antibiotics and intake of excessive amount of water can cure it but leads some side effects. various research reveal that colourful berries especially ‘Cranberry’ is highly efficient to cure Eicole infection. As it contains numerous natural products as ‘Antioxidants’, which boost our immune system along with anticlinging property thus prevents bacterial adhesion on the wall of urinary tract as well as urinary bladder.

Medicinal plants are being used widely, either as single drug or in combination in health care delivery system Hemidesmus indicus R.Br, also popularly known as ‘Anantmul’in Marathi ‘Sariva’ in Sanskrit and ‘Indian sarsaparilla’ in english is a semi erect shrub belonging to family Asclepiadaceae. It is widely distributed throughout India.It contains various phytoconstituents belonging to the category glycosides, flavonoids, tannins, sterols and volatile oils. It is traditionally used in skin disorders, dysentery, diarhhoea, syphilis, dyspepsia, leucoderma burning sensation, chronic fever and asthma,leprosy, loss of appetite, eye diseases, epileptic disorder, dyspepsia, nutritional disorder,leucoderma ,ulcer and rheumatism and used for diuretic and blood purifier purpose. Pharmacological studies carried out with its extract and purified compounds indicate that this plant possess antioxidant, hepatoprotective, anti-ulcer, antimicrobial, anticancer, hypoglycemic, antithrombotic, antihyperlipidemic, otoprotective, analgesic, anti-inflammatory and immunomodulatory activities. It also protects radiation-induced DNA damage. This review provides comprehensive and unique information regarding ayurvedic and modern aspect of sariva under one umbrella which will be helpful to researchers and pharmaceutical industries to expand the pharma worth of this wonder drug.

Obesity is a burning issue before medical science. It is a penalty of today’s life style. If we follow daily and seasonal routine as advocated by Ayurveda, we can prevent as well as overcome various life style induced problems.Though the problem comes, we have an answer it by Ayurved management. Obesity leads to many serious issues such as hypertension, hyperlipidemia, ischemic heart diseases, diabetis, renal dysfunctions, infertility and even brain disorders. In various ayurved texts, obesity is described as medovruddhi as a separate entity and cause & complication of other diseases.In the management of medovruddhi, many acharyas have mentioned various formulations among which we selected Haridryadi gana for the study which was found to be very significant. REFERENCES 1. Shashtri A. Part –I, Sushrut Samhita of Sushruta Chaukhambha Prakashan Varanasi:, P No. 78,81,82. 2. Upadhyay Y. Part – II, Madhav Nidan, Chaukhambha Prakashan Varanasi:, Reprint 2010,34 P. 36 3. Shashtri A. Part – I, Sushrut Sutrosthan Chaukhambha Sanskrit Sansthan Varanasi: Reprint 2013, 4/12-13 P.39 4. Tripathi B. P-I, Charak Sharirsthan, Chaukhambha Surbharti Varanasi: Reprint 2014, 7/15 P. 927 5. Upadyay Y. P-II, Madhav Nidana, Chaukhambha Prakashan Varanasi: Reprint 2010, 34/1 P. 36 6. Upadyay Y. P-II, Madhav Nidana, Chaukhambha Prakashan Varanasi: Reprint 2010 34/34 P. 36 7. Desai R. R, Ayurvediya Kriya Sharir, 8th Ed., Shri Baidnath Nagpur: 1999 P.646 8. Tripathi B. P – I Charak Samhita Chaukhambha Surbharti Varanasi Reprint 2014, 22/9 P. 412 9. Shashtri A. P-I, Sushrut Sutrasthan, Chaukhambha Sanskrit Sansthan Varanasi: Reprint 2013 15/7 P. 75 10. Shashtri A. P- I, Sushrut Sutrasthan, Chaukhambha Sanskrit Sansthan Varanasi:, Reprint 2013 15/13 P. 76 11. Gupta K. A. Ashtanga Hridaya, Chaukhambha Prakashan Varanasi: Reprint 2007 11/18 P.116 12. Tripathi B. P – I Charak Samhita, Chaukhambha Surbharti Varanasi: Reprint 2014, 8/106 P. 764 13. Tripathi B. P-I, Charak Samhita, Chaukhambha Surbharti Varanasi: Reprint 2014, 5/14 P. 697 14. Shashtri A. P- I Sushrut Sutrasthan, Chaukhambha Surbharti Varanasi:, Reprint 2013 9/11 P. 97 15. Shashtri A. P- I Sushrut Sutra Chaukhambha Surbharti Varanasi:, Reprint 2013 4/30 P. 42 16. Tripathi B. P-I Chaukhambha Surbharti Varanasi:, Reprint 2014, 7/10 P. 924 17. Tripathi B. P-I Charak Samhita Chaukhambha Surbharti Varanasi:, Reprint 2014 27/32 P. 390 18. Tripathi B. P-II Charak Samhita, Chaukhambha Surbharti Varanasi:, Reprint 2014 5/136 P. 269 19. Shashtri A. P-I, Sushrut Sutra Chaukhambha Surbharti Varanasi:, Reprint 2013 35/32 P. 173 20. Tripathi B. P-II, Charak Samhita Chaukhambha Surbharti Varanasi: Reprint 2014 15/15 P. 553 21. Tripathi B. P-II, Charak Samhita Chaukhambha Surbharti Varanasi:, Reprint 2014 15/13 P. 552 22. Tripathi B. P-I, Charak Samhita, Chaukhambha Surbharti Varanasi:, Reprint 2014 5/15 P. 699 23. Shashtri A. P-I, Sushrut Sutrasthan Chaukhambha Surbharti Varanasi:, Reprint 2013 15/37 P. 81 24. Upadhyay Y. Madhav Nidanam, Chaukhambha Prakashan Varanasi:, Reprint 2010 34/1 P. 34 25. Tripathi B. P-I, Charak Samhita Chaukhambha Surbharti Varanasi:, Reprint 2014 21 P. 300 26. Shashtri A. P-I, Sushrut Sutra, Chaukhambha Surbharti Varanasi:, Reprint 2013 15/37 P. 81 27. Misra B. S. 2nd Ed., Bhav Prakash, Chaukhambha Sanskrit Series Varanasi: P. 424 28. Sampurn Pandit, Shri. Misra, Bhav Prakash P. 424 29. Shashtri A. P-I, Sushrut Sutra, Chaukhambha Surbharti Varanasi:, Reprint 2013 21/36 P. 121 30. Shashtri A. P-I, Sushrut Sutra, Chaukhambha Surbharti Varanasi:, Reprint 2013 15/37 P. 81 31. Upadhyay Y. P- II Madhav Nidanam, Chaukhambha Prakashan Varanasi: Reprint 2010 34/8 P. 35 32. Tripathi B. P-I, Charak Samhita, Chaukhambha Surbharti Varanasi:, Reprint 2014 21/20 P. 404 33. Shashtri A. P-I, Sushrut Sutra Chaukhambha Surbharti Varanasi:, Reprint 2013 15/38 P. 82 34. Shashtri A. Bhaishajya Ratnavali, Choukhamba Sanskrit Sansthan Varanasi: 2005 P. No. 62. 35. Shetty M., 1st Ed. Yog Ratnakar, Choukhamba Sanskrit Series Varanasi: 2005 P. No. 97, 98. 36. Dan L. Longo Harrison’s Principles of Internal Medicine N Shah 18th Edition 2008 37. Shaha S. N., 8th Ed, API Vol 1-2, The Association Principal of India 2012 P. No. 985 38. Jay Pee Brothers Medical Publishers Ltd. Textbook of pathology 6th Edition 2010. 39. Charchill Living Stone London Principles and Practice of Medicine Davidson 21th Edition P. 116. 40. Sharma P.V., Dravyaguna Vigyan, Choukhamba Bharti Varanasi:, 2006 P.162. 41. Vaidya Bapalal, Nighantu Adarsha, Choukhamba Bharti Varanasi: 2005, P No. 559, 49, 435, 847. 42. .Kirtikar K.R., 2nd Ed. Indian Medicinal Plants, International Distributer Dehradoon: 2006 P No. 102, 569, 727, 749. 43. Sharma P. Dravyaguna Vigyan Choukhamba, Prakashan P. 537 44. Sharma P. Dravyaguna Vidyan P. 822 45. Deshpande A. P. Dravyaguna Vigyan, Proficient Publishing House Pune: 2016 P. No. 563, 519, 809, 852,977. 46. Sharma P.V. Dravyagun Vigyan, Choukhamba Bharti Varanasi: P. No. 253, 463 47. Chunekar K. Chaukhambha Bharti Varanasi, Bhawprakash Nighantu, Reprint 2013 1/197 P. 111, 113, 118,247 48. Satoskar R. S. Popular Prakashan Pvt. Ltd Mumbai Pharmacology & Pharmacoth erapeutics 21th Edition Reprint 2009P 2010 P. 575 49. Mahajan B. K. Jaypee Brothers Medical Publishers Pvt. Ltd. Methods in Biotatatistics 7st Edition 2010.P.117.

India is a country with a rich and varied cultural heritage where Hindu Dharma is held in high esteem. Hindu dharma is not a religion but a way of life, which has been refined over millennia to help individuals lead successful lives. The unique relationship between Samskara (sacraments) and culture shapes one’s lifetime by defining moments or goals that nourish, purify and grant dignity and decorum. The goal of samskara is to improve the culture as a whole. The samskaras are performed for the physical, social and religious development of the individual. Ancient Hindu mythology described sixteen Samskara for a person. This article will described in detail eight samskara for growth and development of children, along with their medical relevance: Jatakarma (birth rituals), Namkaran (naming the child), Nishakraman (first outing), Annaprashan (first feeding), Chudakarna (head shaving), Karnachedan (piercing the earlobes), Upanayana (thread ceremony) and Vedarambha (start of formal education).

Eyes are the most important organs in Urdhawajatrugata Sthana. We must protect and take loving care of these delicate organs. Urdhawajatrugata vyadis includes the diseases of eye, ear, nose and throat. Among all of them only eye is only organ whose anatomy, diseases and their treatment are detailed described in Uttar Tantra of Sushruta Samhita. Kriyakalpa is main therapeutic process for netra roga which is described in chapter 18 in Uttar Tantra of Sushruta Samhita. Tremendous advancement made in ophthalmic medicine in recent years has begun a new era in the history of ophthalmology. Different types of Kriyakalpa, their indications and probable mode of action will be discussed in present review article.

The study was designed to evaluate the ethosomal gel of leaf extract of Mangifera indica, its incorporation in to gel formulations. The prepared gels were assessed for their anti-inflammatory activity against carrageenan induced oedema. Different formulations of ethosomes using lecithin, cholesterol and ethanol were prepared using different doses of Mangifera indica herbal leaf extracts. Carbopol 940 was used to prepare ethosomal gel. The entrapment efficiency of ethosomes was 65.1%-96.54% and the average vesicle size was 920nm. Three formulations (different doses) were selected based on entrapment efficiency and drug release. Prepared gels were then evaluated for physicochemical characteristics and drug content. In vivo anti-inflammatory activity studies were carried out using carrageenan-induced rat paw oedema model. Male Wistar rats weighing about 150-180 gms were divided into 5 groups of six rats (n=6) each. Diclofenac sodium was used as a standard drug (MaKami pharmacy). Three gel formulations (100, 200 and 300 mg) were used as test drugs. The pH of the gel formulations was found to be in the range of 5.4-6.2 and viscosities were between 2250- 2399 centipoises. The drug content of gels ranged between 74.67-82.31%. Among the prepared formulations of Mangifera indica FN2 (Formulation 2, 200 mg) was found to possess significant percentage inhibition (54%) when compared to control at 4 hrs. From the study, it can be concluded that ethosomal gel served as an efficient drug delivery system for herbal extract with potential anti-inflammatory property.

Guillain-Barre syndrome (GBS) is an acute, rapidly evolving areflexic motor paralysis with or without sensory disturbance. It occurs year around at a rate of between 1 and 4 cases per 100,000 annually. Increasing data indicate that it is an autoimmune disease, often triggered by a preceding viral or bacterial infection with organisms such as Campylobacter jejuni, Helicobacter pylori, or Mycoplasma pneumoniae. Vaccination against the flu, rabies, and meningitis are also documented precipitating factors that have been reported. Investigations include Electromyography, CSF studies and serum CK levels. To date, treatment for GBS has been aimed primarily at immunomodulation (IVIG). Mamsa-Medogata Vata is the condition that can be categorized under GBS due to proximity of their clinical presentation. REFERENCES 1. Longo DL, Fauci AS, Kasper DL, Jameson JL, Hauser SL, Loscalzo J. Vol. 2. New York, NY: McGraw Hill; 2010. Harrison's Principle of Internal Medicine; p. 3473. 2. Harve B Sarnat, Vol. 2, 2008, Nelson textbook of pediatrics, 18 th edition; p 2565 3. Lee JH, Sung IY, Rew IS. Clinical presentation and prognosis of childhood Guillain-Barré syndrome. J Paediatr Child Health. 2008 Jul-Aug. 44(7-8):449-54. [Medline]. 4. Tripathi R. Charak Samhita of Charaka, Chikitsasthan, Vatvyadhi Chikitsa. Varanasi: Chaukhamba Sanskrit Series; 2009. p. 693. 5. Souayah N, Nasar A, Suri MF, Qureshi AI. Guillain-Barré syndrome after vaccination in United States: data from the Centers for Disease Control and Prevention/Food and Drug Administration Vaccine Adverse Event Reporting System (1990-2005). J Clin Neuromuscul Dis. 2009 Sep. 11(1):1-6. 6. Tripathi R. Charak Samhita of Charaka, Chikitsasthan, Vatvyadhi Chikitsa. Varanasi: Chaukhamba Sanskrit Series; 2009. p. 701. 7. Tripathi R. Charak Samhita of Charaka, Chikitsasthan, Vatvyadhi Chikitsa. Varanasi: Chaukhamba Sanskrit Series; 2009. p. 693. 8. Mishra SN. Bhaishajya Ratnavali of Govindadas Sen, Jwaraadhikar. Varanasi: Chaukhamba Sanskrit Series; 2007. p. 218.. 9. Amlapitta Chikitsa Shlok 1-5. Varanasi: Chaukhamba Sanskrit Series; 2010. Bhisagratna and Brahmasankar Sastri Yogratnakar; p. 244. 10. Shastri A. Chapter 4, Verse 16. Varanasi: Dalhan Commentary Chaukhamba Sanskrit Series; 2007. Sushrut Samhita of Sushruta Sharir Sthan, Garbhavyakaran; p. 59. 11. Singh SS, Pandey SC, Srivastav S. Chemical and medicinal properties of tinospora cordifolia. Indian J Pharmacol. 2003;35:83–91. 12. Krishna KL, Bhatt J, Patel J. Guduchi (Tinospora cordifolia): Biological and medicinal properties, a review. Internet J Altern Med. 2009;6:10–5. 13. Mishra SN. Bhaishajya Ratnavali of Govindadas Sen Vatvyadhirogaadhikar. Varanasi: Chaukhamba Sanskrit series; 2007. p. 530. 14. Joshi YG. Charak Samhita of Charaka, Vimansthan Rogbhishakjitiyaviman. Chapter 8, Verse 97-98. Pune: Vaidya Mitra Publications; 2003. p. 599. 15. Longo DL, Fauci AS, Kasper DL, Jameson JL, Hauser SL, Loscalzo J. Entitled “GBS”. Part 17, Chapter 385. II. New York, NY: McGraw Hill; Harrison's Principle of Internal Medicine; p. 3477.

The word srotas is derived from “sru”gataudhatu which means movement.Srotas are channels which transport anna, dhatus, tridoshas and pranas. When the flow of appropriate nutrients through srotas is proper and unobstructed, there is health. When there is blockage, excess or deficiency in these channels, disease occurs. Herbs act in various ways. Some stop attipravitti while others removesang. In this article an effort has been made to analyze the action of dravyas in different pathologies exclusively at srotas level in order to highlight their medico clinical importance in our body.

Objectives: To assess the efficacy of Aabresham (Bombyx mori) for the prevention of atherosclerosis. Methods: Randomized single blind standard control risk factor trial was conducted in National Institute of Unani Medicine Hospital, Bangalore from March 2015 to March 2016. Fifty patients with risks of atherosclerosis were selected and randomly assigned into two groups 30 in test group and 20 in control group. Test group was treated with the decoction of Aabresham (Bombyx mori), six grams in the morning empty stomach for two months and control group was treated with Atorvastatin, ten mg, in the evening for the same duration. The response was evaluated by the assessing the subjective and objective parameters. The result was analyzed statistically by using Fisher Exact test, Chi-Square test and Student‘t’ test (Unpaired & Paired). Results: Test group showed significant reduction in breathlessness, palpitation, headache, blood pressure, serum cholesterol, Low density lipoprotein (LDL) & MDA (Malonedialdehyde) concentration (p<0.01) but chest pain, serum triglyceride, haematocrit and HDL(High density lipoprotein) values were found statistically insignificant in both groups. Overall, improvement was observed in test group except blood urea. Conclusion: Aabresham(Bombyx mori shown to have an astounding potential in the prevention of atherosclerosis. It’s anti-oxidant, anti inflammatory, platelet stabilizing and anti- arrhythmic effect plays an unparallel role in the inhibition of development & progression of atherosclerosis. Integration with regimental therapies and dietary modification will potentiate its efficacy.

Type 1 diabetes mellitus is the most common Pediatric chronic endocrine illness. The prevalence of juvenile diabetes is 1% - 4% of the total diabetic population with the highest incidence during puberty (10-15 years age group). Hypothesis :- Psychological stress has been hypothesized to be an environmental factor appears to play an significant role in the pathogenesis of childhood onset type 1 diabetes mellitus. Objective :- To study the main psychosocial factors associated with the development of type 1 diabetes based on the review of the scientific literature Methodology :- Research underscore the following risk factors , stressful life events, personal and interpersonal factors and also protection factors. Applied Implications of Ayurveda Principles in stress management, Behavioral intervention and positive parenting intervention and help them cope with their illness. Results :- Parenting stress and negative stress events were associated with the induction of diabetes-related autoimmunity in early childhood. Conclusion :- Psychological stress inducing increased cortisol levels leading to insulin resistance and beta-cell stress, could be involved in the development of Type 1 diabetes.